Influence of total parenteral nutrition on tissue lipoprotein lipase activity during chronic and acute illness.

Abstract:

:This study examines the influence of total parenteral nutrition (TPN) compared with 5% dextrose (D5) infusion on skeletal muscle and adipose tissue lipoprotein lipase (LPL) activity in nutritionally depleted, injured and infected patients. The plasma concentrations of glucose, free fatty acid (FFA), triglyceride and insulin were also measured. During TPN, nutritionally depleted subjects showed an increase in adipose tissue LPL activity, "fat cell size," and plasma insulin concentration. Skeletal muscle LPL activity and plasma FFA concentration decreased. In comparison, trauma patients showed a less marked rise in adipose tissue LPL activity and skeletal muscle LPL activity increased. Infected patients had a much smaller rise in adipose tissue LPL activity than either of the other groups, and muscle activity rose. The depleted and injured patients showed a linear relationship between adipose tissue LPL activity and plasma insulin concentration and an inverse hyperbolic relationship between adipose tissue LPL activity and plasma FFA concentration.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Robin AP,Greenwood MR,Askanazi J,Elwyn DH,Kinney JM

doi

10.1097/00000658-198112000-00003

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

681-6

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

194

pub_type

杂志文章
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