Progression and resolution of changes in pulmonary function and structure due to pulmonary microembolism and blood transfusion.

Abstract:

:It was the purpose of this research to define the progression over several days of changes in pulmonary function and structure and to document the phases of recovery following transfusions to dogs of sublethal quantities of stored blood containing microaggregates. Ten dogs underwent partial exchange transfusions averaging 60% of blood volume through standard blood transfusion filters. Average screen filtration pressure (SFP) of the blood was 85 mm Hg. Pulmonary hypertension did not develop, but there were striking decreases in O2 consumption, increases in Qs/Qt and decreases in Do2. Changes became progressively more marked over the first 48 to 72 hours after the transfusions. Pulmonary function of surviving animals returned nearly to normal by the sixth day after transfusions. Pathologic examinations of the lungs of animals sequentially sacrificed over 6 days showed intravascular microemboli, alveolar cell hyperplasia and interstitial and alveolar pulmonary edema. Progressive recovery was associated with progressive resolution of all detrimental changes. In 6 animals exchange transfused 100% of their blood volumes through dacron wool (Swank) filters and in three control animals that were not transfused, there were no significant changes in pulmonary function or structure. These experiments define the progression of deterioration and recovery over 6 days of pulmonary function in dogs after sublethal pulmonary microembolism occurring during blood transfusion.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Brown C,Dhurandhar HN,Barrett J,Litwin MS

doi

10.1097/00000658-197701000-00016

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

92-99

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

185

pub_type

杂志文章
  • Meckel's diverticulum--a high-risk region for malignancy in the ileum. Insights from a population-based epidemiological study and implications in surgical management.

    abstract:BACKGROUND:Surgical management of incidental Meckel's diverticulum(MD) is a highly debated controversial issue that has never been discussed from the oncological standpoint. OBJECTIVE:To describe the epidemiology and risk of Meckel's diverticulum cancer (MDC) and compare it with other ileal malignancies. METHODS:Data...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181ef488d

    authors: Thirunavukarasu P,Sathaiah M,Sukumar S,Bartels CJ,Zeh H 3rd,Lee KK,Bartlett DL

    更新日期:2011-02-01 00:00:00

  • Extended Molecular Profiling Improves Stratification and Prediction of Survival After Resection of Colorectal Liver Metastases.

    abstract:OBJECTIVE:The aim of this study was to assess the effect of cancer-related genes and their mutations analyzed by next-generation sequencing (NGS) on the oncological outcome after resection of colorectal liver metastases (CRLM). BACKGROUND:Traditional prognostic scores include clinical and pathological parameters of pr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003527

    authors: Lang H,Baumgart J,Heinrich S,Tripke V,Passalaqua M,Maderer A,Galle PR,Roth W,Kloth M,Moehler M

    更新日期:2019-11-01 00:00:00

  • Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group.

    abstract:BACKGROUND:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers. METHODS:All consecutive patients with primary RPS treated...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001447

    authors: Gronchi A,Strauss DC,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Raut CP

    更新日期:2016-05-01 00:00:00

  • Surgical Complications in a Multicenter Randomized Trial Comparing Preoperative Chemoradiotherapy and Immediate Surgery in Patients With Resectable and Borderline Resectable Pancreatic Cancer (PREOPANC Trial).

    abstract:OBJECTIVES:To investigate the effect of preoperative chemoradiotherapy on surgical complications in patients after pancreatic resection for (borderline-)resectable pancreatic cancer. SUMMARY OF BACKGROUND DATA:Preoperative chemoradiotherapy is increasingly used in patients with (borderline-)resectable pancreatic cance...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004313

    authors: van Dongen JC,Suker M,Versteijne E,Bonsing BA,Mieog JSD,de Vos-Geelen J,van der Harst E,Patijn GA,de Hingh IH,Festen S,Ten Tije AJ,Busch OR,Besselink MG,van Tienhoven G,Groot Koerkamp B,van Eijck CHJ,Dutch Pancreatic Canc

    更新日期:2020-11-12 00:00:00

  • Cultured epidermis for the coverage of massive burn wounds. A single center experience.

    abstract::Seven patients with a mean burn size of 69.6% total body-surface area underwent skin grafting with autologous cultured epidermis. They were compared with a historical group of 18 controls, with a mean burn size of 60%, who underwent grafting with conventional meshed split-thickness autograft. There were no statistical...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199006000-00005

    authors: Munster AM,Weiner SH,Spence RJ

    更新日期:1990-06-01 00:00:00

  • Catecholamines: mediator of the hypermetabolic response to thermal injury.

