Abstract:
BACKGROUND:The prognostic significance of the leukocyte subsets in peripheral blood has not yet been investigated in hepatocellular carcinoma patients. We sought to clarify the prognostic value of preoperative peripheral blood leukocyte subset counts, especially the absolute monocyte count, in HCC patients who have undergone hepatic resection. METHODS:We retrospectively examined the relation between the preoperative absolute number of peripheral monocytes and clinicopathologic factors or long-term prognosis in 198 patients with hepatocellular carcinoma who underwent curative resection. RESULTS:Univariate analysis indicated a significantly worse 5-year disease-free survival rate in patients with a peripheral blood monocyte count > 300/mm(3) (14.8%) than in patients with a count < or = 300/mm(3) (29.2%). There were no significant differences between patients in disease-free survival based on the lymphocyte or neutrophil count. According to multivariate analysis, preoperative peripheral blood monocyte count > 300/mm(3), alpha-fetoprotein level > 100 ng/mL, aspartate aminotransferase level > 100 IU/mL, and presence of microvascular invasion were independent risk factors for disease-free survival of less than 5 years. The peripheral blood monocyte count was higher in patients of male sex or those with a noncirrhotic liver, microvascular invasion, major hepatic resection, older age (>65 years), large tumor (> or =50 mm), or increased platelet count (>100,000/mm(3)) than in patients without these characteristics. CONCLUSIONS:Our findings indicate that the preoperative absolute count (>300/mm(3)) of peripheral blood monocytes may be related to tumor progression and that it is an independent risk factor for recurrence of hepatocellular carcinoma after resection. Postoperative adjuvant chemotherapy might be necessary in patients with elevation of the preoperative absolute count of peripheral blood monocytes.
journal_name
Surgeryjournal_title
Surgeryauthors
Sasaki A,Iwashita Y,Shibata K,Matsumoto T,Ohta M,Kitano Sdoi
10.1016/j.surg.2005.10.009subject
Has Abstractpub_date
2006-06-01 00:00:00pages
755-64issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(05)00678-1journal_volume
139pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Operative injury to the body from all procedures causes a stereotypical cascade of neuroendocrine, cytokine, myeloid, and acute phase responses. This response has been examined commonly by the use of cortisol, interleukin-6 (IL-6), white cell count, and C-reactive protein (CRP). We aimed to determine which m...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:10.1016/j.surg.2014.09.009
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Ex situ liver surgery allows liver resection and vascular reconstruction in patients who have liver tumors located at critical sites. Only a small series of studies about ex situ liver surgery is available in the literature. No long-term results have been published. METHODS:Twenty-four patients were conside...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.105500
更新日期:2000-05-01 00:00:00
abstract::Eighty-four patients with recurrent kidney stones, serum calcium levels in the upper normal quartile, and most of whom with hypercalciuria had their parathyroids surgically explored. Parathyroid adenomata were found in 19 patients, hyperplasia in 39, and normal parathyroids in 26. Postoperatively there was a significa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::Nine patients (median age, 81 years) with primary hyperparathyroidism were treated with intravenous infusions of disodium pamidronate (APD), which is a bisphosphonate drug. Six patients had severe hypercalcemia (serum calcium concentration, greater than 3 mmol/L) persisting after rehydration with saline and treatment ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Hemorrhage-induced activation of endothelial cell Na+/H+ -exchanger results in cellular swelling, which physically impedes capillary filling and compromises gut perfusion. We hypothesized that correction of the vascular volume deficit by conventional resuscitation does not improve capillary filling unless ce...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.08.007
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Long-term outcomes after face transplantation are rarely reported in the scientific literature. Here we present outcome data of a partial face allograft recipient 10 years after transplantation. METHODS:Medical records were reviewed for functional and psychosocial outcomes as well as complications. Histopat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.01.010
更新日期:2020-06-01 00:00:00
abstract::This report describes an experimental study in which dogs with prosthetic graft replacement of the infrarenal abdominal aorta were challenged at progressive time intervals following graft placement with a single intravenous infusion of Staphylococcus aureus in order to determine the duration of susceptibility to graft...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Mortality after acute respiratory distress syndrome is higher in males than in females. Gender differences in pulmonary vascular reactivity and local inflammatory response may explain this disparity. We hypothesized that endothelium-dependent pulmonary vasorelaxation is impaired in males and that this effect...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.03.002
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-18 is a proinflammatory cytokine involved in the regulation of cell-mediated and innate immune responses to infection, trauma, and inflammation. Elevated levels of IL-18 have been noted to correlate with organ dysfunction after injury. This study evaluates the relationship between IL-18 prom...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2003.248
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipe...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.05.013
