Interaction of bovine glutamate dehydrogenase with isoquinoline alkaloids.

abstract：:Factors influencing pyrroline 5-carboxylate (P5C) synthesis from glutamate by a subcellular fraction enriched in mitochondria of rat small intestinal mucosa have been studied. P5C synthesis decreased rapidly if this subcellular fraction was preincubated at 20 degrees C in the absence of substrates; this effect suggest...

journal_title：Archives of biochemistry and biophysics

authors： Henslee JG,Wakabayashi Y,Small C,Jones ME

更新日期：1983-10-15 00:00:00

abstract：:Geranyl pyrophosphate:(-)-endo-fenchol cyclase catalyzes the conversion of geranyl pyrophosphate to (-)-endo-fenchol by a process thought to involve the initial isomerization of the substrate to the tertiary allylic isomer, linalyl pyrophosphate, and the subsequent cyclization of this bound intermediate. Studies with ...

journal_title：Archives of biochemistry and biophysics

authors： Croteau R,Miyazaki JH,Wheeler CJ

更新日期：1989-03-01 00:00:00

abstract：:The effect of the nemaline myopathy-causing E117K mutation in β-tropomyosin (TM) on the structure and function of this regulatory protein was studied. The E117K mutant was found to have indistinguishable actin affinity compared with wild-type (WT) and similar secondary structure as measured by circular dichroism. Howe...

journal_title：Archives of biochemistry and biophysics

authors： Karpicheva OE,Robinson P,Piers A,Borovikov YS,Redwood CS

更新日期：2013-08-01 00:00:00

abstract：:The mechanism by which diverse drugs modulate voltage-dependent Ca2+ channels is ill-understood. We have approached this problem by examining the interaction of verapamil with a 97-residue synthetic channel peptide (SCP) that exhibits functional similarities to authentic L-type Ca2+ channels in terms of cation selecti...

journal_title：Archives of biochemistry and biophysics

authors： Zhorov BS,Ananthanarayanan VS

更新日期：1997-05-15 00:00:00

abstract：:Bovine heart muscle microsomes rapidly convert lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) in the presence of oleoyl-CoA. Both substrates are incorporated into the product, although the rate of incorporation of radiolabel into PC from 1-[14C]palmitoyl-LPC was approximately threefold higher than the rat...

journal_title：Archives of biochemistry and biophysics

authors： Sanjanwala M,Sun GY,Cutrera MA,MacQuarrie RA

更新日期：1988-09-01 00:00:00

abstract：:Under certain circumstances, added antioxidants can protect tissues against reoxygenation injury after ischemia. Yet reperfusing blood carries many antioxidants with it. The implications of this "antioxidant paradox" are discussed. ...

journal_title：Archives of biochemistry and biophysics

authors： Gutteridge JM,Halliwell B

更新日期：1990-12-01 00:00:00

abstract：:We tested the effects of a series of synthetic oligonucleotides (hybridons) complementary to the 5' noncoding and coding regions of rabbit beta-globin mRNA on endogenous protein synthesis in a rabbit reticulocyte cell-free translation system. With highly purified hybridons inhibition was completely specific for beta-g...

journal_title：Archives of biochemistry and biophysics

authors： Goodchild J,Carroll E 3rd,Greenberg JR

更新日期：1988-06-01 00:00:00

abstract：:A glucosyltransferase, which catalyzed the transfer of glucose from UDP-glucose (UDPG) to p-hydroxybenzoate (PHB) in cell cultures of Lithospermum erythrorhizon Sieb. et Zucc., Boraginaceae, was purified 219-fold by ammonium sulfate fractionation and chromatography on DEAE-Sephacel, Sephadex G-150, and phenyl-Sepharos...

journal_title：Archives of biochemistry and biophysics

authors： Bechthold A,Berger U,Heide L

更新日期：1991-07-01 00:00:00

abstract：:Casein kinase 1 phosphorylated rabbit skeletal muscle glycogen synthase at both seryl and threonyl residues. With glycogen synthase phosphorylated up to 7.5 mol phosphate/mol subunit, about 26% of the phosphate was present in the N-terminal cyanogen bromide fragment (CB1) and 74% in the C-terminal fragment (CB2). Both...

journal_title：Archives of biochemistry and biophysics

authors： Guasch MD,Plana M,Vila J,Itarte E

更新日期：1986-11-01 00:00:00

abstract：:The effects of the addition of hypolipidemic drugs and 1-acylglycerolipids on the metabolism of oleate in plants have been studied in vivo and in vitro. Using aged potato slices with [14C]oleate as a precursor, it was found that these drugs markedly inhibited both the incorporation into complex lipids and the desatura...