    abstract::Hypermetabolism characterizes the metabolic response to thermal injury and the extent of energy production is positively related to the rate of urinary catecholamine excretion. Alpha and beta adrenergic blockade decreased metabolism from 69.6 +/- 5.3 Kcal/m(2)/hr to 57.4 +/- 5.2 (p < 0.01), and infusion of 6 microgm e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00031

    authors: Wilmore DW,Long JM,Mason AD Jr,Skreen RW,Pruitt BA Jr

    更新日期:1974-10-01 00:00:00

  • A Longitudinal Assessment of Outcomes and Healthcare Resource Utilization After Immediate Breast Reconstruction-Comparing Implant- and Autologous-based Breast Reconstruction.

    abstract:OBJECTIVES:Immediate breast reconstruction (IBR) after mastectomy for cancer has increased in recent years, yet long-term, modality-specific comparative data are lacking. We performed this study to compare short- and long-term outcomes after expander, autologous (AT), and direct-to-implant (DI) breast reconstruction. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001457

    authors: Fischer JP,Fox JP,Nelson JA,Kovach SJ,Serletti JM

    更新日期:2015-10-01 00:00:00

  • Inhibition of tumor angiogenesis and melanoma growth by targeting vascular E-selectin.

    abstract:OBJECTIVES:Aggressive human melanomas express, C-X-C chemokine receptor 4 (CXCR4), the receptor for the chemokine, stromal cell-derived factor-1alpha (SDF-1α). The CXCR4-SDF-1α axis has been postulated to increase melanoma invasiveness. We discovered that SDF-1α specifically upregulates E-selectin on endothelial cells,...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822a72dc

    authors: Liu ZJ,Tian R,Li Y,An W,Zhuge Y,Livingstone AS,Velazquez OC

    更新日期:2011-09-01 00:00:00

  • Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study.

    abstract::We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197701000-00021

    authors: Toledo-Pereyra LH,Simmons RL,Olson LC,Najarian JS

    更新日期:1977-01-01 00:00:00

  • The impact of neural invasion severity in gastrointestinal malignancies: a clinicopathological study.

    abstract:OBJECTIVES:Because neural invasion (NI) is still inconsistently reported and not well characterized within gastrointestinal malignancies (GIMs), our aim was to determine the exact prevalence and severity of NI and to elucidate the true impact of NI on patient's prognosis. BACKGROUND:The union internationale contre le ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000968

    authors: Liebl F,Demir IE,Mayer K,Schuster T,DʼHaese JG,Becker K,Langer R,Bergmann F,Wang K,Rosenberg R,Novotny AR,Feith M,Reim D,Friess H,Ceyhan GO

    更新日期:2014-11-01 00:00:00

  • Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms.

    abstract:OBJECTIVE:To compare outcomes of fenestrated (FEVAR) and open repairs of complex abdominal aortic aneurysms (cAAA). BACKGROUND:FEVAR has emerged as an alternative to open surgery for treating cAAA, but direct comparisons are limited. METHODS:We studied all repairs of intact or symptomatic cAAA in the Vascular Quality...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003094

    authors: O'Donnell TFX,Boitano LT,Deery SE,Schermerhorn ML,Schanzer A,Beck AW,Green RM,Takayama H,Patel VI

    更新日期:2020-05-01 00:00:00

  • Intestinal ischemia-reperfusion injury causes pulmonary endothelial cell ATP depletion.

    abstract::Intestinal ischemia-reperfusion is a common clinical event associated with both clinical and experimental distant organ injury. In particular, the pulmonary microvasculature appears to be susceptible to injury resulting from systemic inflammatory mediator activation. This study was designed to evaluate the hypothesis ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199301000-00009

    authors: Gerkin TM,Oldham KT,Guice KS,Hinshaw DB,Ryan US

    更新日期:1993-01-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

    abstract::Current treatment modalities for thrombotic thrombocytopenic purpura (TTP) include plasmapheresis (PP), splenectomy, steroids, dextran, other antiplatelet agents, and vinca alkaloids. Prior to the development of PP and use of multimodality treatment for TTP, mortality rates exceeded 50%. This report reviews 11 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00007

    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • Surgical strategy for hilar cholangiocarcinoma of the left-side predominance: current role of left trisectionectomy.

