Ginsenoside Rg1 inhibits proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-alpha.

abstract：:Anlotinib is a new oral tyrosine kinase inhibitor; this study was designed to characterize its pharmacokinetics and disposition. Anlotinib was evaluated in rats, tumor-bearing mice, and dogs and also assessed in vitro to characterize its pharmacokinetics and disposition and drug interaction potential. Samples were ana...

journal_title：Acta pharmacologica Sinica

authors： Zhong CC,Chen F,Yang JL,Jia WW,Li L,Cheng C,Du FF,Zhang SP,Xie CY,Zhang NT,Olaleye OE,Wang FQ,Xu F,Lou LG,Chen DY,Niu W,Li C

更新日期：2018-06-01 00:00:00

abstract：AIM:Epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent in green tea. The aim of this study is to investigate the effects of EGCG on proliferation and migration of the human colon cancer SW620 cells. METHODS:Proliferation and migration of SW620 cells were induced by the protease-activated receptor ...

journal_title：Acta pharmacologica Sinica

authors： Zhou F,Zhou H,Wang T,Mu Y,Wu B,Guo DL,Zhang XM,Wu Y

更新日期：2012-01-01 00:00:00

abstract：:The revolutionary induced pluripotent stem cell (iPSC) technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease phenotypes will finally position human disease pathology at the core of drug discovery. Cells used to t...

journal_title：Acta pharmacologica Sinica

authors： Zhang R,Zhang LH,Xie X

更新日期：2013-06-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：AIM:To simultaneously investigate the contribution of the alpha 1 chain of collagen type 1 (COL1A1) and alpha2-HS-glycoprotein (AHSG) genes to the variation of bone geometric parameters in both Caucasians and Chinese. METHODS:Six hundred and five Caucasian individuals from 157 nuclear families and 1228 Chinese subject...

journal_title：Acta pharmacologica Sinica

authors： Jiang H,Lei SF,Xiao SM,Chen Y,Sun X,Yang F,Li LM,Wu S,Deng HW

更新日期：2007-03-01 00:00:00

abstract：AIM:Omi is an ATP-independent serine protease that is necessary for neuronal function and survival. The aim of this study was to investigate the role of protease Omi in regulating differentiation of mouse neuroblastoma cells and to identify the substrate of Omi involved in this process. METHODS:Mouse neuroblastoma N2a...

journal_title：Acta pharmacologica Sinica

authors： Ma Q,Hu QS,Xu RJ,Zhen XC,Wang GH

更新日期：2015-08-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as neural apoptosis regulated convertase (NARC1), is a key modulator of cholesterol metabolism. PCSK9 increases the serum concentration of low-density lipoprotein cholesterol by escorting low-density lipoprotein receptors (LDLRs) from the membrane of he...

journal_title：Acta pharmacologica Sinica

authors： He NY,Li Q,Wu CY,Ren Z,Gao Y,Pan LH,Wang MM,Wen HY,Jiang ZS,Tang ZH,Liu LS

更新日期：2017-03-01 00:00:00

abstract：AIM:To investigate the effects of different muscarinic receptor (M) subtypes in the spinal cord on the scores of naloxone-precipitated morphine-withdrawal symptoms and the changes of nNOS expression in locus coeruleus (LC). METHODS:nNOS immunohistochemistry, intrathecal injection (it), and antisense oligonucleotides (...

journal_title：Acta pharmacologica Sinica

authors： Chou WB,Zeng YM,Duan SM,Zhou WH,Gu J,Yang GD

更新日期：2002-08-01 00:00:00

abstract：AIM:To investigate whether autologous transplantation of adult stem cells could improve post-infarcted heart function. METHODS:Bone marrow mononuclear cells (MNCs) were isolated from adult rabbits' tibias after coronary ligation. These cells were exposed to 5-azacytidine 10 micromol/L for 24 h on the third day of cult...

journal_title：Acta pharmacologica Sinica

authors： Lin GS,Lü JJ,Jiang XJ,Li XY,Li GS

更新日期：2004-07-01 00:00:00

abstract：AIM:The aim of the present study was to explore the mechanism for the Ca2+- dependent inactivation of the canonical transient receptor potential (TRPC) 7 channel expressed in human embryonic kidney 293 cells. METHOD:The whole-cell patch-clamp technique was used in the study. RESULTS:With Ca2+-free external solution, ...

journal_title：Acta pharmacologica Sinica

authors： Zhang H,Inoue R,Shi J,Jin XH,Li YQ

更新日期：2008-01-01 00:00:00

abstract：AIM:To investigate the effects of the cardiotonic steroid, ouabain, on cardiac differentiation of murine embyronic stem cells (mESCs). METHODS:Cardiac differentiation of murine ESCs was enhanced by standard hanging drop method in the presence of ouabain (20 μmol/L) for 7 d. The dissociated ES derived cardiomyocytes we...

