Abstract:
BACKGROUND:Increased epithelial permeability may contribute to septic complications after alcohol intoxication. Prior ethanol (EtOH) exposure leads to structural and functional effects on cytoskeletal components important in maintaining barrier integrity. The cytoskeleton is also important in the transcellular transport of proteins including the polymeric immunoglobulin receptor (pIgR) mediated transport of immunoglobulin A (IgA) to the luminal surface of mucosal tissues. We (1) investigated the effects of acute EtOH exposure on cell monolayer barrier integrity and IgA transport and (2) assessed the importance of microtubule function on these functions in vitro. METHODS:Confluent Madin-Darby canine kidney (MDCK) epithelial cells transfected with pIgR cDNA were exposed to 1% or 5% EtOH, and transcytosis of dimeric IgA was measured. Paclitaxel was used to pretreat a subset of MDCK cells. Results. EtOH exposure resulted in a concentration and time dependent decrease in IgA transcytosis. This was associated with physical derangements in the integrity of the cell monolayer. Pretreatment with paclitaxel completely abrogated these effects. CONCLUSIONS:EtOH causes both physical and immune derangement of epithelial cell barrier function. Decreased secretory IgA at mucosal surfaces may initiate septic complications after EtOH intoxication.
journal_name
Surgeryjournal_title
Surgeryauthors
Diebel LN,Liberati DM,Dulchavsky SA,Diglio CA,Brown WJdoi
10.1067/msy.2002.127553subject
Has Abstractpub_date
2002-10-01 00:00:00pages
573-81; discussion 581issue
4eissn
0039-6060issn
1532-7361pii
S0039606002001356journal_volume
132pub_type
杂志文章相关文献
SURGERY文献大全abstract:PURPOSE:The purpose of this study was to evaluate whether ultrasonography is helpful in predicting malignancy in patients with a thyroid nodule and atypia/follicular lesion of undetermined significance (AFLUS). METHODS:All patients with a preoperative ultrasound who underwent thyroidectomy for a nodule with AFLUS comp...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.06.043
更新日期:2014-10-01 00:00:00
abstract::Cowden's disease (multiple hamartoma syndrome) is a syndrome involving abnormalities of multiple organ systems. Transmitted in an autosomal dominant pattern, it carries a high frequency of mammary carcinoma in early middle age in affected women. The hyperkeratotic cutaneous and gingival markers of the disease are its ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::A patient who underwent jejunoileal bypass for morbid obesity developed servere renal failure associated with hyperoxaluria and renal oxalosis. Renal function improved and oxalate excretion decreased following hemodialysis and restoration of gastrointestinal continuity. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Hepatopancreatobiliary surgery has a high incidence of postoperative morbidity, including incisional surgical site infection. Although several studies showed that subcuticular sutures reduced incisional surgical site infection in other fields of surgery, their impact on hepatopancreatobiliary surgery remains...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.04.002
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:High-dose perioperative corticosteroids are the standard of care for steroid-treated patients undergoing surgery. There is little evidence, however, to support this practice. We investigated the safety of perioperative low-dose steroids in patients with inflammatory bowel disease (IBD) undergoing major color...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.02.019
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that gadolinium ethoxybenzyl diethylenetriamine penta acetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging may be used to evaluate liver function. The aim of this study was to assess whether the signal intensity of Gd-EOB-DTPA magnetic resonance imaging may be used to predic...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.04.041
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Mucosal melanoma of the female genitalia is a rare neoplasm. Only nine reports reviewing more than 40 patients have been published on this subject in the past 30 years. These lesions arise from melanocytes, which can be found within the mucosa lining the female genital tract. Surgical resection is the mainst...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Four-dimensional computed tomography (4D-CT) provides both functional and highly detailed anatomic information about parathyroid tumors. The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyr...
