Risk factors for isolation of strains susceptible only to polymyxin among patients with Pseudomonas aeruginosa bacteremia.

abstract：:A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2003-09-01 00:00:00

abstract：:The penetration of ciprofloxacin into heart tissue (valve and myocardium), mediastinal fat, and sternal bone marrow was the object of a prospective nonrandomized study involving 36 patients undergoing mitral and/or aortic valve replacement. Patients were divided into two groups of 18. Group 1 patients were administere...

journal_title：Antimicrobial agents and chemotherapy

authors： Mertes PM,Voiriot P,Dopff C,Scholl H,Clavey M,Villemot JP,Canton P,Dureux JB

更新日期：1990-03-01 00:00:00

abstract：:Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Kariuki S,Okoro C,Kiiru J,Njoroge S,Omuse G,Langridge G,Kingsley RA,Dougan G,Revathi G

更新日期：2015-01-01 00:00:00

abstract：:A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin, lomefloxacin, and sparfloxacin against gram-positive bacteria. A-80556 was particularly active against Staphylococcus aureus (MIC f...

journal_title：Antimicrobial agents and chemotherapy

authors： Clement JJ,Tanaka SK,Alder J,Vojtko C,Beyer J,Hensey D,Ramer N,McDaniel D,Chu DT

更新日期：1994-05-01 00:00:00

abstract：:Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr

更新日期：1979-06-01 00:00:00

abstract：:The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tylewska S,Hjertén S,Wadström T

更新日期：1981-11-01 00:00:00

abstract：:The distributions of tet(M) and conjugative transposons related to Tn1545 were studied by hybridization in 47 clinical isolates of Streptococcus pneumoniae resistant to tetracycline. Resistance to tetracycline was always associated with resistance to minocycline and was due to the presence of the tet(M) gene. Associat...

journal_title：Antimicrobial agents and chemotherapy

authors： Poyart-Salmeron C,Trieu-Cuot P,Carlier C,Courvalin P

更新日期：1991-08-01 00:00:00

abstract：:Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

更新日期：1995-08-01 00:00:00

abstract：:There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

journal_title：Antimicrobial agents and chemotherapy

authors： Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

更新日期：2020-09-21 00:00:00

abstract：:A survey conducted between 1987 and 1994 at the University Hospital of Besançon, France, demonstrated a dramatic increase (from 0 to 42. 5%) in the prevalence of amoxicillin resistance among Salmonella spp. Of the 96 resistant isolates collected during this period (including 77 Typhimurium), 54 were found to produce T...

journal_title：Antimicrobial agents and chemotherapy

authors： Llanes C,Kirchgesner V,Plesiat P

更新日期：1999-10-01 00:00:00

abstract：:Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetra...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1986-07-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU in the liver and spleen. We examined whether streptomycin encapsulat...

journal_title：Antimicrobial agents and chemotherapy

authors： Gangadharam PR,Ashtekar DR,Flasher DL,Düzgüneş N

更新日期：1995-03-01 00:00:00

abstract：:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen Pseudomonas aeruginosa in the presence of the glycoprotein mucin, which is found in high abundance at mucosal surfaces, especially those of the lungs of cystic fibrosis and bronchiectasis patients. Here, we investigated the ada...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun E,Gill EE,Falsafi R,Yeung A,Liu S,Hancock REW

更新日期：2018-08-27 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:The resistance of Mycobacterium tuberculosis to isoniazid (INH) is largely linked to suppression of a catalase-peroxidase enzyme (KatG) that activates INH. In the absence of KatG, antioxidant protection is provided by enhanced expression of the peroxiredoxin AhpC, which is itself reduced by AhpD, a protein with low al...

journal_title：Antimicrobial agents and chemotherapy

authors： Koshkin A,Zhou XT,Kraus CN,Brenner JM,Bandyopadhyay P,Kuntz ID,Barry CE 3rd,Ortiz de Montellano PR

更新日期：2004-07-01 00:00:00

abstract：:The interrelationships between the pharmacokinetics of zidovudine alone and of zidovudine plus clarithromycin were evaluated with 18 volunteers with AIDS who had no infection with Mycobacterium avium complex or clinical evidence of gastroenteritis. Patients received 200 mg of zidovudine orally every 8 h on days 1 to 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Vance E,Watson-Bitar M,Gustavson L,Kazanjian P

