MRI and Diffusion-weighted MRI Volumetry for Identification of Complete Tumor Responders After Preoperative Chemoradiotherapy in Patients With Rectal Cancer: A Bi-institutional Validation Study.

Abstract:

BACKGROUND:Retrospective single-center studies have shown that diffusion-weighted magnetic resonance imaging (DWI) is promising for identification of patients with rectal cancer with a complete tumor response after neoadjuvant chemoradiotherapy (CRT), using certain volumetric thresholds. OBJECTIVE:This study aims to validate the diagnostic value of these volume thresholds in a larger, independent, and bi-institutional patient cohort. METHODS:A total of 112 patients with locally advanced rectal cancer (2 centers) treated with a long course of CRT were enrolled. Patients underwent standard T2W-magnetic resonance imaging and DWI, both pre- and post-CRT. Two experienced readers independently determined pre-CRT and post-CRT tumor volumes (cm) on T2W-magnetic resonance image and diffusion-weighted magnetic resonance image by means of freehand tumor delineation. Tumor volume reduction rates (Δvolume) were calculated. Previously determined T2W and DWI threshold values for prevolume, postvolume, and Δvolume were tested to "prospectively" assess their respective diagnostic value in discriminating patients with a complete tumor response from patients with residual tumor. RESULTS:Twenty patients had a complete response. Using the average measurements between the 2 readers, areas under the curve for the pre-/post-/Δvolumes was 0.73/0.82/0.78 for T2W-magnetic resonance imaging and 0.77/0.92/0.86 for DWI, respectively. For T2W-volumetry, sensitivity and specificity using the predefined volume thresholds were 55% and 74% for pre-, 60% and 89% for post-, and 60% and 86% for Δvolume. For DWI volumetry, sensitivity and specificity were 65% and 76% for pre-, 70% and 98% for post-, and 70% and 93% for Δvolume. CONCLUSIONS:Previously established DWI volume thresholds can be reproduced with good results. Post-CRT DWI volumetry offers the best results for the detection of patients with a complete response after CRT with an area under the curve of 0.92, sensitivity of 70%, and specificity of 98%.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Lambregts DM,Rao SX,Sassen S,Martens MH,Heijnen LA,Buijsen J,Sosef M,Beets GL,Vliegen RA,Beets-Tan RG

doi

10.1097/SLA.0000000000000909

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1034-9

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

262

pub_type

杂志文章,多中心研究
  • The effect of jejunoileal bypass on bile composition and the formation of billiary calculi.

    abstract::In our series of 101 patients with small bowel bypass for morbid obesity, nine developed biliary calculi postoperatively during a mean follow-up of 29.6 months. The development of gallstones depends in part on biliary cholesterol saturation and on the zeta potential of bile. In eight consecutive patients, the lithogen...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197801000-00011

    authors: Wise L,Stein T

    更新日期:1978-01-01 00:00:00

  • Ethics of Codes and Codes of Ethics: When Is It Ethical to Provide Cardiopulmonary Resuscitation During the COVID-19 Pandemic?

    abstract:OBJECTIVE:Our study aims to provide a paradigm when it is ethical to perform cardiopulmonary resuscitation (CPR) on patients during the COVID-19 pandemic. SUMMARY BACKGROUND DATA:Hospitals around the nation are enacting systems to limit CPR in caring for COVID+ patients for a variety of legitimate reasons and based on...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004318

    authors: Kopar PK,Brown DE,Turnbull IR

    更新日期:2020-12-01 00:00:00

  • Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients With Metastatic Pheochromocytoma or Sympathetic Paraganglioma.

    abstract:OBJECTIVE:To determine whether primary tumor resection in patients with metastatic pheochromocytoma or paraganglioma (PPG) is associated with longer overall survival (OS). BACKGROUND:Patients with metastatic PPG have poor survival outcomes. The impact of surgical resection of the primary tumor on OS is not known. MET...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002195

    authors: Roman-Gonzalez A,Zhou S,Ayala-Ramirez M,Shen C,Waguespack SG,Habra MA,Karam JA,Perrier N,Wood CG,Jimenez C

    更新日期:2018-07-01 00:00:00

  • Prolonged Air Leak After Pulmonary Resection Increases Risk of Noncardiac Complications, Readmission, and Delayed Hospital Discharge: A Propensity Score-adjusted Analysis.

    abstract:OBJECTIVE:The aim of the study was to determine whether prolonged air leak (PAL) is associated with postoperative morbidity and mortality following pulmonary resection after adjusting for differences in baseline characteristics using propensity score analysis. SUMMARY BACKGROUND DATA:Patients with PAL after lung resec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003191

    authors: Attaar A,Luketich JD,Schuchert MJ,Winger DG,Sarkaria IS,Nason KS

    更新日期:2021-01-01 00:00:00

  • Surgical treatment of gastroesophageal reflux in infants.

