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Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury.

Abstract：

:Ischemic preconditioning renders the liver more tolerant to ischemia-reperfusion injury in warm and cold ischemia-reperfusion models. In general, the application of a 5 to 10-minute period of ischemia followed by 10 minutes of reperfusion confers early effective protection to the liver. Mechanisms responsible for this endogenous protective effect include: (1) transient nitric oxide production during liver preconditioning; (2) diminution of toxic reactive species generated on reperfusion; (3) remote effect on extrahepatic organs such as lung, kidney, and pancreas; (4) preservation of energy metabolism during ischemia; and (5) involvement of nuclear transcription factor and others.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Peralta C,Serafin A,Fernández-Zabalegui L,Wu ZY,Roselló-Catafau J

doi

10.1016/s0041-1345(03)00571-2

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

1800-2

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041134503005712

journal_volume

35

pub_type

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