Neutropenia during treatment of rheumatoid arthritis with levamisole.

abstract：OBJECTIVES:To compare glucose tolerance and parameters of insulin sensitivity and β-cell function between chronic glucocorticoid (GC)-using and GC-naive patients with rheumatoid arthritis (RA). METHODS:Frequently sampled 75 g oral glucose tolerance tests were performed in 58 chronic GC-using and 82 GC-naive patients w...

journal_title：Annals of the rheumatic diseases

authors： Hoes JN,van der Goes MC,van Raalte DH,van der Zijl NJ,den Uyl D,Lems WF,Lafeber FP,Jacobs JW,Welsing PM,Diamant M,Bijlsma JW

更新日期：2011-11-01 00:00:00

abstract：:Peritoneal serositis is not a widely recognised aspect of systemic lupus erythematosus (SLE). Indeed, ascites in SLE is said to occur only when complicated by the nephrotic syndrome, congestive cardiac failure, or hepatic cirrhosis. We describe two patients who developed ascites that could be attributed to none of the...

journal_title：Annals of the rheumatic diseases

authors： Mier A,Weir W

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:The eumusc.net project is an initiative founded by the European Community and the European League Against Rheumatism. One aim of the project was to facilitate equal standards for musculoskeletal health across Europe. The aim of this work-package was to develop patient-centred and consensus based standards of ...

journal_title：Annals of the rheumatic diseases

authors： Stoffer MA,Smolen JS,Woolf A,Ambrozic A,Berghea F,Boonen A,Bosworth A,Carmona L,Dougados M,de Wit M,Erwin J,Fialka-Moser V,Ionescu R,Keenan AM,Loza E,Moe RH,Greiff R,Olejnik P,Petersson IF,Rat AC,Rozman B,Strömb

更新日期：2015-06-01 00:00:00

abstract：:Four hundred and forty unrelated British Caucasoid patients with rheumatoid arthritis (RA) have been HLA typed for class I and class II antigens. Analyses of HLA antigen associations were performed on the overall group and in patient subsets selected according to particular disease parameters or sex, or both. The resu...

journal_title：Annals of the rheumatic diseases

authors： Jaraquemada D,Ollier W,Awad J,Young A,Silman A,Roitt IM,Corbett M,Hay F,Cosh JA,Maini RN

更新日期：1986-08-01 00:00:00

abstract：:Orally bioavailable compounds that target key intracellular signalling molecules are receiving increasing attention for the treatment of rheumatic diseases. The mitogen activated protein (MAP) kinases are especially attractive because they regulate both cytokine production and cytokine action. The MAP kinases are expr...

journal_title：Annals of the rheumatic diseases

authors： Sweeney SE,Firestein GS

更新日期：2006-11-01 00:00:00

abstract：:A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA...

journal_title：Annals of the rheumatic diseases

authors： Helliwell M,Coombes EJ,Moody BJ,Batstone GF,Robertson JC

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVE:To assess the usefulness of high resolution computed tomography (HRCT) of the lungs in patients with rheumatoid arthritis (RA) with and without respiratory symptoms. PATIENTS AND METHODS:Eighty eight RA patients with a mean duration of disease 12 (SD 8) years were evaluated. Eleven patients were excluded bec...

journal_title：Annals of the rheumatic diseases

authors： Cortet B,Flipo RM,Rémy-Jardin M,Coquerelle P,Duquesnoy B,Rêmy J,Delcambre B

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：:Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment. A new era in rheumatoid arthritis (RA) and related chronic autoimmune/inflammatory diseases is now beginning, with a variety of anti-TNFalpha treatments licensed for use in both RA and Crohn's disease. The rationale f...

journal_title：Annals of the rheumatic diseases

authors： Feldmann M,Bondeson J,Brennan FM,Foxwell BM,Maini RN

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To study the association between silica exposure, separately as well as combined with smoking, and the risk of developing rheumatoid arthritis (RA) with or without the presence of antibodies against citrullinated peptide antigens (ACPA). METHODS:This Swedish population based case-control study analysed 577 i...

journal_title：Annals of the rheumatic diseases

authors： Stolt P,Yahya A,Bengtsson C,Källberg H,Rönnelid J,Lundberg I,Klareskog L,Alfredsson L,EIRA Study Group.

更新日期：2010-06-01 00:00:00

abstract：:A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtain...

journal_title：Annals of the rheumatic diseases

authors： Million R,Nilsen KH,Jayson MI,Baker RD

更新日期：1981-10-01 00:00:00

abstract：:An explant method for the isolation of fibroblasts from adult human tendon is described. Cells were successfully isolated from 22 out of 27 common biceps tendons obtained from cadaveric donors (age range 11-83 years). The fibroblasts could be maintained in culture using standard methods and morphologically resembled t...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Wright JK,Hazleman BL

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVES:To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS:Yearly follow up was conduct...

journal_title：Annals of the rheumatic diseases

authors： Alarcón GS,Tracy IC,Strand GM,Singh K,Macaluso M

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. METHOD:The screening questionnaire was based on signs and symptoms, previous diagnosis of OA and validated OA criteria. A random sample of telephone nu...

journal_title：Annals of the rheumatic diseases

authors： Roux CH,Saraux A,Mazieres B,Pouchot J,Morvan J,Fautrel B,Testa J,Fardellone P,Rat AC,Coste J,Guillemin F,Euller-Ziegler L,KHOALA Osteoarthritis Group.

