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Long-term results of monoclonal anti-Il2-receptor antibody versus polyclonal antilymphocyte antibodies as induction therapy in renal transplantation.

Abstract：

:We compared the influence of induction therapy on 5-year patient and graft survival as well as on renal function in 100 kidney graft recipients at low immunological risk treated with antilymphocyte globulin (n = 50) versus anti-IL-2R monoclonal antibody (n = 50) in a prospective multicenter study. Long-term immunosuppressive treatment included cyclosporine, mycophenolate mofetil, and a short course of steroids in all patients. Five year graft (86% vs 86%) and patient (94% vs 94%) survivals were identical in both study arms. Moreover, neither serum creatinine or proteinuria were significantly different between the two groups. Our results showed that the choice of the induction therapy seemed to not have a major impact on long-term outcomes among renal recipients at low immunological risk.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Al Najjar A,Etienne I,Le Pogamp P,Bridoux F,Le Meur Y,Toupance O,Mousson C,Caillard S,Hurault de Ligny B,Marlière JF,Lebranchu Y

doi

10.1016/j.transproceed.2006.06.133

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

2298-9

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)00779-2

journal_volume

38

pub_type

杂志文章

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