Effects of glyceryl trinitrate and SIN-1A on musculature and vasculature of the dog trachea in situ.

abstract：:1. Dopamine is assumed to affect the ovary function after its conversion into noradrenaline (NA). 2. To study this bovine luteal slices from 11-14 days of the oestrous cycle were preincubated for 24 h to recover beta-receptors and next they were incubated for 1, 2 or 4 h with (a) different doses of dopamine; (b) dopam...

journal_title：British journal of pharmacology

authors： Kotwica J,Skarzynski D,Bogacki M,Miszkiel G

更新日期：1996-08-01 00:00:00

abstract：:1. Vasoconstrictions induced by transmural electrical field stimulation were frequency-dependent from 2 to 32 Hz in the rabbit isolated splenic artery. All contractions were abolished in the presence of tetrodotoxin 1 microM or guanethidine 100 microM. Stimulation at a frequency of more than 32 Hz induced both neuroge...

journal_title：British journal of pharmacology

authors： Ren LM,Burnstock G

更新日期：1997-02-01 00:00:00

abstract：:1. Glycine responses were studied under voltage clamp in Xenopus oocytes injected with cDNA encoding mammalian glycine receptor subunits and in rat medullary neurones. Bath application of glycine gave strychnine-sensitive currents which reversed close to the expected equilibrium potentials for chloride ions. The peak ...

journal_title：British journal of pharmacology

authors： Downie DL,Hall AC,Lieb WR,Franks NP

更新日期：1996-06-01 00:00:00

abstract：:The cardiotoxic effects of fenfluramine hydrochloride on mechanical and electrical activity were studied in papillary muscles, Purkinje fibres, left atria and ventricular myocytes of guinea-pigs. Force of contraction (f(c)) was measured isometrically, action potentials and maximum rate of rise of the action potential ...

journal_title：British journal of pharmacology

authors： Rajamani S,Studenik C,Lemmens-Gruber R,Heistracher P

更新日期：2000-03-01 00:00:00

abstract：:1. Histamine release by compound 48/80 was substantially reduced in a time-dependent manner (maximum at 30 min) by pre-incubating mast cells in calcium-free medium at 37 degrees C but not at 2 degrees C. This effect was optimal at pH 7.0 to 7.5. 2. The re-introduction of calcium (0.1 to 3 mmol/l) restored histamine re...

journal_title：British journal of pharmacology

authors： Garland LG,Payne AN

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Metabolic and cardiovascular abnormalities accompanying metabolic syndrome, such as obesity, insulin resistance and hypertension, are all associated with endothelial dysfunction and are independent risk factors for erectile dysfunction. The purpose of the present study was to investigate the vasc...

journal_title：British journal of pharmacology

authors： Contreras C,Sánchez A,Martínez P,Raposo R,Climent B,García-Sacristán A,Benedito S,Prieto D

更新日期：2010-09-01 00:00:00

abstract：:1 Picrotoxin selectively and reversibly suppressed the inhibitory action of gamma-aminobutyric acid (GABA), but not that of glycine, taurine or beta-alanine, on the frequency of spontaneous spike discharges in guinea-pig cerebellar slices. Strychnine reversibly suppressed the inhibitory action of glycine, taurine or b...

journal_title：British journal of pharmacology

authors： Okamoto K,Quastel JH

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a progressive fibro-proliferative disorder refractory to current therapy commonly complicated by the development of pulmonary hypertension (PH); the associated morbidity and mortality are substantial. Natriuretic peptides possess vasodilator and anti-fibroti...

journal_title：British journal of pharmacology

authors： Baliga RS,Scotton CJ,Trinder SL,Chambers RC,MacAllister RJ,Hobbs AJ

更新日期：2014-07-01 00:00:00

abstract：:1. Simultaneous computer modelling of control and guanfacine-masked [3H]-MK 912 saturation curves as well as guanfacine competition curves revealed that the drugs bound to two alpha 2-adrenoceptor subtypes in the rat cerebral cortex with very different selectivities. These alpha 2-adrenoceptor subtypes were designated...

journal_title：British journal of pharmacology

authors： Uhlén S,Xia Y,Chhajlani V,Felder CC,Wikberg JE

更新日期：1992-08-01 00:00:00

abstract：:1. We have taken advantage of our recent development of highly potent and specific phosphinic inhibitors of endopeptidase 3.4.24.15 to examine the putative contribution of the enzyme in the secretion of A beta by HK293 transfected cells overexpressing the wild type and the Swedish (Sw) double mutated form of beta APP7...

