Abstract:
:The effectiveness of different compounds in the generation of acrylamide (AA) from asparagine, was determined by reacting asparagine with mono-, di- and polysaccharides, as well as four different oxo-compounds known to be involved in carbohydrate metabolism/degradation. Quantitation of AA formed either under aqueous conditions or in low water model systems revealed glucose and 2-oxopropionic acid as the most effective compounds in AA generation, when reacted in model systems with a low water content (about 1 mol-% yield). Interestingly, heating of asparagine in the presence of 2-oxopropionic acid generated quite high amounts of 3-aminopropionamide (3-APA), which itself effectively generated AA upon heating in aqueous solution, as well as in low water systems. Because this is the first report on amounts of 3-APA generated by Maillard-type reactions, the general role of 3-APA as key intermediate in AA formation is discussed in detail. In addition, first results on the development and application of an HPLC/fluorescence method for AA quantitation are presented.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Schieberle P,Köhler P,Granvog Mdoi
10.1007/0-387-24980-x_16subject
Has Abstractpub_date
2005-01-01 00:00:00pages
205-22eissn
0065-2598issn
2214-8019journal_volume
561pub_type
杂志文章abstract::Apoptosis is a highly regulated process where key players such as BCL-2 family members control the recruitment of the mitochondrial subroutine. This culminates in the release of cytochrome c from the organelle in the cytoplasm, where it is required for the activation of effector caspases. The complete release of cytoc...
journal_title:Advances in experimental medicine and biology
pub_type: 历史文章,杂志文章,评审
doi:10.1007/978-1-4419-6706-0_6
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abstract::Histamine is one ofthe most versatile biogenic amines with multiple roles during the immune response and in allergic disorders. With four distinct G protein-coupled receptors (H1R, HER, H3R and H4R), intracellular histamine binding sites (most likely members of the cytochrome P450 family) as well as a membrane transpo...
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journal_title:Advances in experimental medicine and biology
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abstract::Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Volume 1 international leading experts will present up-to-date overviews about t...
journal_title:Advances in experimental medicine and biology
pub_type:
doi:10.1007/978-94-007-0763-4_1
更新日期:2011-01-01 00:00:00
abstract::All previous studies on the yeast metabolome have yielded a plethora of information on the components, function and organisation of low molecular mass and macromolecular components involved in the cellular metabolic network. Here we emphasise that an understanding of the global dynamics of the metabolome in vivo requi...
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pub_type: 杂志文章
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pub_type: 杂志文章
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abstract::Xeno-transplantation of pancreatic islets represents a promising therapeutic alternative for the treatment of type 1 diabetes mellitus. However, potent innate immune responses induced shortly after the transplantation of donor islets to the recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR), exer...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::The process of natural selection favours germ-line gene segments that encode CDRs that have the ability to recognize a range of structurally related antigens. This presents an immunological advantage to the host, as it can confer protection against a common pathogen and still cope with new or changing antigens. Cross-...
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 临床试验,杂志文章
doi:10.1007/978-1-4615-2488-5_13
更新日期:1993-01-01 00:00:00
abstract::Although many studies have described the role of periostin in various diseases, the functions of periostin derived from alternative splicing and proteinase cleavage at its C-terminus remain unknown. Further experiments investigating the periostin structures that are relevant to diseases are essential for an in-depth u...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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abstract::Many aspects of the structure of chymosin are quite unique even though structure comparisons indicate a high degree of structural homology with other eukaryotic aspartic proteinases. The structural homology is shown to be directly related to the sequence homology which varies from 30 to 60%. The recent structures of p...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-6012-4_3
更新日期:1991-01-01 00:00:00
abstract::Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this dis...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::Studies in this laboratory on the nuclear binding sites (acceptors) for progesterone receptor in the developed chick oviduct have resulted in the detection of seasonal variations in the levels and functions of the receptor. Cytosol preparations obtained from the chick oviducts during the winter/spring period between J...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
abstract::Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer (NK) cells. These ligand/receptor interactions govern T cell and NK cell development a...
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pub_type: 杂志文章,评审
doi:10.1007/978-981-13-9367-9_2
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract::Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available to measure it in clinical routine care. The aim of this work is...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00