journal_title：Acta pharmacologica Sinica

authors： Lee YK,Ng KM,Lai WH,Man C,Lieu DK,Lau CP,Tse HF,Siu CW

更新日期：2011-01-01 00:00:00

abstract：AIM:To study the effects of cimetidine (Cim) on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by splenocytes in immune-derived aplastic anemic (AA) mice. METHODS:Aplastic anemic mice model was constructed first, and then the splenocytes were induced to secrete IFN gamma and...

journal_title：Acta pharmacologica Sinica

authors： Xia T,Wang QR,Xu YH

更新日期：2001-03-01 00:00:00

abstract：AIM:To investigate the effect of the Tob1 gene, a member of the Transducing Molecule of ErbB2/B-cell Translocation Ggene (TOB/BTG) family, by using the adenovirus-mediated expression of Tob1 on radiosensitivity in a human breast cancer cell line MDA-MB-231. METHODS:Cell survival was determined by clonogenic assay. Apo...

journal_title：Acta pharmacologica Sinica

authors： Jiao Y,Ge CM,Meng QH,Cao JP,Tong J,Fan SJ

更新日期：2007-10-01 00:00:00

abstract：AIM:To investigate the protection of pulmonary arterial rings and cardiac myocytes of rats by raisanberine (RS), a derivative of berberine, against hypoxia injury and to elucidate the action mechanisms. METHODS:Adult SD rats were exposed to intermittent hypoxia for 17 d or 28 d. The pulmonary arterial rings were isola...

journal_title：Acta pharmacologica Sinica

authors： Gao J,Tang YQ,Dai DZ,Cheng YS,Zhang GL,Zhang C,Dai Y

更新日期：2012-05-01 00:00:00

abstract：AIM:To investigate the inhibitory effect of the natural product Leukamenin F on liver fibrosis and explore its potential underlying mechanisms. METHODS:Carbon tetrachloride (CCl(4))-treated mouse model in vivo and in hepatic stellate cells (HSC) in vitro were used. The effect on CCl(4)-induced liver fibrosis was studi...

journal_title：Acta pharmacologica Sinica

authors： Liu Q,Wang X,Zhang Y,Li CJ,Hu LH,Shen X

更新日期：2010-07-01 00:00:00

abstract：AIM:To study the expressions of vascular endothelial growth factor (VEG F), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tie-1, and Tie-2 in C57BL/6 mouse brain after permanent focal cerebral ischemia. METHODS:The mRNA levels of VEGF, Ang-1, Ang-2, Tie-1, and Tie-2 were measured by semiquantitative reverse transcri...

journal_title：Acta pharmacologica Sinica

authors： Wang RG,Zhu XZ

更新日期：2002-05-01 00:00:00

abstract：AIM:To acquire the specific RNA aptamers inhibiting human red blood cell (RBC) acetylcholinesterase (AChE). METHODS:Systematic evolution of ligands by exponential enrichment (SELEX) aptamer against human red blood cell membrane AChE was selected by microtiter plate method in vitro. The specifity binding to AChE was de...

journal_title：Acta pharmacologica Sinica

authors： Zhang XM,Shao NS,Chi MG,Sun MJ

更新日期：2003-07-01 00:00:00

abstract：AIM:The conventional method for analyzing 24-h ambulatory blood pressure monitoring (24-h ABPM) is insufficient to deal with the large amount of data collected. The aim of this study was to develop a novel cyclic fluctuation model for 24-h ABPM in Chinese patients with mild to moderate hypertension. METHODS:The data w...

journal_title：Acta pharmacologica Sinica

authors： Sheng YC,Wang K,Xu L,Yang J,He YC,Zheng QS

更新日期：2013-08-01 00:00:00

abstract：AIM:To evaluate the pharmacokinetics of L-threonate after single or multiple oral administrations and its safety profile in healthy Chinese volunteers. METHODS:This was an open-label, single- and multiple-dose study. The subjects were assigned to receive a single dose, 675, 2025, or 4050 mg, of calcium L-threonate (n=...

journal_title：Acta pharmacologica Sinica

authors： Wang HY,Hu P,Jiang J

更新日期：2011-12-01 00:00:00

abstract：AIM:Previous study has shown that endometrial cancers with LKB1 inactivation are highly responsive to mTOR inhibitors. In this study we examined the effect of LKB1 gene status on mTOR inhibitor responses in non-small cell lung cancer (NSCLC) cells. METHODS:Lung cancer cell lines Calu-1, H460, H1299, H1792, and A549 we...

