Abstract：
:The esophageal mucosa is exposed to damaging agents both by ingestion and reflux. Using our in vivo rabbit model of esophagitis, we have observed that acute luminal exposure (within 1 to 5 minutes) to potentially harmful agents, such as acid, bile, or ethanol, induces a rapid increase in mucosal blood flow; whereas prolonged exposure (10 to 60 minutes) results in mucosal injury and ablation of blood flow. We have also shown that capsaicin-sensitive mucosal afferent nerves can modulate esophageal blood flow. These findings led us to hypothesize that the reactive increase in blood flow induced by luminal agents represents a mechanism of protection mediated by capsaicin-sensitive nerves. The objective of these experiments was to determine if luminal capsaicin, a specific probe for visceral afferent nerves, could both preserve mucosal blood flow and protect against ethanol injury. Rabbits were subjected to luminal instillation of 50% ethanol with or without 1% capsaicin. Blood flow was measured with microspheres at baseline and after 2 and 10 minutes. Rabbits exposed only to ethanol developed severe mucosal injury coincident with near ablation of mucosal blood flow. In contrast, rabbits exposed to ethanol with capsaicin showed protection of the epithelium with a sixfold increase in mucosal blood flow. We conclude that capsaicin-sensitive nerves in the esophagus are local effectors of mucosal protection by virtue of preserving blood flow.
journal_name
Surgeryjournal_title
Surgeryauthors
Bass BL,Trad KS,Harmon JW,Hakki FZsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
419-25; discussion 425-6issue
2eissn
0039-6060issn
1532-7361journal_volume
110pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. METHODS:The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms b...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.07.030
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Increased epithelial permeability may contribute to septic complications after alcohol intoxication. Prior ethanol (EtOH) exposure leads to structural and functional effects on cytoskeletal components important in maintaining barrier integrity. The cytoskeleton is also important in the transcellular transpor...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.127553
更新日期：2002-10-01 00:00:00
abstract：:Nelson's syndrome--progressive cutaneous hyperpigmentation with x-ray film evidence of an expanding pituitary tumor--is now a well-recognized sequela of bilateral adrenalectomy for Cushing's disease. It is estimated to occur in 8% to 38% of adults. Because Cushing's disease is rare in children, a higher incidence of N...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Obstruction of the superior vena cava (SVC) secondary to malignant or benign diseases is rarely treated by surgical reconstruction. The purpose of this retrospective study is to report our experience and compare our results with previous data in the literature. METHODS:From 1993 to 2006, 24 patients underwe...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.08.003
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Conventional parathyroidectomy involves a bilateral neck exploration with the patient under general anesthesia with a thorough search for all parathyroid tissue. The purpose of this study was to assess the efficacy and safety of unilateral neck exploration under local anesthesia in patients with asymptomatic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2099.101834
更新日期：1999-12-01 00:00:00
abstract：:Coexistent caval and portal hypertension was recognized on preoperative angiographic study of a patient with cirrhosis and variceal bleeding. This hemodynamic situation can preclude adequate reduction of portal hypertension by portasystemic shunt and can result in fatal postoperative bleeding. Resection of a very larg...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:This investigation documented the effect of protamine sulfate pretreatment on the adverse hemodynamic and hematologic sequela of rapid intravenous protamine administration in heparinized dogs having undergone prior implantation of aortic prostheses. Fourteen dogs underwent infrarenal aortic replacement with 6 mm inner...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:Laparoscopic techniques are being used increasingly in the repair of ventral hernias and offer the potential benefits of a shorter hospital stay, decreased wound complications, and possibly a lower recurrence rate. Despite good results from high-volume centers, significant complications may occur with this a...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.06.054
更新日期：2005-10-01 00:00:00
abstract：:Myocardial high-energy phosphate and glucose-6-phosphate levels were determined in the in vivo pig heart model during ischemic arrest and reperfusion to determine the effectiveness of potassium cardioplegia in myocardial protection. Thirty-five pigs were divided into six experimental groups consisting of 2-hour normot...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:Refractory esophageal variceal hemorrhage (EVH) remains a formidable problem in patients awaiting liver transplantations. Transjugular intrahepatic portosystemic shunts (TIPS) have provided an alternative approach for managing EVH that may obviate the need for portosystemic shunt surgery. Experience with TIPS placemen...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Analysis of the case histories of 17 patients who developed subglottic obstruction following cricothyroidotomy shows that all 10 patients with chronic stenosis had acute laryngeal pathology at the time of initial operation. Seven patients were identified as having acute subglottic obstruction with granulation tissue. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:One hundred five students in our surgical clerkship were evaluated independently by two faculty members, a chief resident, a written multiple-choice examination, and two oral examinations. Faculty and chief resident evaluations included a written explanation and a score from 1 (honors) to 5 (failing). Oral and written...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:A pathologic complete response (pCR) can be observed in up to 25% of patients after preoperative chemoradiotherapy for rectal cancer and is associated with an improved long-term prognosis. However, few data are available regarding the effect of pCR on postoperative morbidity. This study aimed to assess the i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:To clarify the physiopathologic mechanism leading to a marked increase in aromatic amino acids (AAA) in acute hepatic failure (AHF), we compared two experimental models of AHF. Ten pigs were submitted to one-stage hepatic devascularization (group A); in eight other pigs total hepatectomy was performed (group B). The a...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor-D (VEGF-D), the activating ligand for vascular endothelial growth factor receptor-3 (VEGFR-3), has been identified as an important endogenic tumor-associated lymphangiogenic factors which can promote lymphatic metastasis from primary tumor. Lymphatic metastasis, which is th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.04.025