journal_title：British journal of pharmacology

authors： Chevallier N,Jiracek J,Vincent B,Baur CP,Spillantini MG,Goedert M,Dive V,Checler F

更新日期：1997-06-01 00:00:00

abstract：:1. The mechanism of toxicity of sulphur mustard was investigated by examining the biochemical effects of the analog 2-chloroethylethyl sulphide (CEES) in both human Jurkat cells as well as normal human lymphocytes. 2. Exposure of both types of cells to CEES resulted in a marked decrease in the intracellular concentrat...

journal_title：British journal of pharmacology

authors： Han S,Espinoza LA,Liao H,Boulares AH,Smulson ME

更新日期：2004-03-01 00:00:00

abstract：:1. The effects of pinacidil on noradrenaline-induced tone, smooth muscle membrane potential and 42K- and 86Rb-efflux from isolated mesenteric resistance vessels (internal diameter 200 microns) of the rat have been studied. 2. Pinacidil (0.3-10 microM) produced concentration-dependent suppression of noradrenaline-induc...

journal_title：British journal of pharmacology

authors： Videbaek LM,Aalkjaer C,Mulvany MJ

更新日期：1988-09-01 00:00:00

abstract：:1 The effects of gamma-aminobutyric acid (GABA) and related substances were examined in guinea-pig ileum longitudinal muscle.2 GABA at doses ranging from 10(-7) M to 3 x 10(-6) M elicited a relaxation while at higher doses (3 x 10(-6) M - 10(-4) M), as previously described, it caused a contraction followed by relaxati...

journal_title：British journal of pharmacology

authors： Giotti A,Luzzi S,Spagnesi S,Zilletti L

更新日期：1983-03-01 00:00:00

abstract：:(1) UNC-49B and UNC-49C are gamma-aminobutyric acid (GABA) receptor subunits encoded by the Caenorhabditis elegans unc-49 gene. UNC-49B forms a homomeric GABA receptor, or can co-assemble with UNC-49C to form a heteromeric receptor. The pharmacological properties of UNC-49B homomers and UNC-49B/C heteromers were inves...

journal_title：British journal of pharmacology

authors： Bamber BA,Twyman RE,Jorgensen EM

更新日期：2003-03-01 00:00:00

abstract：:Although previous reports have suggested that the sigma 1 (sigma(1)) receptor may be involved in pain sensation, its specific site of action has not been elucidated. The aim of present study was to determine the role of the spinal sigma(1) receptor in formalin-induced pain behavior, spinal cord Fos expression and phos...

journal_title：British journal of pharmacology

authors： Kim HW,Kwon YB,Roh DH,Yoon SY,Han HJ,Kim KW,Beitz AJ,Lee JH

更新日期：2006-06-01 00:00:00

abstract：:The stoichiometric relationship between adrenoceptors and saturable binding sites for 1,4-dihydropyridines in calcium channels was investigated in human ventricular myocardium. Membrane particles were prepared from heart specimens of patients undergoing open heart surgery. The patients suffered from hypertrophic obstr...

journal_title：British journal of pharmacology

authors： Ferry DR,Kaumann AJ

更新日期：1987-03-01 00:00:00

abstract：:Diabetes mellitus belongs to the most rapidly increasing diseases worldwide. Approximately 90-95% of these patients suffer from type 2 diabetes mellitus, which is characterized by peripheral insulin resistance and the progressive loss of beta-cell function and mass. Considering the complications of this chronic diseas...

journal_title：British journal of pharmacology

authors： Kaiser D,Oetjen E

更新日期：2014-06-01 00:00:00

abstract：:In perfused rabbit adrenal glands, colchicine (500 muM) inhibited the catecholamine secretion evoked by acetylcholine (20 mug/ml) but not that evoked by excess potassium (60 mM). Since both stimuli are believed to release catecholamines ultimately by the same secretory process, exocytosis, it is concluded that these i...

journal_title：British journal of pharmacology

authors： Douglas WW,Sorimachi M

更新日期：1972-05-01 00:00:00

abstract：:1. The effects of acetylcholine (ACh) on membrane potential, relaxation and cyclic GMP levels were compared to the NO donor L-nitrosocysteine (Cys-NO) in segments of guinea-pig coronary artery. 2. ACh and Cys-NO produced concentration-dependent relaxations of muscles contracted with the H1 receptor agonist, 2-(2-amino...

journal_title：British journal of pharmacology

authors： Eckman DM,Weinert JS,Buxton IL,Keef KD

更新日期：1994-04-01 00:00:00

abstract：:Bacteria have existed on Earth for three billion years or so and have become adept at protecting themselves against toxic chemicals. Antibiotics have been in clinical use for a little more than 6 decades. That antibiotic resistance is now a major clinical problem all over the world attests to the success and speed of ...

