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Effects of cholesteryl ester transfer protein TAQ1B polymorphism in renal transplant patients.

Abstract：

BACKGROUND:Dyslipidemia is an important complication in renal transplant patients. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester between high density lipoproteins and low density lipoproteins. The aim of this study was to investigate CETP Taq1B gene polymorphism and lipid abnormalities in renal transplant patients. METHODS:We studied 29 renal transplant patients and 29 healthy controls. CETP Taq1B polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism techniques. Serum lipid levels were measured enzymatically. Statistical analyses was performed by SPSS for Windows version 7.5. RESULTS:The frequencies of CETP Taq1B B1B1, B1B2, and B2B2 genotypes in patients were 44.8%, 34.5%, and 20.7%; and in control subjects, 37.9%, 37.9%, and 24.2%, respectively. The patients with B1B1 genotype displayed higher levels of total cholesterol (TC), triglycerides, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), and diastolic blood pressure (DBP). (P<.05). Also, patients showing a B1 allele had higher levels of TC, LDL-C, VLDL-C, and DBP compared to healthy controls (P<.05). CONCLUSION:We observed that CETP Taq1B B1 allele and B1B1 genotype have effects on the serum lipid profile among renal transplant patients.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Zeybek U,Isbir T,Ergen HA,Yilmaz H,Hekim N,Akoglu E

doi

10.1016/j.transproceed.2006.03.039

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1382-4

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)00334-4

journal_volume

38

pub_type

杂志文章

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