Abstract:
:Programmed cell death occurs in the nervous system both in normal development as well as in pathologic conditions, and is a key issue related to both brain repair and neurodegenerative diseases. Modulation of cell death in the nervous system may involve neurotrophic factors and other peptides, neurotransmitters and neuromodulators, that activate various signal transduction pathways, which in turn interact with the cell death execution machinery. Here we discuss the role of the second messenger cyclic adenosine 3'5'-monophosphate (cAMP) in cell death, and summarize current evidence that cAMP is a nodal point of neuroprotective signaling pathways.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Silveira MS,Linden Rdoi
10.1007/0-387-30128-3_10subject
Has Abstractpub_date
2006-01-01 00:00:00pages
164-76eissn
0065-2598issn
2214-8019journal_volume
557pub_type
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