Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance.

Abstract:

:In two separate experiments, rats received either kainic acid (KA), 6-hydroxydopamine (6-OHDA) or control lesions bilaterally into either the anteromedial or ventrolateral neostriatum. Both ventrolateral neurotoxic lesions disrupted post-operative body weight regulation and the acquisition of a DRL-20 sec operant schedule of reinforcement. The pattern of operant responding suggested that these animals had an impairment in response sequencing or switching. Rats with anteromedial lesions manifested neither body-weight nor DRL impairments.

journal_name

Behav Brain Res

authors

Dunnett SB,Iversen SD

doi

10.1016/0166-4328(82)90024-9

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

213-26

issue

3

eissn

0166-4328

issn

1872-7549

pii

0166-4328(82)90024-9

journal_volume

6

pub_type

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