    abstract::Thirty-one infants less than a year of age underwent surgery for correction of pernicious gastroesophageal reflux. Severe growth retardation from persistent vomiting was the single most important indication for surgery (25 patients). Recurrent aspiration penumonitis was another serious sequella of reflux and necessita...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00013

    authors: Randolph JG,Lilly JR,Anderson KD

    更新日期:1974-10-01 00:00:00

  • Case managers in mass casualty incidents.

    abstract:OBJECTIVE:To examine whether case managers affect patient evaluation/treatment/outcome and staffing requirements during Multiple Casualty Incidents (MCIs). SUMMARY BACKGROUND DATA:Multiple patient relocations during MCIs may contribute to chaos. One hospital changed its MCI patient relocation policy during a wave of M...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31819a6f17

    authors: Einav S,Schecter WP,Matot I,Horn JK,Hersch M,Reissman P,Spira RM

    更新日期:2009-03-01 00:00:00

  • Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis.

    abstract::Celiotomy in cirrhotic patients is reported to bear a high risk of operative morbidity and mortality. We reviewed 100 consecutive, cirrhotic patients who underwent nonshunt celiotomy. Thirty patients died and major complications occurred in another 30 patients. Hospital mortality rate was 21% in 39 biliary operations,...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198406000-00003

    authors: Garrison RN,Cryer HM,Howard DA,Polk HC Jr

    更新日期:1984-06-01 00:00:00

  • Pregnancy As a Risk Factor for Small Bowel Obstruction After Laparoscopic Gastric Bypass Surgery.

    abstract:OBJECTIVE:To evaluate whether pregnancy is associated with increased risk for small bowel obstruction after laparoscopic gastric bypass surgery. BACKGROUND:Small bowel obstruction is a common and feared long-term complication to laparoscopic gastric bypass surgery that may be more common during pregnancy. It is unclea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003163

    authors: Stenberg E,Chen R,Hildén K,Fall K

    更新日期:2020-07-01 00:00:00

  • Multicenter Canadian study of prehospital trauma care.

    abstract:OBJECTIVE:To evaluate whether the type of on-site care a trauma patient receives affects outcome. SUMMARY BACKGROUND DATA:The controversy regarding the prehospital care of trauma patients between Advanced Life Support (ALS) and Basic Life Support (BLS) is ongoing. Due to this unresolved controversy, as well as histori...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.SLA.0000048374.46952.10

    authors: Liberman M,Mulder D,Lavoie A,Denis R,Sampalis JS

    更新日期:2003-02-01 00:00:00

  • Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria.

    abstract:INTRODUCTION:For patients with hepatocellular carcinoma (HCC) in particular, living donor liver transplant (LDLT) improves access to transplant. We report our results in 36 patients with HCC who underwent LDLT with a median follow-up >1 year. METHODS Underlying diagnoses included: hepatitis C (24), hepatitis B (9), cry...

    journal_title:Annals of surgery

    pub_type: 评论,杂志文章

    doi:10.1097/01.sla.0000109022.32391.eb

    authors: Gondolesi GE,Roayaie S,Muñoz L,Kim-Schluger L,Schiano T,Fishbein TM,Emre S,Miller CM,Schwartz ME

    更新日期:2004-02-01 00:00:00

  • A comparative study of the elective treatment of variceal hemorrhage with beta-blockers, transendoscopic sclerotherapy, and surgery: a prospective, controlled, and randomized trial during 10 years.

    abstract:OBJECTIVE:To compare three options for the elective treatment of portal hypertension during a 10-year period. METHODS:Patients included in the trial were 18 to 76 years old, had a history of bleeding portal hypertension, and had undergone no prior treatment. Treatment options were beta-blockers (propranolol), scleroth...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200008000-00011

    authors: Orozco H,Mercado MA,Chan C,Guillén-Navarro E,López-Martínez LM

    更新日期:2000-08-01 00:00:00

  • A stapling instrument for end-to-end inverting anastomoses in the gastrointestinal tract.

    abstract::A stapling instrument is described for end-to-end inverting anastomoses applicable principally to low rectal anastomosis or esophagogastric or esophagojejunal anastomosis. The instrument creates an inverting anastomosis held by a double staggered row of stainless steel wire staples creating an anastomosis 21.2 mm inte...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197906000-00017

    authors: Ravitch MM,Steichen FM

    更新日期:1979-06-01 00:00:00

  • Mucosal damage in the esophageal remnant after esophagectomy and gastric transposition.

    abstract:OBJECTIVE:To assess development of mucosal damage in the esophageal remnant in regard to the level of the esophagogastrostomy reconstruction either in a right chest or in a left neck position. SUMMARY BACKGROUND DATA:Esophagectomy with gastric interposition creates an in vivo human model of pathologic esophageal reflu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818eec06

    authors: D'Journo XB,Martin J,Rakovich G,Brigand C,Gaboury L,Ferraro P,Duranceau A

