Some properties of monoamine oxidase and a semicarbazide sensitive amine oxidase capable of the deamination of 5-hydroxytryptamine from porcine dental pulp.

abstract：:Hemin is a potential cytolytic agent. To test the effect of vitamin E on hemin-mediated permeability in cell membranes, sheep erythrocytes were chosen as an appropriate model to study hemolysis induced by hemin. Hemin-induced hemolysis but did not elicit lipid peroxidation in sheep erythrocytes. Vitamin E was effectiv...

journal_title：Biochemical pharmacology

authors： Wang F,Wang T,Lai J,Li M,Zou C

更新日期：2006-03-14 00:00:00

abstract：:Necroptosis is a form of programmed, caspase-independent cell death that is involved in various pathologic disorders such as ischemia/reperfusion injury, acute kidney injury and inflammatory bowel diseases. Identification of necroptosis inhibitors has great therapeutic potential for the treatment of necroptosis-associ...

journal_title：Biochemical pharmacology

authors： Qin X,Hu L,Shi SN,Chen X,Zhuang C,Zhang W,Jitkaew S,Pang X,Yu J,Tan YX,Wang HY,Cai Z

更新日期：2020-07-01 00:00:00

abstract：:Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Considering the structural similarity between gabexate mesylate and argi...

journal_title：Biochemical pharmacology

authors： Erba F,Fiorucci L,Pascarella S,Menegatti E,Ascenzi P,Ascoli F

更新日期：2001-02-01 00:00:00

abstract：:The enzyme steroid 5 alpha-reductase (EC 1.3.99.5) catalyzes the NADPH-dependent reduction of the double bond of a variety of 3-oxo-Delta(4) steroids including the conversion of testosterone to 5 alpha-dihydrotestosterone. In humans, 5 alpha-reductase activity is critical for certain aspects of male sexual differentia...

journal_title：Biochemical pharmacology

authors： Hiipakka RA,Zhang HZ,Dai W,Dai Q,Liao S

更新日期：2002-03-15 00:00:00

abstract：:SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide) is a novel benzotriazine di-N-oxide which shows unusually high selective toxicity towards hypoxic cells, probably as a result of reductive bioactivation. Using an HPLC assay for the parent drug and its 2- and 4-electron reduction products (SR 4317 and SR 4330, respecti...

journal_title：Biochemical pharmacology

authors： Walton MI,Workman P

更新日期：1990-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by some virus-encoded proteins, possibly acting at multiple levels of control, which are also known to be involved in the regulation of gene expression in uninfected cells (transcriptional, post-transcriptional, nucleocytoplasmic transport, and t...

journal_title：Biochemical pharmacology

authors： Schröder HC,Sarin PS,Rottmann M,Wenger R,Maidhof A,Renneisen K,Müller WE

更新日期：1988-10-15 00:00:00

abstract：:To study the effect of sex hormones and alcohol on the hepatic activities of alcohol metabolizing enzymes, estradiol or testosterone were administered for 4 weeks to ovarectomized or sham operated adult female rats pair-fed nutritionally adequate liquid diets containing either alcohol (36% of total calories) or isocal...

journal_title：Biochemical pharmacology

authors： Teschke R,Wannagat FJ,Löwendorf F,Strohmeyer G

更新日期：1986-02-01 00:00:00

abstract：:The enhanced nitric oxide (NO) and prostaglandin (PG) generation of activated macrophages is controlled by glucocorticoid-sensitive inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. Negative feedback regulation of iNOS expression by the products of both pathways has been suggested, but...

journal_title：Biochemical pharmacology

authors： Pang L,Hoult JR

更新日期：1997-02-21 00:00:00

abstract：:Minoxidil sulphotransferase (MST) activity was determined in the cytosolic fraction of rat skin and liver. MST of rat skin is similar to the P (phenol)-form of phenosulphotransferase (PST) of human tissues with respect to thermostability and inhibition by 2,6-dichloro-4-nitrophenol (DCNP). p-Nitrophenol, a prototype s...

journal_title：Biochemical pharmacology

authors： Wong KO,Tan AY,Lim BG,Wong KP

更新日期：1993-03-09 00:00:00

abstract：:The characteristics of the muscarinic receptor in isolated gastric fundic cells from rabbit were determined by radioligand binding techniques and functional tests. The dissociation constants (KDS) of selective (hexahydrosiladifenidol and pirenzepine) and non-selective (N-methylscopolamine and atropine) muscarinic rece...

journal_title：Biochemical pharmacology

authors： Baudiere B,Monferini E,Giraldo E,Ladinsky H,Bali JP

更新日期：1987-09-15 00:00:00

abstract：:The antithyroid drug propylthiouracil (PTU) has been shown previously to reduce hepatic oxygen utilization and to protect the liver from ethanol-induced injury. The present study examined the effect of PTU on hepatic microsomal oxygen consumption and on the activities of NADPH-cytochrome P450 reductase (CYP-reductase)...