journal_title：Archives of biochemistry and biophysics

authors： Sánchez J,Stumpf PK

更新日期：1984-01-01 00:00:00

abstract：:Thioredoxin-1 (Trx-1) is a small redox oncoprotein whose expression is increased in a number of human primary cancers where it is associated with aggressive tumor growth, inhibition of apoptosis and decreased patient survival. We report that Trx-1-transfected MCF-7 human breast cancer cells have increased expression o...

journal_title：Archives of biochemistry and biophysics

authors： Berggren MI,Husbeck B,Samulitis B,Baker AF,Gallegos A,Powis G

更新日期：2001-08-01 00:00:00

abstract：:Aldehyde oxidase (EC 1.2.3.1) plays a role in the oxidation of aromatic heterocyclic compounds ingested by some higher vertebrates. To better understand this function, the specificity of the rabbit liver enzyme toward purines and their analogs was quantitatively studied. The chemical nature of the 6-substituent of pur...

journal_title：Archives of biochemistry and biophysics

authors： Hall WW,Krenitsky TA

更新日期：1986-11-15 00:00:00

abstract：:The effect of modulating AP-1 activity on the levels of induced erythroid and megakaryocytic differentiation of the erythroleukemia cell line K562 was examined. Cells were stably transfected with expression vectors encoding either a tetracycline-responsive dominant negative c-Jun (JunDN) or a hybrid Raf protein induci...

journal_title：Archives of biochemistry and biophysics

authors： Rosson D,O'Brien TG

更新日期：1998-04-15 00:00:00

abstract：:Geranylgeranyl diphosphate synthase supplies the essential acyclic precursor for Taxol biosynthesis in methyl jasmonate-induced Taxus canadensis suspension cell cultures. A cDNA encoding this prenyltransferase was cloned from an induced T. canadensis cell library. The recombinant enzyme expressed in yeast was confirme...

journal_title：Archives of biochemistry and biophysics

authors： Hefner J,Ketchum RE,Croteau R

更新日期：1998-12-01 00:00:00

abstract：:Activated leukocytes generate the potent oxidants HOCl and HOBr via the formation of H(2)O(2) and the release of peroxidase enzymes (myeloperoxidase, eosinophil peroxidase). HOCl and HOBr are potent microbiocidal agents, but excessive or misplaced production can cause tissue damage and cell lysis. In this study it is ...

journal_title：Archives of biochemistry and biophysics

authors： Hawkins CL,Brown BE,Davies MJ

更新日期：2001-11-15 00:00:00

abstract：:Some compounds are known to induce solute-nonselective permeability of the inner mitochondrial membrane (IMM) in Ca2+-loaded mitochondria. Existing data suggest that this process, following the opening of a mitochondrial permeability transition pore, is preceded by different solute-selective permeable states of IMM. A...

journal_title：Archives of biochemistry and biophysics

authors： Balakirev MY,Zimmer G

更新日期：1998-08-01 00:00:00

abstract：:The crystalline beef liver protein of Sumner and Dounce (A. L. Dounce, P. Z. Allen, and G. A. Mourtzikos (1978) Arch. Biochem. Biophys. 188, 251-265) termed FTBL (football) protein because of the shape of its crystals, has been identified as a crystalline leucine aminopeptidase (LAP), on the basis of its high specific...

journal_title：Archives of biochemistry and biophysics

authors： Dounce AL,Allen PZ

更新日期：1987-08-15 00:00:00

abstract：:Previous studies in which dicyclohexylcarbodiimide (DCCD) was used to inactivate F1-ATPase enzymes have suggested that two glutamate residues in the beta-subunit are essential for catalysis. In the Escherichia coli F1-ATPase, these are residues beta-Glu-181 and beta-Glu-192. Oligonucleotide-directed mutagenesis was us...

journal_title：Archives of biochemistry and biophysics

authors： Parsonage D,Wilke-Mounts S,Senior AE

更新日期：1988-02-15 00:00:00

abstract：:The modification of reactive protein sulfhydryls by S-nitrosoglutathione and other NO donors has been studied by gel isoelectric focusing. S-nitrosylated, unmodified, and S-glutathiolated protein forms are differentiated by this method. With specific antibodies for the protein of interest, both S-nitrosylation and S-g...

journal_title：Archives of biochemistry and biophysics

authors： Ji Y,Akerboom TP,Sies H,Thomas JA

更新日期：1999-02-01 00:00:00

abstract：:Catechol 1,2-dioxygenase catalyzes the oxygenative ring cleavage of catechol to form cis,cis-muconic acid and is encoded by a catA gene. We have cloned a catA gene from Pseudomonas putida mt-2 using a PCR product of amino acid sequence-based primers as a probe. The amino acid sequence deduced from the 930 nucleotides ...

journal_title：Archives of biochemistry and biophysics

authors： Nakai C,Uyeyama H,Kagamiyama H,Nakazawa T,Inouye S,Kishi F,Nakazawa A,Nozaki M