    更新日期:2009-02-01 00:00:00

  • Significant contribution of the portal vein to blood flow through the common bile duct.

    abstract:OBJECTIVE:The aim of this study was to determine the contribution of the hepatic artery, gastroduodenal artery, and portal vein to the microvascular blood flow in the common bile duct (CBD). BACKGROUND:Biliary complications are a common cause of graft loss after liver transplantation. The occurrence is, partly, attrib...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824714d0

    authors: Slieker JC,Farid WR,van Eijck CH,Lange JF,van Bommel J,Metselaar HJ,de Jonge J,Kazemier G

    更新日期:2012-03-01 00:00:00

  • Treatment of abdominal abscesses: comparative evaluation of operative drainage versus percutaneous catheter drainage guided by computed tomography or ultrasound.

    abstract::Computed tomography and, to a lesser extent, ultrasonography provide detailed anatomic localization of intra-abdominal abscesses that permit precise percutaneous placement of catheters large enough to effect drainage. Using routes similar to surgical approaches, the authors have used this technique as definitive thera...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198110000-00014

    authors: Johnson WC,Gerzof SG,Robbins AH,Nabseth DC

    更新日期:1981-10-01 00:00:00

  • The impact of the 80-hour resident workweek on surgical residents and attending surgeons.

    abstract:OBJECTIVE:To assess the impact of the 80-hour resident workweek restrictions on surgical residents and attending surgeons. SUMMARY BACKGROUND DATA:The ACGME mandated resident duty hour restrictions have required a major workforce restructuring. The impact of these changes needs to be critically evaluated for both the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000220042.48310.66

    authors: Hutter MM,Kellogg KC,Ferguson CM,Abbott WM,Warshaw AL

    更新日期:2006-06-01 00:00:00

  • Permanent Pancreatic Duct Occlusion With Neoprene-based Glue Injection After Pancreatoduodenectomy at High Risk of Pancreatic Fistula: A Prospective Clinical Study.

    abstract:OBJECTIVE:The aim of this study was to assess safety and efficacy of pancreatic duct occlusion (PDO) with neoprene-based glue in selected patients undergoing pancreatoduodenectomy (PD) at high risk of postoperative pancreatic fistula (POPF). BACKGROUND DATA:PD is the reference standard approach for tumors of the pancr...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003514

    authors: Mazzaferro V,Virdis M,Sposito C,Cotsoglou C,Droz Dit Busset M,Bongini M,Flores M,Prinzi N,Coppa J

    更新日期:2019-11-01 00:00:00

  • Vasodilator prostaglandins (PG) prevent renal damage after ischemia.

    abstract::Thromboxane (Tx) synthase but not cyclo-oxygenase inhibitors prevent acute tubular necrosis (ATN) after renal ischemia, a phenomenon believed to be due to stimulation of the endogenous production of vasodilating prostaglandins (PG). This study directly tests that vasodilating PG protect against the consequences of ren...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198702000-00015

    authors: Kaufman RP Jr,Anner H,Kobzik L,Valeri CR,Shepro D,Hechtman HB

    更新日期:1987-02-01 00:00:00

  • Intra-aortic balloon counterpulsation: potential for therapy in hemorrhagic shock with associated myocardial failure.

    abstract::After attaching appropriate monitoring devices enabling the measurement of the slope of the left ventricular function curve, left atrial pressure, mean aortic pressure, peak left ventricular pressure, and tension time index, three groups of ten dogs were subjected to varying periods of hemorrhagic shock until a slope ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197501000-00025

    authors: Proctor HJ,Hsiao H,Fry J,Ebert C

    更新日期:1975-01-01 00:00:00

  • The Use of Caffeinated Substances by Surgeons for Cognitive Enhancement.

    abstract:OBJECTIVE:To investigate the use of coffee, caffeinated drinks, and caffeine tablets for pharmacological cognitive enhancement (CE) among surgeons. BACKGROUND:Surgeons have demanding workloads, and the resulting fatigue and concentration deficits can lead to medical errors. Some surgeons use substances that promote wa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000830

    authors: Franke AG,Bagusat C,McFarlane C,Tassone-Steiger T,Kneist W,Lieb K

    更新日期:2015-06-01 00:00:00

  • Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver.

    abstract::Total hepatic protein synthesis was measured in vivo with a flooding-dose technique, and the production of total secreted proteins, albumin, complement component C3, and seromucoid fraction was measured in perfused livers of septic rats that received one of three different solutions infused intravenously; Group 1 rece...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00007

    authors: Pedersen P,Li SJ,Hasselgren PO,LaFrance R,Fischer JE

    更新日期:1988-12-01 00:00:00

  • Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma.