更新日期：1995-06-01 00:00:00

abstract：:In 1989 and 1990, a large number of ampicillin-resistant strains of Enterococcus faecium were isolated from infected patients treated at intensive care units in Berlin, Germany. Twenty-five clinical isolates, including five different biotypes as classified by acid production from various sugars and a wide range of sus...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare I,Rodloff AC,Wagner J,Witte W,Hakenbeck R

更新日期：1992-04-01 00:00:00

abstract：:Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from human peripheral blood mononuclear cells. In the present study, we found that ciprofloxacin induced the production of prosta...

journal_title：Antimicrobial agents and chemotherapy

authors： Takahashi HK,Iwagaki H,Xue D,Katsuno G,Sugita S,Mizuno K,Mori S,Saito S,Yoshino T,Tanaka N,Nishibori M

更新日期：2005-08-01 00:00:00

abstract：:Despite the availability of new antifungal compounds, invasive aspergillosis carries high morbidity and mortality in hematopoietic stem cell transplant recipients. In vitro studies and animal models suggest that the adoptive transfer of natural killer (NK) cells might be a promising immunotherapeutic option in this se...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmidt S,Schubert R,Tramsen L,Lehrnbecher T

更新日期：2019-01-29 00:00:00

abstract：:We encountered three clinical isolates of methicillin-resistant Staphylococcus aureus which were susceptible to netilmicin and arbekacin in the absence of beta-lactam antibiotics but which were resistant to them in the presence of beta-lactam antibiotics. One of these strains, KU5801, was used to further investigate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Ida T,Okamoto R,Nonoyama M,Irinoda K,Kurazono M,Inoue M

更新日期：2002-05-01 00:00:00

abstract：:We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonten MJ,Gaillard CA,van Tiel FH,van der Geest S,Stobberingh EE

更新日期：1995-12-01 00:00:00

abstract：:Data for a total of 164 bloodstream infection cases due to carbapenem-resistant Enterobacteriaceae (CRE) from 2013 to 2017 were retrospectively collected from 36 tertiary hospitals in 19 provinces in China to evaluate the outcomes and risk factors for mortality by univariable and multivariable analysis. The most frequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang X,Wang Q,Cao B,Sun S,Zhang Y,Gu B,Li B,Liao K,Zhao F,Jin L,Jin C,Yang C,Pei F,Zhang Z,Wang H

更新日期：2018-12-21 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. After inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-05-01 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:Sixty-seven patients were treated with moxalactam in a noncomparative trial of hospitalized patients; 32 had endometritis or chorioamnionitis, 12 had skin and soft tissue infections, 5 had osteomyelitis, 5 had pneumonia, 5 had urinary tract infections, 4 had arthritis, 2 had sepsis from an unknown source, 1 had endoca...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier RL,Faro S,Sanders CV,Williams W,Derks F,Janney A,Aldridge K

更新日期：1982-04-01 00:00:00

abstract：:The physical and nutritional requirements of the antibiotic-producing slime mold Physarum gyrosum were examined to develop a liquid medium for this myxomycete. Liquid culture is desired to expedite a useful scale of production of antibiotic materials for ease of isolation and structure study. Culture conditions were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor RL,Mallette MF

更新日期：1976-10-01 00:00:00

abstract：:Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam, is approved for treating complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. To determine doses ...

journal_title：Antimicrobial agents and chemotherapy

authors： Larson KB,Patel YT,Willavize S,Bradley JS,Rhee EG,Caro L,Rizk ML

更新日期：2019-05-24 00:00:00

abstract：:The MICs of ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid for clinical isolates of Mycobacterium kansasii were determined by the radiometric (BACTEC) method. All drugs except azithromycin elicited MICs for 90% of the strains tested that were lower than previously reported achievable maximum c...

journal_title：Antimicrobial agents and chemotherapy

authors： Witzig RS,Franzblau SG

更新日期：1993-09-01 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:An innovative liposomal formulation of meglumine antimoniate (LMA) was recently reported to promote both long-term parasite suppression and reduction of infectivity to sand flies in dogs with visceral leishmaniasis. However, 5 months after treatment, parasites were still found in the bone marrow of all treated dogs. I...

journal_title：Antimicrobial agents and chemotherapy

authors： da Silva SM,Amorim IF,Ribeiro RR,Azevedo EG,Demicheli C,Melo MN,Tafuri WL,Gontijo NF,Michalick MS,Frézard F

更新日期：2012-06-01 00:00:00