Abstract:
:The sarcomere stiffness was measured in single muscle fibres during the development of tetanic tension using a method insensitive to fibre inertia and viscosity. The stiffness was calculated as the ratio between tension changes and sarcomere length changes during a period of fast sarcomere elongation at constant velocity. The results show that, unlike previous measurements with step or sinusoidal length changes, the relation between relative force and relative stiffness on the tetanus rise is linear. Consequently, the development of stiffness upon stimulation is synchronous with the development of force. Since a substantial fraction of sarcomere compliance is localized in the myofilaments, this result can be accounted for by assuming that either myofilament compliance is highly non-linear or that crossbridges stiffness during the tetanus rise is not proportional to crossbridge tension.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Bagni MA,Cecchi G,Colombini B,Colomo Fdoi
10.1007/978-1-4684-6039-1_43subject
Has Abstractpub_date
1998-01-01 00:00:00pages
383-91; discussion 391-2eissn
0065-2598issn
2214-8019journal_volume
453pub_type
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