Abstract:
OBJECTIVES:The purpose of this study was to determine quality of life (QOL) and exercise performance (EP) in patients with persistent atrial fibrillation (AF) converted to sinus rhythm (SR) compared with those remaining in or reverting to AF. BACKGROUND:Restoration of SR in patients with AF improving QOL and EP remains controversial. METHODS:Patients with persistent AF were randomized double-blind to amiodarone, sotalol, or placebo. Those not achieving SR at day 28 were cardioverted and classified into SR or AF groups at 8 weeks (n = 624) and 1 year (n = 556). The QOL (SF-36), symptom checklist (SCL), specific activity scale (SAS), AF severity scale (AFSS), and EP were assessed. RESULTS:Favorable changes were seen in SR patients at 8 weeks in physical functioning (p < 0.001), physical role limitations (p = 0.03), general health (p = 0.002), and vitality (p < 0.001), and at 1 year in general health (p = 0.007) and social functioning (p = 0.02). Changes in the scores for SCL severity (p = 0.01), functional capacity (p = 0.003), and AFSS symptom burden (p < 0.001) at 8 weeks and in SCL severity (p < 0.01) and AF symptom burden (p < 0.001) at 1 year showed significant improvements in SR versus AF. Symptomatic patients were more likely to have improvement. The EP in SR versus AF was greater from baseline to 8 weeks (p = 0.01) and to 1 year (p = 0.02). The EP correlated with physical functioning and functional capacity except in the AF group at 1 year. CONCLUSIONS:In patients with persistent AF, restoration and maintenance of SR was associated with improvements in QOL measures and EP. There was a strong correlation between QOL measures and EP.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Singh SN,Tang XC,Singh BN,Dorian P,Reda DJ,Harris CL,Fletcher RD,Sharma SC,Atwood JE,Jacobson AK,Lewis HD Jr,Lopez B,Raisch DW,Ezekowitz MD,SAFE-T Investigators.doi
10.1016/j.jacc.2006.03.051subject
Has Abstractpub_date
2006-08-15 00:00:00pages
721-30issue
4eissn
0735-1097issn
1558-3597pii
S0735-1097(06)01322-2journal_volume
48pub_type
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(91)90651-o
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journal_title:Journal of the American College of Cardiology
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更新日期:2009-11-17 00:00:00
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更新日期:2012-03-13 00:00:00