journal_title:Surgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.surg.2006.07.028
更新日期:2006-12-01 00:00:00
abstract::Patients with stages O and I malignant melanomas of the trunk and proximal limbs, having had wide excisions only without lymph node dissections, were reviewed to determine whether the presence or absence of muscle fasciae correlated with prognosis. Prior to 1969 most patients seen at The University of Texas M. D. Ande...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1982-10-01 00:00:00
abstract::Experimental data suggesting that oxygen-derived free radicals may play a role in the myocardial injury associated with ischemia and reperfusion are presented. In several studies of prolonged global myocardial ischemia, the administration of free radical scavenging agents, such as superoxide dismutase, catalase, and m...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1983-09-01 00:00:00
abstract::Sixty patients with recurrent ulcers after vagotomy were treated by partial gastrectomy without revagotomy. One patient died after surgery. Seven others died of unrelated causes and one patient was lost to follow-up before 5 years, without rerecurrence having been diagnosed. Of the remaining 51 patients, one underwent...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Plasma from laparotomized mice has been shown to stimulate in vitro tumor growth when compared to results with preoperative plasma. This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth. METHODS:Eighty-four patients un...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.125308
更新日期:2002-08-01 00:00:00
abstract::A 26-year-old woman developed a desmoid tumor of the lower abdominal wall shortly after the birth of her fourth child. It measured 15 by 17 cm. and involved most of the lower abdominal wall of this small-framed woman. Operative removal would have been mutilating and almost surely doomed to failure. No treatment was gi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Previous studies using simulation-based curricula have focused largely on technical skills. We developed a set of simulation-based modules that focus on intraoperative decision making. The objective of this study was to conduct a faculty evaluation of: (1) the usefulness of 4 newly developed, simulation-base...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.10.010
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The benefit of adding external beam radiation to adjuvant chemotherapy in patients that have undergone a margin positive resection for early stage, pancreatic ductal adenocarcinoma has not been determined definitively. METHODS:The National Cancer Data Base was queried to evaluate the utility of adjuvant rad...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.09.022
更新日期:2018-05-01 00:00:00
abstract::A conical silicone rubber balloon was placed in the left hemithorax of fetal lambs and progressively inflated through an exteriorized catheter over the last trimester. Newborn lambs died of severe respiratory insufficiency, despite maximal resuscitation. The lungs were markedly hypoplastic with greatly reduced parench...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::One hundred five students in our surgical clerkship were evaluated independently by two faculty members, a chief resident, a written multiple-choice examination, and two oral examinations. Faculty and chief resident evaluations included a written explanation and a score from 1 (honors) to 5 (failing). Oral and written...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is among the most common malignant neoplasms worldwide. Only few data on HCC in noncirrhotic livers without viral hepatitis in Western countries are available. The purpose of this study was to define the outcomes and potential prognostic factors associated with survival after h...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.09.015
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The increasing success of renal transplantation is paralleled by the increased size of the waiting list. Efforts to increase the donor pool have included the use of living-unrelated kidney donors (LURDs). METHODS:During a 12-year period our center performed 309 transplantation from living donors; 279 patien...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80264-9
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Resection for hepatocellular carcinoma in patients with cirrhosis and impaired liver function is usually unjustified because of higher surgical risks and poorer long-term prognosis. METHODS:A retrospective comparison of the background and resectional results of patients with cirrhosis and hepatocellular car...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80238-8
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:This study was performed to assess the relationship between Hashimoto's thyroiditis and the development, presentation, management, and outcome of papillary thyroid carcinoma. METHODS:Two complementary analytic methods were used. The clinical study was a retrospective case-control study, including patients s...
journal_title:Surgery
pub_type: 杂志文章,meta分析
doi:10.1067/msy.2099.101431
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Alternative methods for abdominal wall closure may be necessary after emergency laparotomy. The purpose of this study was to determine the morbidity and outcome of emergency fascial closure with polypropylene mesh. METHODS:A retrospective review was performed of all patients undergoing emergency fascial clo...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:10.1016/s0039-6060(05)80043-1
更新日期:1995-10-01 00:00:00
abstract::Local low-dose streptokinase infusion (5000 to 6000 IU/hr) as compared to systemic streptokinase infusion (loading dose 250,000 IU/hr, maintenance dose 100,000 IU/hr) successfully relieved a total thrombotic abdominal aortic occlusion. No complications of bleeding or distal embolization occurred during streptokinase t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::The findings of decreased adenosine triphosphate (ATP) levels in liver, kidney, and other tissues of animals in hemorrhagic shock were the rationale for previous experimental attempts to improve cell function by administration of fluids that contained high concentrations of ATP. The beneficial effects of this resuscit...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract::Hyperparathyroid crisis is a rare, life-threatening condition that requires prompt removal of the involved parathyroid gland(s). This report describes a patient with hyperparathyroid crisis caused by a mediastinal parathyroid adenoma, which was localized before operation and removed at the initial operation, without n...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The physiologic assessment of anal sphincters in cases of posttraumatic fecal incontinence is a fundamental step in planning operative treatment. In this study, we evaluate the correlation between size of anal sphincter defect, anal pressures, and clinical symptoms in patients with posttraumatic fecal incont...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.05.020
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Propranolol has been shown previously to decrease the mobilization of hematopoietic progenitor cells (HPCs) after acute injury in rodent models; however, this acute injury model does not reflect the prolonged period of critical illness after severe trauma. Using our novel lung contusion/hemorrhagic shock/c...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.06.031
更新日期:2015-09-01 00:00:00
abstract::This study was undertaken to determine whether fat absorption is improved following longitudinal pancreaticojejunostomy. Ten consecutive patients with chronic pancreatitis underwent measurement of fat absorption (fecal fat, 14C-labeled phenylacetic dipalmitate oil absorption test) before and after operation. Fecal fat...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract::Hygroma renalis is an unusual benign tumor of the kidney. Only 24 cases have been reported previously in the world literature; 22 of these patients underwent nephrectomy. Two sisters, with the first known occurrence in siblings, are discussed and the world literature is reviewed. Our first patient underwent nephrectom...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Rib fractures are common and associated with significant pulmonary morbidity. We hypothesized that epidural analgesia would provide superior pain relief, and reduce the risk of subsequent pneumonia. METHODS:A prospective, randomized trial of epidural analgesia versus IV opioids for the management of chest w...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.surg.2004.05.019
更新日期:2004-08-01 00:00:00