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is a rare disease in which recurrence after surgery is common. Mitotane is the primary systemic treatment for recurrent ACC; data are limited regarding the impact of mitotane on recurrent ACC. METHODS:We reviewed the records of all patients who underwent surgery for ACC eval...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.09.006
更新日期：2007-12-01 00:00:00
abstract：:Pure follicular carcinoma of the thyroid gland has become a relatively uncommon type of primary thyroid neoplasm in the United States. During a 20-year period (1962 to 1982) 37 cases of pure follicular carcinoma were treated at the University of Michigan Medical Center. Cases of the follicular variant of papillary car...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:We sought to determine the long-term effects of ABO-compatible donors (ACD) in adult cardiac transplantation (OHT). METHODS:The United Network for Organ Sharing database was examined for adult OHT from 2000 to 2010. RESULTS:Of 20,353 patients undergoing OHT, 3,046 (15%) were with ACD. Recipients of ACD wer...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.04.023
更新日期：2013-08-01 00:00:00
abstract：:In 112 patients with severe ischemia of the lower limb and without a suitable saphenous vein, 99 femoropopliteal and 22 femorodistal bypass procedures were performed with the modified human umbilical vein (Biograft, Meadox Medicals Inc., Oakland, N.J.). Seventy-eight percent of the operations were performed for limb s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND:Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remai...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The incidence of adenocarcinoma of the esophagogastric junction is rapidly increasing, and the extent of lymphadenectomy for such tumors remains controversial. The aim of this study was to identify the pattern of dissemination by examination of all lymph nodes retrieved from resected tumors of the esophagoga...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.110024
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:The development of effective gene transfer in utero will provide alternative approaches to the treatment of genetic disorders. For many disorders, the fetal liver and peritoneum are important target tissues. Our goals were to compare the tissue sites and duration of transferred gene expression after intraper...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:Autonomously functioning thyroid nodules (AFTNs) in children and adolescents (under age 18) are unusual but are not as rare as earlier reports suggested. These lesions have a significantly different biologic potential than similar lesions in older patients. In the younger age group there is a more rapid progression to...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:This study evaluated the mixed leukocyte culture (MLC) technique to quantitate differences in kidney allograft survival between unrelated animals. Each of five beagles received two heterotopic kidney allografts, one from a mongrel dog showing high MLC stimulation and one from a second mongrel dog showing a low MLC sti...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
abstract：BACKGROUND:Operative therapy for Crohn's disease (CD) recurrence is supposed to be more complex and demanding than primary resection. The purpose of this study was to assess a postoperative course after reoperation for the recurrence of CD. METHODS:From 1998 to 2008, 61 patients underwent reoperation for the recurrenc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.02.001
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Telomerase reverse transcriptase promoter mutations were recently found to be associated with poorer prognosis in patients with papillary thyroid carcinoma. Correlation between telomerase reverse transcriptase messenger RNA expression and survival of patients with papillary thyroid carcinoma has not been det...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.04.054
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Adrenal venous sampling (AVS) is used in the workup of primary hyperaldosteronism (PA). The purpose of this study was to determine the success rate of AVS and to examine the decision-making process after "less than ideal" AVS. METHODS:A total of 60 patients underwent 62 AVS for PA. Biochemical evidence of a...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.07.026
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:The number of dendritic cells (DC) in the local tumor environment correlates with patient survival in numerous tumors. The relationship of DC infiltration in the tumor microenvironment and prognosis was examined in patients with pancreatic adenocarcinoma. METHODS:Forty-seven pancreatectomy specimens with a ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.119937
更新日期：2002-02-01 00:00:00
abstract：:Thyroglossal cysts are common developmental abnormalities of the thyroid gland. The malignant form of these cysts, however, is extremely rare, with fewer than 100 cases reported since 1915. Here we add 10 cases of malignant thyroglossal cysts, nine women and one man, encountered at M.D. Anderson Cancer Center, based o...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:For the past 14 years, we have been performing laparoscopic adrenalectomy via the lateral transabdominal as well as the posterior retroperitoneal approach. The aim of this study is to describe patient selection criteria for each approach with comparison of perioperative outcomes. METHODS:In patients with sm...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.06.057
更新日期：2009-10-01 00:00:00