    abstract:OBJECTIVE:This study determined whether the neurotensin gene (NT/N) is expressed in the normal adult liver and focal nodular hyperplasia (FNH) and confirmed NT/N expression in fibrolamellar carcinoma; whether NT/N or the neurotensin receptor is expressed in the fetal liver; and whether hepatic resection leads to expres...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199410000-00007

    authors: Ehrenfried JA,Zhou Z,Thompson JC,Evers BM

    更新日期:1994-10-01 00:00:00

  • Endocrine tumors of the duodenum. Clinical characteristics and hormone content.

    abstract::Nineteen patients with primary duodenal carcinoid were analysed retrospectively, and eight of the tumors were immunocytochemically examined. One tumor contained somatostatin, two tumors gastrin, two tumors both these peptides, and one tumor contained serotonin. In two tumors no peptide or amine could be demonstrated. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00003

    authors: Lasson A,Alwmark A,Nobin A,Sundler F

    更新日期:1983-04-01 00:00:00

  • Personal experience with 411 hepatic resections.

    abstract::Over a 24-year period, 411 partial hepatic resections were performed: 142 right or left trisegmentectomies, 158 lobectomies, 25 segmentectomies, and 86 local excisions. The operations were performed for benign lesions in 182 patients, for primary hepatic malignancies in 106, and for hepatic metastases in 123, includin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198810000-00004

    authors: Iwatsuki S,Starzl TE

    更新日期:1988-10-01 00:00:00

  • Host defense against opportunist microorganisms following trauma. II. Changes in complement and immunoglobulins in patients with abdominal trauma and in septic patients without trauma.

    abstract::Total hemolytic complement (CH50), conversion of C3 by inulin and cobra venom factor (CoVF), and immunochemical levels of Clq, C4, C2, C3, C5, factor B, properdin, C3b inactivator (KAF), and immunoglobulins (Igs) G, A, and M were measured in the sera of ten patients with abdominal trauma and ten medical patients with ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197807000-00017

    authors: Bjornson AB,Altemeier WA,Bjornson HS

    更新日期:1978-07-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

    abstract::Metabolic changes in six severely affected tetanus patients suffering from characteristic labile hypertension (maximum systolic blood pressure greater than 200 mmHG, maximum diurnal change in systolic pressure greater than 100 mmHg) were investigated. Daily urinary excretion of urea nitrogen increased gradually from t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

  • Can Laparoscopic Cholecystectomy Prevent Recurrent Idiopathic Acute Pancreatitis?: A Prospective Randomized Multicenter Trial.

    abstract:OBJECTIVE:The aim of the present trial was to ascertain whether laparoscopic cholecystectomy (LCC) can prevent recurrent attacks of idiopathic acute pancreatitis (IAP). SUMMARY:Up to 50% to 75% of IAP may be due to microlithiasis, which is undetectable by conventional imaging methods. METHODS:This randomized, prospec...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001469

    authors: Räty S,Pulkkinen J,Nordback I,Sand J,Victorzon M,Grönroos J,Helminen H,Kuusanmäki P,Nordström P,Paajanen H

    更新日期:2015-11-01 00:00:00

  • Textbook Outcomes Among Medicare Patients Undergoing Hepatopancreatic Surgery.

    abstract:OBJECTIVE:To define and test "Textbook Outcome" (TO)-a composite measure for healthcare quality-among Medicare patients undergoing hepatopancreatic resections. Hospital variation in TO and Medicare payments were analyzed. BACKGROUND:Composite measures of quality may be superior to individual measures for the analysis ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003105

    authors: Merath K,Chen Q,Bagante F,Beal E,Akgul O,Dillhoff M,Cloyd JM,Pawlik TM

    更新日期:2020-06-01 00:00:00

  • Surgical management of pheochromocytoma with the use of metyrosine.

    abstract::Despite recommended preoperative preparation with alpha-adrenergic blockers, severe hemodynamic instability may occur during operations to resect pheochromocytoma. We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patien...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199011000-00010

    authors: Perry RR,Keiser HR,Norton JA,Wall RT,Robertson CN,Travis W,Pass HI,Walther MM,Linehan WM

    更新日期:1990-11-01 00:00:00

  • Donating a Kidney to a Stranger: A Review of the Benefits and Controversies of Unspecified Kidney Donation.

    abstract:OF BACKGROUND DATA:Unspecified kidney donation (UKD) describes living donation of a kidney to a stranger. The practice is playing an increasingly important role within the transplant programme in the United Kingdom, where these donors are commonly used to trigger a chain of transplants; thereby amplifying the benefit d...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000003855

    authors: Maple H,Draper H,Gogalniceanu P,Burnapp L,Chilcot J,Mamode N

    更新日期:2020-07-01 00:00:00