journal_title：Biochemical pharmacology

authors： Ross AD,Varghese G,Oporto B,Carmichael FJ,Israel Y

更新日期：1995-03-30 00:00:00

abstract：:Treatment of red blood cells with the copper (II) ascorbate system causes increased lipid peroxidation, increased membrane microviscosity, and phospholipid translocation with a concurrent decrease in cytosolic catalase and glutathione peroxidase activities. All these changes are prevented if the cells are treated with...

journal_title：Biochemical pharmacology

authors： Chattopadhyay A,Choudhury TD,Bandyopadhyay D,Datta AG

更新日期：2000-02-15 00:00:00

abstract：:In assessing the biological effects of exposure to a complex chemical mixture, it is important to determine how the behavior of one compound may be influenced by the presence of other compounds in the mixture. In this study the effect of pre-exposure to an organic extract of diesel exhaust or to selected compounds in ...

journal_title：Biochemical pharmacology

authors： Howard AJ,Mitchell CE,Dutcher JS,Henderson TR,McClellan RO

更新日期：1986-07-01 00:00:00

abstract：:We studied the effect of DW2282-,[(S)-(+)-4-phenyl-1-[N-(4-aminobenzoyl)-indoline-5-sulfonyl-4,5-dihydro-2-imidazolone].hydrochloride], a newly developed anti-cancer agent, on cell proliferation, cell cycle progression, and induction of apoptosis in human promyelocytic leukemia (HL-60) cells. DW2282, a diarylsulfonylu...

journal_title：Biochemical pharmacology

authors： Piao W,Yoo J,Lee DK,Hwang HJ,Kim JH

更新日期：2001-12-01 00:00:00

abstract：:The inhibitory effects of N-(4-hydroxyphenyl)retinamide (HPR) and its glucuronide derivative on the growth of MCF-7 human breast cancer cells in vitro were compared. The results indicate that the glucuronide had slightly greater potency and much less cytotoxicity than the free retinoid. At a concentration of 10(-6) M,...

journal_title：Biochemical pharmacology

authors： Bhatnagar R,Abou-Issa H,Curley RW Jr,Koolemans-Beynen A,Moeschberger ML,Webb TE

更新日期：1991-05-15 00:00:00

abstract：:Daily subcutaneous administration of the oral hypoglycaemic agent, diphenyleneiodonium at a low dose (1.5 mg/kg body weight) over a 4-5 week period resulted in a normoglycaemic stable animal model of impaired oxidative phosphorylation in the rat. Diphenyleneiodonium specifically inhibits NAD-linked mitochondrial oxida...

journal_title：Biochemical pharmacology

authors： Cooper JM,Petty RK,Hayes DJ,Morgan-Hughes JA,Clark JB

更新日期：1988-02-15 00:00:00

abstract：:Opiates act through a specific receptor to inhibit the striatal adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4,6.1.1] and stimulate a high-affinity GTPase (EC 3.6.1). The present study analyzes the functions of the striatal adenylate cyclase complex following chronic morphine treatment in the rat. The in...

journal_title：Biochemical pharmacology

authors： Tirone F,Viganó A,Groppetti A,Parenti M

更新日期：1988-03-15 00:00:00

abstract：:A series of N-hydroxy-N'-aminoguanidine derivatives was studied for their effects on L1210 cell growth and ribonucleotide reductase activity. With the twelve compounds studied, there was a good correlation between the inhibition of L1210 cell growth and the inhibition of ribonucleotide reductase activity. The most pot...

journal_title：Biochemical pharmacology

authors： Cory JG,Carter GL,Bacon PE,T'ang A,Lien EJ

更新日期：1985-08-01 00:00:00

abstract：:The levels and subcellular distribution of enzymes involved in defenses against reactive oxygen superoxide dismutase (SOD; E.C.1.15.1.1), glutathione peroxidase (GPX; E.C.1.11.1.9), catalase (CAT; E.C.1.11.1.6), and DT-diaphorase (DT; E.C.1.6.99.2) and of the conjugating enzymes glutathione transferase (GST; E.C.2.5.1...

journal_title：Biochemical pharmacology

authors： Eliasson M,Boström M,DePierre JW

更新日期：1999-10-15 00:00:00

abstract：:Reduction of exogenous lipoic acid to dihydrolipoate is known to occur in several mammalian cells and tissues. Dihydrolipoate is a potent radical scavenger, and may provide significant antioxidant protection. Because lipoic acid appears in the bloodstream after oral administration, we have examined the reduction of ex...

journal_title：Biochemical pharmacology

authors： Constantinescu A,Pick U,Handelman GJ,Haramaki N,Han D,Podda M,Tritschler HJ,Packer L