journal_title：Acta pharmacologica Sinica

authors： Xiao P,Sun LL,Wang J,Han RL,Ma Q,Zhong DS

更新日期：2015-09-01 00:00:00

abstract：AIM:To evaluate the pharmacokinetic interactions between theophylline and antofloxacin in vivo and in vitro. METHODS:A randomized, 5-day treatment and 3-way crossover design was documented in 12 healthy subjects. The subjects were orally administered with antofloxacin (400 mg on d 1 and 200 mg on d 2 to 5), theophylli...

journal_title：Acta pharmacologica Sinica

authors： Liu L,Pan X,Liu HY,Liu XD,Yang HW,Xie L,Cheng JL,Fan HW,Xiao DW

更新日期：2011-10-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), a rapidly progressing clonal malignancy of CD4+ T lymphocytes. Exploring the host-HTLV-1 interactions and the molecular mechanisms underlying HTLV-1-mediated tumorigenesis is critical for developing efficien...

journal_title：Acta pharmacologica Sinica

authors： Zhang LL,Wei JY,Wang L,Huang SL,Chen JL

更新日期：2017-08-01 00:00:00

abstract：AIM:Our previous study indicated that there are two types of Ca2+ release events seen in intact mouse bladder tissue. In this study our aim is to investigate the mechanism that underlies the phenomena of Ca2+ release in smooth muscle. METHODS:Single cells were isolated and tissue segments were prepared by cutting the ...

journal_title：Acta pharmacologica Sinica

authors： Wang M,Chen Z,Xing Y,Zhang X,Dong XZ,Ji GJ

更新日期：2006-07-01 00:00:00

abstract：AIM:To evaluate the therapeutic effects of gamichunggantang (GCT) on hyperlipidemia through high cholesterol diet model. GCT is an Oriental herbal medication, which has been used for the treatment of fatty liver, hyperlipidemia or alcoholic liver disease in Daejeon University Oriental Hospital, Korea since 1999. METHO...

journal_title：Acta pharmacologica Sinica

authors： Son CG,Choi WJ,Shin JW,Han SH,Cho JH,Song KC,Cho CK

更新日期：2003-02-01 00:00:00

abstract：:Binding of a neurotransmitter to its ionotropic receptor opens a distantly located ion channel, a process termed allosteric activation. Here we review recent advances in the molecular mechanism by which the cys-loop receptors are activated with emphasis on the best studied nicotinic acetylcholine receptors (nAChRs). W...

journal_title：Acta pharmacologica Sinica

authors： Chang YC,Wu W,Zhang JL,Huang Y

更新日期：2009-06-01 00:00:00

abstract：AIM:To investigate the effects of small interfering RNA of cyclooxygenase-2 (COX-2) on the proliferation and apoptosis of human multiple myeloma RPMI8226 cells and its relation with the Bcl-2 family in vitro. METHODS:Transcription and expression of COX-2 in human myeloma RPMI8226 cells were checked by RT-PCR and Weste...

journal_title：Acta pharmacologica Sinica

authors： Li QB,Chen ZC,You Y,Zou P

更新日期：2007-07-01 00:00:00

abstract：AIM:To study the influence of angiotensin (Ang) II receptor antagonist (AT1) valsartan and angiotensin-converting enzyme (ACE) inhibitor fosinopril on the cardiac hypertrophy induced by catecholamine. METHODS:A cardiac hypertrophy model was produced by i.p. norepinephrine (NE) 1.5 mg.kg-1.d-1 x 15 d. The animals were ...

journal_title：Acta pharmacologica Sinica

authors： Xiang Y,Huang J

更新日期：2000-09-01 00:00:00

abstract：AIM:To investigate molecular mechanism of testis development and spermatogenesis. METHODS:A human testis cDNA microarray was hybridized with probes from human adult testis, embryo testis and human sperm, and the differential expressed clones were sequenced and analyzed. Expression of PIAS-NY gene was analyzed by RT-PC...

journal_title：Acta pharmacologica Sinica

authors： Zheng Y,Zhou ZM,Yin LL,Li JM,Sha JH

更新日期：2004-08-01 00:00:00

abstract：:Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo efficacies of SHR-A140...

journal_title：Acta pharmacologica Sinica

authors： Yang CY,Wang L,Sun X,Tang M,Quan HT,Zhang LS,Lou LG,Gou SH

更新日期：2019-07-01 00:00:00

abstract：AIM:To study the effects and mechanisms by which hyposmotic challenge modulate function of L-type calcium current (I(Ca,L)) in rat ventricular myocytes. METHODS:The whole-cell patch-clamp techniques were used to record I(Ca,L) in rat ventricular myocytes. RESULTS:Hyposmotic challenge(∼220 mosmol/L) induced biphasic c...

journal_title：Acta pharmacologica Sinica

authors： Luo AT,Luo HY,Hu XW,Gao LL,Liang HM,Tang M,Hescheler J

更新日期：2010-11-01 00:00:00