更新日期：1995-08-20 00:00:00

abstract：:The physiological role of the peroxisomal fatty acyl-CoA beta-oxidizing system (FAOS) is not yet established. We speculated that there might be a relationship between peroxisomal degradation of long-chain fatty acids in the liver and the biosynthesis of bile acids. This was investigated using [1-14C]butyric acid and [...

journal_title：Archives of biochemistry and biophysics

authors： Hayashi H,Miwa A

更新日期：1989-11-01 00:00:00

abstract：:A rabbit liver UDP-glucuronosyltransferase cDNA that is related to human and rat UGT1A7 has been identified. The predicted amino acid sequence of the UGT1A7l displays 80% similarity to that encoded by human HP4 (UGT1A9), but 81% to that predicted for human UGT1A7 and 77% to the rat UGT1A7 (UGTA2). The exons encoding h...

journal_title：Archives of biochemistry and biophysics

authors： Bruck M,Li Q,Lamb JG,Tukey RH

更新日期：1997-08-15 00:00:00

abstract：:Phospholipase C-gamma1, a substrate for many growth factor receptor and nonreceptor tyrosine kinases, produces second messenger molecules that are elements of signal transduction pathways related to cell proliferation. The influence of deletion mutations, which do not intrude on the domains required for catalytic func...

journal_title：Archives of biochemistry and biophysics

authors： Horstman DA,Chattopadhyay A,Carpenter G

更新日期：1999-01-01 00:00:00

abstract：:Several plasma membrane phospholipids have been studied for their ability to modulate the activity of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. We show here that phosphatidylinositol phosphate (PIP), phosphatidylinositol bisphosphate (PIP2), and/or the phosphatidylinositol and PIP kinases are locali...

journal_title：Archives of biochemistry and biophysics

authors： Patton JL,Lester RL

更新日期：1992-01-01 00:00:00

abstract：:Isolated mitochondria loaded with Ca(2+) and then exposed to Fe(2+) show a transient release of Ca(2+). The magnitude of this response depends on the Ca(2+) loading and the kinetics of the response depends on the concentration of added Fe(2+). We investigated the Fe(2+)-induced Ca(2+) release mechanism by measuring mi...

journal_title：Archives of biochemistry and biophysics

authors： Gogvadze V,Walter PB,Ames BN

更新日期：2002-02-15 00:00:00

abstract：:We have previously shown that exposure of Clone 9 cells to hypoxia, cyanide, or azide results in an acute stimulation of glucose transport that is largely mediated by "activation" of glucose transporter (Glut1) sites preexisting in the plasma membrane. However, it is not known whether inhibition of oxidative phosphory...

journal_title：Archives of biochemistry and biophysics

authors： Hamrahian AH,Zhang JZ,Elkhairi FS,Prasad R,Ismail-Beigi F

更新日期：1999-08-15 00:00:00

abstract：:Cortactin is an F-actin binding protein that contributes to cytoskeleton remodelling. We identified five isoforms of mouse cortactin that differ in the number of tandem 37-amino acid repeats, named cortactin repeats. The transcription of minor isoforms with 4.5, 3.5 or 2.5 cortactin repeats was low in most adult tissu...

journal_title：Archives of biochemistry and biophysics

authors： Katsube T,Togashi S,Hashimoto N,Ogiu T,Tsuji H

更新日期：2004-07-01 00:00:00

abstract：:The major phenobarbital-inducible form of cytochrome P-450 (cytochrome P-450 PB) was purified to homogeneity from rat liver microsomes and rabbit antibodies prepared against the purified enzyme. Using these antibodies, an enzyme-linked immunosorbent assay (ELISA) was developed for the detection of cytochrome P-450 PB ...

journal_title：Archives of biochemistry and biophysics

authors： Seidel SL,Shawver LK,Shires TK

更新日期：1984-03-01 00:00:00

abstract：:Cancer cells exhibit extreme sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) over normal cells, highlighting TRAIL's potential as a novel and effective cancer drug. However, the therapeutic effect of TRAIL is limited due to drug resistance. In the present study, we sought to investigate ...

journal_title：Archives of biochemistry and biophysics

authors： Wu B,Xiong J,Zhou Y,Wu Y,Song Y,Wang N,Chen L,Zhang J

更新日期：2020-10-15 00:00:00

abstract：:Pyruvate carboxylase deficiency was previously reported to be the biochemical lesion in a yeast mutant, designated pyc, which cannot utilize ethanol, acetate, pyruvate, aspartate, or oxaloacetate as the sole carbon source [C. Wills and T. Melham (1985) Arch. Biochem. Biophys. 236, 782-791; C. Wills et al. (1986) Arch....

journal_title：Archives of biochemistry and biophysics

authors： Lim F,Rohde M,Morris CP,Wallace JC

更新日期：1987-10-01 00:00:00