更新日期：1995-07-17 00:00:00

abstract：:We have shown previously that bis(N,N-dimethylhydroxamido)hydroxooxovanadate (DMHV) is an excellent reversible inhibitor of protein tyrosine phosphatase (PTP) in vitro. DMHV does not carry a charge under physiological pH conditions and is anticipated to permeate cell membranes more easily than vanadate. In the present...

journal_title：Biochemical pharmacology

authors： Cuncic C,Desmarais S,Detich N,Tracey AS,Gresser MJ,Ramachandran C

更新日期：1999-12-15 00:00:00

abstract：:The effect of 5 consecutive daily i.p. doses of CPZ (5 mg/kg), PZ (10 mg/kg) and PMZ (10 mg/kg) on the activity of kynurenine hydrolase and kynurenine aminotransferase in mouse liver was studied. All three phenothiazines effected an increase in the activity of kynurenine hydrolase per unit weight of liver with CPZ sho...

journal_title：Biochemical pharmacology

authors： Mostafa MH,El-Sewedy SM,El-Bassiouni EA,Abdel-Tawab GA

更新日期：1982-07-01 00:00:00

abstract：:Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular energetics and which on the other is a ubiquitous signaling molecule when released into the extracellular media. Extracellular ATP accumulates in inflammatory environments where it acts as a damage-associated molecular pattern...

journal_title：Biochemical pharmacology

authors： Pelegrin P

更新日期：2020-12-20 00:00:00

abstract：:Human CYP2E1 is one of the pharmacologically and toxicologically important cytochrome P450 isoforms. Earlier studies have reported that the CYP2E1 expression is extensively regulated by post-transcriptional and post-translational mechanisms, but the molecular basis remains unclear. In the present study, we examined th...

journal_title：Biochemical pharmacology

authors： Mohri T,Nakajima M,Fukami T,Takamiya M,Aoki Y,Yokoi T

更新日期：2010-04-01 00:00:00

abstract：:5-Fluorouracil (FUra) has been administered to mice bearing xenografts of human colon adenocarcinomas. In two tumor lines, HxGC3 and HxVRC5, intrinsically resistant to FUra, 2'-deoxyuridylate (dUMP) accumulated 13.4- and 23.9-fold above basal levels. In HxELC2 xenografts, which demonstrated some sensitivity to FUra, t...

journal_title：Biochemical pharmacology

authors： Houghton JA,Weiss KD,Williams LG,Torrance PM,Houghton PJ

更新日期：1986-04-15 00:00:00

abstract：:Three sulfolipid compounds, 1, 2, and 3, have been isolated from a higher plant, a pteridophyte, Athyrium niponicum, as potent inhibitors of the activities of calf DNA polymerase alpha and rat DNA polymerase beta. The inhibition by the sulfolipids was concentration dependent, and almost complete inhibition of DNA poly...

journal_title：Biochemical pharmacology

authors： Mizushina Y,Watanabe I,Ohta K,Takemura M,Sahara H,Takahashi N,Gasa S,Sugawara F,Matsukage A,Yoshida S,Sakaguchi K

更新日期：1998-02-15 00:00:00

abstract：:Characteristics of erythromycin binding to Staphylococcus aureus were determined by using kinetics and equilibrium binding experiments. Both methods yielded identical values of the dissociation constant, i.e. 0.1 muM. This value was in accord with that found with a bacterial extract of ribosomes which are the organell...

journal_title：Biochemical pharmacology

authors： Barre J,Fournet MP,Zini R,Deforges L,Duval J,Tillement JP

更新日期：1986-03-15 00:00:00

abstract：:Certain anticonvulsant drugs require N-acetylation as a major route of metabolic clearance. Single point mutations of the polymorphic N-acetyltransferase gene (pNAT) are the primary cause for impaired drug acetylation. Pharmacokinetic parameters are altered in slow acetylator phenotypes and this may compromise drug sa...

journal_title：Biochemical pharmacology

authors： Borlak JT,Harsany V,Schneble H,Haegele KD

更新日期：1994-11-01 00:00:00

abstract：:Various agents stimulate the secretion of lung surfactant from alveolar type II cells by increasing intracellular Ca2+, cyclic adenosine-3':5'-monophosphate (cAMP), or diacylglycerol. A few agents, including the purified surfactant protein A, are known to inhibit the secretion by an unknown mechanism. In the present s...

journal_title：Biochemical pharmacology

authors： Chander A,Sen N

更新日期：1993-05-05 00:00:00

abstract：:Quinone reductase 2 has been discovered in 1961 and rediscovered in 1997. Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Ten years later, evidences begin to point to a versatile role of this enzyme. Indeed, QR2 is strongly suspected to be the molecular target of ...

journal_title：Biochemical pharmacology

authors： Vella F,Ferry G,Delagrange P,Boutin JA

更新日期：2005-12-19 00:00:00