    abstract:OBJECTIVE:To evaluate recent surgical strategy for hilar cholangiocarcinoma (HC) of the left-side predominance. BACKGROUND:When employing left hemihepatectomy (LH) for HC, vasculobiliary anatomy of the right liver often makes it difficult to achieve a tumor-free margin of the right posterior sectional bile duct (RPSBD...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000584

    authors: Hosokawa I,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Yoshitomi H,Miyazaki M

    更新日期:2014-06-01 00:00:00

  • Smartphone-Based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVE:To determine the prevalence of clinically significant decision conflict (CSDC) among patients undergoing cancer surgery and associations with postoperative physical activity, as measured through smartphone accelerometer data. BACKGROUND:Patients with cancer face challenging treatment decisions, which may lea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004487

    authors: Panda N,Solsky I,Cauley CE,Lipsitz S,Desai EV,Huang EJ,Benjamin EM,Lubitz CC,Onnela JP,Haynes AB

    更新日期:2020-09-15 00:00:00

  • Adequacy of margins of resection in gastrectomy for cancer.

    abstract::This study determines the infiltration rate of proximal and distal margins of resection in patients operated on for gastric cancer at the Istituto Nazionale Tumori of Milan. Two hundred and eighty-five proximal margins and 286 distal margins were reviewed, and the incidence of infiltration was related to the length of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198212001-00012

    authors: Bozzetti F,Bonfanti G,Bufalino R,Menotti V,Persano S,Andreola S,Doci R,Gennari L

    更新日期:1982-12-01 00:00:00

  • Fifty years' experience with esophageal atresia and tracheoesophageal fistula. Beginning with Cameron Haight's first operation in 1935.

    abstract::Four hundred twenty-six patients with esophageal atresia with or without tracheoesophageal fistula have been primarily cared for at the University of Michigan Medical Center since Cameron Haight's initial experience with this entity. Over the period of observation, the incidence of new cases as well as the number of a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198610000-00013

    authors: Manning PB,Morgan RA,Coran AG,Wesley JR,Polley TZ Jr,Behrendt DM,Kirsh MM,Sloan HE

    更新日期:1986-10-01 00:00:00

  • Massive Ringer's lactate infusion: comparison with dextrose 5% and whole blood.

    abstract::The objectives of this study were to compare in dogs the effects of massive infusion of Ringer's lactate, 5% dextrose in water, and whole blood. Special interest centered upon lung function, central venous pressure, and dilutional effects upon the blood components. Three groups of 5 healthy dogs each received respecti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197511000-00018

    authors: Hardy JD,Hardy KP,Turner MD

    更新日期:1975-11-01 00:00:00

  • K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.

    abstract:OBJECTIVE:To evaluate clinical parameters, presurgical diagnostic tests, histologic findings, and the presence of K-ras oncogene mutations in cystic tumors of the pancreas to determine which best predict malignancy. SUMMARY BACKGROUND DATA:Because presurgical, intraoperative, and final pathologic differentiation is di...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199807000-00012

    authors: Bartsch D,Bastian D,Barth P,Schudy A,Nies C,Kisker O,Wagner HJ,Rothmund M

    更新日期:1998-07-01 00:00:00

  • Reversal of protein-energy malnutrition in children during treatment of advanced neoplastic disease.

    abstract::The effectiveness of enteral and parenteral feeding in supporting a satisfactory nutritional status and/or reversing protein-energy malnutrition was evaluated in 28 children, ages 1-19 (14 female) with advanced malignant disease (21 solid tumors, 7 leukemia-lymphoma). At the onset of treatment, 21 patients received in...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197912000-00018

    authors: Rickard KA,Grosfeld JL,Kirksey A,Ballantine TV,Baehner RL

    更新日期:1979-12-01 00:00:00

  • Posterior retroperitoneoscopic adrenalectomy: preferred technique for removal of benign tumors and isolated metastases.

    abstract:OBJECTIVE:Posterior retroperitoneoscopic adrenalectomy (PRA) is a minimally invasive approach to removal of the adrenal gland. This anatomically direct approach, popularized by Walz, minimizes dissection and affords early access to the adrenal vein. We report the largest experience to date of PRA in the United States. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818a1d2a

    authors: Perrier ND,Kennamer DL,Bao R,Jimenez C,Grubbs EG,Lee JE,Evans DB

    更新日期:2008-10-01 00:00:00

  • The 30-day versus in-hospital and 90-day mortality after esophagectomy as indicators for quality of care.