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis. METHODS:159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged ...

journal_title：Annals of the rheumatic diseases

authors： Amin S,Niu J,Guermazi A,Grigoryan M,Hunter DJ,Clancy M,LaValley MP,Genant HK,Felson DT

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5), a chemokine receptor expressed on T cells and macrophages, and its ligands are found in inflamed synovial tissue (ST) of patients with rheumatoid arthritis (RA). The rationale for testing CCR5 blockade in patients with RA was supported by the effects of a CCR5 antagonist ...

journal_title：Annals of the rheumatic diseases

authors： van Kuijk AW,Vergunst CE,Gerlag DM,Bresnihan B,Gomez-Reino JJ,Rouzier R,Verschueren PC,van der Leij C,Maas M,Kraan MC,Tak PP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE:To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the exp...

journal_title：Annals of the rheumatic diseases

authors： Yatabe T,Mochizuki S,Takizawa M,Chijiiwa M,Okada A,Kimura T,Fujita Y,Matsumoto H,Toyama Y,Okada Y

更新日期：2009-06-01 00:00:00

abstract：:While rheumatoid-factor-producing haemolytic plaque-forming cells (RF--PFC) of the human peripheral blood were easily inhibited by cycloheximide, mouse spleen cells immune to sheep red cells (anti-SRC PFC) were inhibited only after prolonged preincubation in the drug. The RF--PFC were easily inhibited by propranolol, ...

journal_title：Annals of the rheumatic diseases

authors： Moore TL,Rose JE,Vaughan JH

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVES:To determine if the presence of low percentages of CD8 positive cells or high levels of soluble interleukin-2 receptors (sIL-2R) define a subgroup of patients with more severe polymyalgia rheumatica and giant cell arteritis (PMR/GCA). METHODS:38 PMR/GCA patients were followed up prospectively. Serum levels ...

journal_title：Annals of the rheumatic diseases

authors： Salvarani C,Boiardi L,Macchioni P,Rossi F,Tartoni P,Casadei Maldini M,Mancini R,Beltrandi E,Portioli I

更新日期：1995-08-01 00:00:00

abstract：AIM:to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design. METHODS:All patients from the Dutch Rheumatoid Arthritis Monitoring (DREAM) register starting on tumour necrosis factor (TNF)alpha-blocking...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,Adang EM,Fransen J,Kuper HH,van de Laar MA,Jansen TL,De Gendt CM,De Rooij DJ,Brus HL,Van Oijen PC,Van Riel PC

更新日期：2008-09-01 00:00:00

abstract：:Cell electrophoresis identifies two main subpopulations of blood polymorphonuclear cells (PMNs), which in terms of the speed of their anodic migration are referred to as the fast and slow population. When blood PMNs from normal healthy subjects were incubated in medium containing 20% RA serum there was a decrease in t...

journal_title：Annals of the rheumatic diseases

authors： Brown KA,McCarthy D,Perry JD,Dumonde DC

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Gut involvement in inflammatory myositis is rare but causes significant morbidity and mortality. CASE REPORT:A case of eosinophilic gastroenteritis and polymyositis occurring in the same patient is described. The interface of visceral and striated muscle involvement is discussed. The pathophysiology of eosi...

journal_title：Annals of the rheumatic diseases

authors： Sofat N,Pitcher M,Price A,El-Jabbour JN,Higgens CS

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:To describe the influence of the reading order (chronological v paired) on radiographic scoring results in ankylosing spondylitis. To investigate whether this method is sufficiently sensitive to change because paired reading is requested for establishing drug efficacy in clinical trials. METHODS:Films obtai...

journal_title：Annals of the rheumatic diseases

authors： Wanders A,Landewé R,Spoorenberg A,de Vlam K,Mielants H,Dougados M,van der Linden S,van der Heijde D

更新日期：2004-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

journal_title：Annals of the rheumatic diseases

authors： Suurmond J,Schuerwegh AJ,Toes RE

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To show whether intra-articular steroid injections are effective in osteoarthritis; to determine factors that predict response; and to determine whether injection has a beneficial effect on muscle strength. METHODS:Double blind, placebo controlled, crossover study in 59 patients with symptomatic osteoarthri...

journal_title：Annals of the rheumatic diseases

authors： Jones A,Doherty M

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA). METHODS:Patients with active early RA (disease duration of ≤12 months) were randomly assigned ...

journal_title：Annals of the rheumatic diseases

authors： Detert J,Bastian H,Listing J,Weiß A,Wassenberg S,Liebhaber A,Rockwitz K,Alten R,Krüger K,Rau R,Simon C,Gremmelsbacher E,Braun T,Marsmann B,Höhne-Zimmer V,Egerer K,Buttgereit F,Burmester GR

更新日期：2013-06-01 00:00:00

abstract：:Chemotactic migration of leucocytes largely depends on adhesive interaction with the substratum and recognition of a chemoattractant gradient. Both aspects, cell adhesion and chemotaxis, are regulated by members of the family of chemotactic cytokines (chemokines) comprising structurally related and secreted proteins o...

journal_title：Annals of the rheumatic diseases

authors： Moser B,Willimann K

更新日期：2004-11-01 00:00:00

abstract：:A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

journal_title：Annals of the rheumatic diseases

authors： Peh WC,Shek TW,Ip WY

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

journal_title：Annals of the rheumatic diseases

authors： de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:In juvenile idiopathic arthritis (JIA), the efficacy of very early disease-modifying drug therapy, synthetic or biological, is not well known. Three alternative strategies were compared for treating recent-onset polyarticular JIA. METHODS:In a 54-week multicentre open-label clinical trial, 60 disease-modify...

journal_title：Annals of the rheumatic diseases

authors： Tynjälä P,Vähäsalo P,Tarkiainen M,Kröger L,Aalto K,Malin M,Putto-Laurila A,Honkanen V,Lahdenne P

更新日期：2011-09-01 00:00:00