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Follicular thyroid cancer is a heterogeneous disease including follicular and Hürthle cell and tumors with and without vascular and major capsular invasion. Analyses of prognosis and risk groups have been criticized for not taking these differences into account. METHODS:Retrospective analysis was done of 24...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::An evaluation of the in situ bacteriologic status of a total parenteral nutrition (TPN) catheter, when the patient is pyretic but the cause of infection is not obvious, permits continued use of the catheter if the result is negative, as opposed to removal of the suspected catheter. To find a predictive value for the i...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Transplant renal artery stenosis occurred in 12 of 101 consecutive kidney transplants. Stenoses were all located in the renal artery distal to the anastomosis. Two separate forms of stenosis are recognized: angulation and segmental. All transplant patients with severe diastolic hypertension, refractory to medical mana...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Propranolol has been shown previously to restore bone marrow function and improve anemia after lung contusion/hemorrhagic shock. We hypothesized that daily clonidine administration would inhibit central sympathetic outflow and restore bone marrow function in our rodent model of lung contusion/hemorrhagic sho...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.08.043
更新日期:2017-03-01 00:00:00
abstract::To assess the role of portal hemodynamics in the development of postshunt encephalopathy, we studied 19 patients after small-diameter portacaval H grafting (SD-PCHG). We used contrast studies as well as technetium-labeled macroaggregated albumin injected into the portal vein to assess direction of portal flow. We then...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Seeding of vascular grafts with genetically engineered human endothelial cells (hECs) secreting antithrombogenic or fibrinolytic agents has considerable clinical potential. METHODS:An adenoviral vector was used to transfer the human tissue-type plasminogen activator (htPA) gene to hECs, and the ability of t...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90269-5
更新日期:1997-07-01 00:00:00
abstract::Major intra-abdominal operations result in profound immunodepression. In addition, manipulation of malignant tumors may release tumor cells into the systemic and portal circulations. The additive effects of immunodepression and tumor cell release may enhance the metastatic potential of tumors. Perioperative correction...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS:Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Orga...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.04.039
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Ventral abdominal wall hernias are common lesions and may be associated with life-threatening complications. The application of laparoscopic principles to the treatment of ventral hernias has reduced recurrence rates from a range of 25% to 52% to a range of 3.4% to 9%. In this study, we review our experience...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00283-6
更新日期:2003-10-01 00:00:00
abstract::A case report of a girl with anomalous venous drainage of a lower extremity who had a successful venous transplant is presented, along with a review of some factors thought to be important in venous grafting. In our patient there are several factors that may have contributed to long-term patency. As demonstrated by ve...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether nitric oxide regulates insulin secretion in the isolated perfused human pancreas. METHODS:Single-pass perfusion was performed in four pancreata with a modified Krebs medium. Sequential 10-minute infusions (separated by 10-minute basal periods) of (1) 25 nmo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80305-9
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Donor characteristics and graft quality were recently reported to play an important role in the recurrence of hepatocellular carcinoma after liver transplantation. Our aim was to establish a prognostic model by using both donor and recipient variables. METHODS:Data of 1,010 adult patients (training/validati...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.01.022
更新日期:2018-04-27 00:00:00
abstract::A patient who underwent jejunoileal bypass for morbid obesity developed servere renal failure associated with hyperoxaluria and renal oxalosis. Renal function improved and oxalate excretion decreased following hemodialysis and restoration of gastrointestinal continuity. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:The American College of Surgeons National Surgical Quality Improvement Program is well recognized in surgical quality measurement and is used widely in research. Recent calls to make it a platform for national public reporting and pay-for-performance initiatives highlight the importance of understanding whic...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.04.034
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:We have previously shown that in a randomized comparison of laparoscopic (LC) versus small incision (SC) cholecystectomy, postoperative hospital stay is comparable. This randomized prospective study compares the postoperative pain, analgesic and antiemetic consumption, perceived health, and metabolic and res...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1067/msy.1998.87552
更新日期:1998-05-01 00:00:00
abstract::The esophageal mucosa is exposed to damaging agents both by ingestion and reflux. Using our in vivo rabbit model of esophagitis, we have observed that acute luminal exposure (within 1 to 5 minutes) to potentially harmful agents, such as acid, bile, or ethanol, induces a rapid increase in mucosal blood flow; whereas pr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Pancreatic polypeptide (PP) deficiency has been associated with impaired hepatic sensitivity to insulin and pancreatogenic diabetes in chronic pancreatitis. Since pancreatic resection might also result in PP deficiency, hepatic responses to insulin infusion (0.25 mU/kg/min) were determined by the euglycemic glucose cl...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) promotes tumor angioinvasion while VEGF-C is a potent lymphangiogenic factor. This study aims at evaluating serum VEGF (sVEGF) and sVEGF-C levels in recurrent papillary thyroid carcinoma (PTC) patients. METHODS:Serum samples were collected preoperatively from 85 pat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.07.027
更新日期:2008-12-01 00:00:00
abstract:INTRODUCTION:Posthepatectomy liver failure (PHLF) is a severe complication after hepatectomy for colorectal liver metastases. This study evaluated its actual incidence and its effects on short- and long-term overall survival (OS) in a specialized center. MATERIALS AND METHODS:Between 2006 and 2008, 193 patients who un...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.05.039
更新日期:2014-01-01 00:00:00