    abstract:OBJECTIVE:To describe causes of death in the first year after esophagectomy and determine the time frame that should be used for measurement of quality of surgery. A case-mix adjustment model was developed for the comparison between hospitals. BACKGROUND:The time period in which postoperative mortality should be measu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000482

    authors: Talsma AK,Lingsma HF,Steyerberg EW,Wijnhoven BP,Van Lanschot JJ

    更新日期:2014-08-01 00:00:00

  • Lessons learned from more than 1,000 pancreas transplants at a single institution.

    abstract:OBJECTIVE:To determine outcome in diabetic pancreas transplant recipients according to risk factors and the surgical techniques and immunosuppressive protocols that evolved during a 33-year period at a single institution. SUMMARY BACKGROUND DATA:Insulin-dependent diabetes mellitus is associated with a high incidence o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-200104000-00003

    authors: Sutherland DE,Gruessner RW,Dunn DL,Matas AJ,Humar A,Kandaswamy R,Mauer SM,Kennedy WR,Goetz FC,Robertson RP,Gruessner AC,Najarian JS

    更新日期:2001-04-01 00:00:00

  • Intraoperative gastrointestinal endoscopy.

    abstract::A four year experience with the adaptation of the flexible fiberoptic endoscope to the intraoperative environment is presented in 30 patients. The technique of intraoperative endoscopy was utilized in a wide variety of difficult gastrointestinal surgical problems to include the location of the site and cause of bleedi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198006000-00004

    authors: Bowden TA Jr,Hooks VH 3rd,Mansberger AR Jr

    更新日期:1980-06-01 00:00:00

  • APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). BACKGROUND:Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002245

    authors: Yamashita S,Chun YS,Kopetz SE,Maru D,Conrad C,Aloia TA,Vauthey JN

    更新日期:2020-12-01 00:00:00

  • Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?

    abstract:OBJECTIVE:To evaluate the influence of the response to preoperative chemotherapy, especially tumor progression, on the outcome following resection of multiple colorectal liver metastases (CRM). SUMMARY BACKGROUND DATA:Hepatic resection is the only treatment that currently offers a chance of long-term survival, althoug...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000145964.08365.01

    authors: Adam R,Pascal G,Castaing D,Azoulay D,Delvart V,Paule B,Levi F,Bismuth H

    更新日期:2004-12-01 00:00:00

  • Fibrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty: a randomized prospective trial.

    abstract:OBJECTIVE:To compare the clinical outcome of simultaneous bilateral endoscopic totally extraperitoneal inguinal hernioplasty (TEP) using fibrin sealant (FS) and mechanical stapling for prosthetic mesh fixation. SUMMARY BACKGROUND DATA:Similar efficacy of FS and mechanical stapling for mesh fixation has been demonstrat...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000186440.02977.de

    authors: Lau H

    更新日期:2005-11-01 00:00:00

  • Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia-driven phenomenon.

    abstract:OBJECTIVE:The aim of this study was to assess how thermal ablation of colorectal liver metastases affects the outgrowth of micrometastases in the transition zone (TZ) between ablated tissue and the unaffected reference zone (RZ) in 2 different murine models. BACKGROUND:Thermal destruction therapies of nonresectable co...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181a38ef5

    authors: Nijkamp MW,van der Bilt JD,de Bruijn MT,Molenaar IQ,Voest EE,van Diest PJ,Kranenburg O,Borel Rinkes IH

    更新日期:2009-05-01 00:00:00

  • Femoroperoneal bypass: evaluation of potential for revascularization of the severely ischemic lower extremity.

    abstract::In 79 patients in whom distal small vessel bypass with autogenous vein was used for revascularization because of gangrene, gangrenous ulceration or rest pain, 14 had femoroperoneal bypasses. Femorotibial or femoroperoneal bypasses were performed in those patients in whom no popliteal runoff was present on pre-operativ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197502000-00010

    authors: Reichle FA,Tyson RR

    更新日期:1975-02-01 00:00:00

  • Variation and Impact of Multiple Complications on Failure to Rescue After Inpatient Surgery.

    abstract:OBJECTIVE:To examine the extent to which multiple, sequential complications impacts variation in institutional postoperative mortality rates. BACKGROUND:Failure to rescue (FTR) has been proposed as an underlying factor in hospital variation in surgical mortality. However, little is currently known about hospital varia...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001917

    authors: Massarweh NN,Anaya DA,Kougias P,Bakaeen FG,Awad SS,Berger DH

    更新日期:2017-07-01 00:00:00