journal_title：British journal of pharmacology

authors： Bennett PM

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Glucocorticoids appear to control Na⁺ absorption in pulmonary epithelial cells via a mechanism dependent upon serum and glucocorticoid-inducible kinase 1 (SGK1), a kinase that allows control over the surface abundance of epithelial Na⁺ channel subunits (α-, β- and γ-ENaC). However, not all data s...

journal_title：British journal of pharmacology

authors： Watt GB,Ismail NA,Caballero AG,Land SC,Wilson SM

更新日期：2012-06-01 00:00:00

abstract：:1. Block by philanthotoxin-343 (PhTX-343), a neurotoxin from wasps, of ionic currents mediated through neuronal nicotinic acetylcholine (ACh) receptor/channels was characterized in rat phaeochromocytoma PC12 cells, by use of whole cell voltage-clamp techniques. 2. In the cells held at -60 mV, PhTX-343 at 0.1 and 1 mic...

journal_title：British journal of pharmacology

authors： Liu M,Nakazawa K,Inoue K,Ohno Y

更新日期：1997-09-01 00:00:00

abstract：:We have investigated the effects of methylenedioxymethamphetamine (MDMA, 'ecstasy'), i.v., on diastolic blood pressure (DBP) in pithed and pentobarbitone anaesthetized rats. In pithed rats, the non-selective 5-HT receptor antagonist methiothepin (0.1 mg kg(-1)) and the alpha2-adrenoceptor antagonists methoxyidazoxan a...

journal_title：British journal of pharmacology

authors： McDaid J,Docherty JR

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthe...

journal_title：British journal of pharmacology

authors： Benned-Jensen T,Rosenkilde MM

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway. This study investigated the effects of a PDE5 inhibitor on scopolamine-induced cognitive dysfunction, using memory-re...

journal_title：British journal of pharmacology

authors： Zhang L,Seo JH,Li H,Nam G,Yang HO

更新日期：2018-08-01 00:00:00

abstract：:1. Repeated allergen challenge has been shown to increase the role of Rho-kinase in airway smooth muscle (ASM) contraction. We considered the possibility that active allergic sensitization by itself, that is, without subsequent allergen exposure, could be sufficient to enhance Rho-kinase-mediated ASM contraction. 2. G...

journal_title：British journal of pharmacology

authors： Schaafsma D,Gosens R,Bos IS,Meurs H,Zaagsma J,Nelemans SA

更新日期：2004-10-01 00:00:00

abstract：:British Journal of Pharmacology (BJP) is pleased to publish a new set of guidelines for reporting research involving animals, simultaneously with several other journals; the 'ARRIVE' guidelines (Animals in Research: Reporting In Vivo Experiments). This editorial summarizes the background to the guidelines, gives our v...

journal_title：British journal of pharmacology

authors： McGrath JC,Drummond GB,McLachlan EM,Kilkenny C,Wainwright CL

更新日期：2010-08-01 00:00:00

abstract：:1. The atrioventricular node (AVN) is an important part of the conduction system in the heart and is a significant site of antiarrhythmic drug action. The class 1 antiarrhythmic propafenone is effective in treating a variety of arrhythmias, including those involving the AVN. In this study, we have investigated the eff...

journal_title：British journal of pharmacology

authors： Hancox JC,Mitcheson JS

更新日期：1997-05-01 00:00:00

abstract：:1. 5-Hydroxytryptamine (5-HT) stimulates active sodium transport and decreases the passive mucosal to serosal chloride permeability across frog skin. The relative importance of the different regions of the 5-HT molecule in the mediation of these responses has been studied using a range of structurally related compound...

journal_title：British journal of pharmacology

authors： Dalton T

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dexpramipexole, a drug recently tested in patients with amyotrophic lateral sclerosis (ALS,) is able to bind F1Fo ATP synthase and increase mitochondrial ATP production. Here, we have investigated its effects on experimental ischaemic brain injury. EXPERIMENTAL APPROACH:The effects of dexpramipe...

journal_title：British journal of pharmacology

authors： Muzzi M,Gerace E,Buonvicino D,Coppi E,Resta F,Formentini L,Zecchi R,Tigli L,Guasti D,Ferri M,Camaioni E,Masi A,Pellegrini-Giampietro DE,Mannaioni G,Bani D,Pugliese AM,Chiarugi A

更新日期：2018-01-01 00:00:00