Abstract：
:Ultrasound-induced blood stasis has been observed for more than 30 years. Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To date, experimental observations have been either in vitro or invasive. The current work demonstrates ultrasound-induced blood stasis in murine normal leg muscle versus tumor-bearing legs, observed through noninvasive measurements of optical spectroscopy, and discusses possible diagnostic uses for this previously undesirable effect of ultrasound. We demonstrate that, using optical spectroscopy, effects of ultrasound can be used to differentiate tumor from normal leg muscle tissue in mice. Finally, we propose a novel diagnostic algorithm that quantitatively differentiates tumor from nontumor with maximum specificity 0.83, maximum sensitivity 0.79, and area under receiver-operating-characteristics curve 0.90.
journal_name
Med Physjournal_title
Medical physicsauthors
Winey BA,Misic V,Liao L,Parker K,Fenton BM,Yu Ydoi
10.1118/1.2198196subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1623-33issue
6eissn
0094-2405issn
2473-4209journal_volume
33pub_type
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