The role of cell-fixed calcium in histamine release by compound 48/80.

abstract：BACKGROUND AND PURPOSE:PPAR-γ has been reported to be a protective regulator in ischaemia/reperfusion (I/R) injury. The receptor for advanced glycation end-products (RAGE) plays a major role in the innate immune response, and its expression is associated with PPAR-γ activation. Several angiotensin receptor blockers pos...

journal_title：British journal of pharmacology

authors： Koh EJ,Yoon SJ,Lee SM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emesis is a multi-system reflex, which is usually investigated using in vivo models. The aim of the study is to compare the response induced by emetic compounds across species and investigate whether dogs, ferrets and rats are all similarly predictive of humans. EXPERIMENTAL APPROACH:A systemati...

journal_title：British journal of pharmacology

authors： du Sert NP,Holmes AM,Wallis R,Andrews PL

更新日期：2012-03-01 00:00:00

abstract：:A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong...

journal_title：British journal of pharmacology

authors： Mariotto S,Cuzzolin L,Adami A,Del Soldato P,Suzuki H,Benoni G

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of Na(+)-K(+)-ATPase is known to attenuate endothelium-dependent relaxation in many arteries. The purpose of this study was to evaluate the role of Na(+)-K(+)-ATPase in the regulation of endothelial membrane potential at rest and during stimulation by ACh. EXPERIMENTAL APPROACH:Membra...

journal_title：British journal of pharmacology

authors： Bondarenko A,Sagach V

更新日期：2006-12-01 00:00:00

abstract：:1. The present experiments were designed to investigate the mechanisms causing intimal hyperplasia in connection with the impaired synergism between prostaglandin I2 (PGI2) and nitric oxide (NO) in human uterine arteries (UAs). 2. In order to assess the magnitude of intimal hyperplasia, the intima:media ratio (%) was ...

journal_title：British journal of pharmacology

authors： Obayashi S,Aso T,Sato J,Hamasaki H,Azuma H

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD). We have studied mechanisms implicated in vulnerability to stress and the relationship with changes in AD-related markers. EXPERIMENTAL APPROACH:Anhedonia induced by a chron...

journal_title：British journal of pharmacology

authors： Briones A,Gagno S,Martisova E,Dobarro M,Aisa B,Solas M,Tordera R,Ramírez M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pulmonary arterial hypertension (PAH, type 1 pulmonary hypertension) has a 3-year survival of ~50% and is in need of new, effective therapies. In PAH, remodelling of the pulmonary artery (PA) increases pulmonary vascular resistance and can result in right heart dysfunction and failure. Genetic mu...

journal_title：British journal of pharmacology

authors： Gorr MW,Sriram K,Muthusamy A,Insel PA

更新日期：2020-08-01 00:00:00

abstract：:1. The functional role of the nitric oxide (NO)/guanosine 3':5'-cyclic monophosphate (cyclic GMP) pathway in experimental myocardial ischaemia and reperfusion was studied in rat isolated hearts. 2. Rat isolated hearts were perfused at constant pressure with Krebs-Henseleit buffer for 25 min (baseline), then made ischa...

journal_title：British journal of pharmacology

authors： du Toit EF,McCarthy J,Miyashiro J,Opie LH,Brunner F

更新日期：1998-03-01 00:00:00

abstract：:1. Muscarinic receptors present in the human astrocytoma cell line 1321 N1 were characterized in radioligand binding studies and in functional studies of carbachol-stimulated phosphatidylinositol (PI) turnover. 2. In radioligand binding studies the muscarinic receptor in intact cells could be labelled using [3H]-N-met...

journal_title：British journal of pharmacology

authors： Kunysz EA,Michel AD,Whiting RL,Woods K

更新日期：1989-02-01 00:00:00

abstract：:Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB(1) and CB(2) receptors and of endogeno...

journal_title：British journal of pharmacology

authors： Pertwee RG

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Metabolic and cardiovascular abnormalities accompanying metabolic syndrome, such as obesity, insulin resistance and hypertension, are all associated with endothelial dysfunction and are independent risk factors for erectile dysfunction. The purpose of the present study was to investigate the vasc...

journal_title：British journal of pharmacology

authors： Contreras C,Sánchez A,Martínez P,Raposo R,Climent B,García-Sacristán A,Benedito S,Prieto D

更新日期：2010-09-01 00:00:00

abstract：:1. SB 206553 (5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2 ,3-f]indole) displays a high affinity (pK1 7.9) for the cloned human 5-HT2C receptor expressed in HEK 293 cells and the 5-HT2B receptor (pA2 8.9) as measured in the rat stomach fundus preparation. SB 206553 has low affinity for cloned human 5-HT...

journal_title：British journal of pharmacology

authors： Kennett GA,Wood MD,Bright F,Cilia J,Piper DC,Gager T,Thomas D,Baxter GS,Forbes IT,Ham P,Blackburn TP

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway. This study investigated the effects of a PDE5 inhibitor on scopolamine-induced cognitive dysfunction, using memory-re...

journal_title：British journal of pharmacology

authors： Zhang L,Seo JH,Li H,Nam G,Yang HO

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tooth eruption is a complicated process regulated by the dental follicles (DF). Our recent study discovered that tooth eruption was inhibited upon injection of bleomycin into DF. However, the mechanisms were unknown. EXPERIMENTAL APPROACH:Human dental follicle cells (hDFCs) were treated by bleom...

journal_title：British journal of pharmacology

authors： Li ZZ,Wang HT,Lee GY,Yang Y,Zou YP,Wang B,Gong CJ,Cai Y,Ren JG,Zhao JH

更新日期：2020-10-17 00:00:00

abstract：:1. Nociceptive thresholds to noxious mechanical (paw pressure) and thermal (tail flick) stimuli were recorded in conscious rats. The effects of three selective kappa-opioid receptor agonists on the responses to these stimuli were determined following intravenous, intracerebroventricular or intrathecal administration. ...

journal_title：British journal of pharmacology

authors： Leighton GE,Rodriguez RE,Hill RG,Hughes J

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is major evidence for the strong bi-directional interrelation of parenchymal cell apoptosis and leukocyte accumulation and inflammation in acute liver injury. Therefore, the aim of this in vivo study was to investigate the anti-apoptotic and anti-inflammatory potential of antileukoproteinas...

journal_title：British journal of pharmacology

authors： Eipel C,Kidess E,Abshagen K,Leminh K,Menger MD,Burkhardt H,Vollmar B

更新日期：2007-06-01 00:00:00

abstract：:1. Vanadium compounds can mimic actions of insulin through alternative signalling pathways. The effects of three organic vanadium compounds were studied in non-ketotic, streptozotocin-diabetic rats: vanadyl acetylacetonate (VAc), vanadyl 3-ethylacetylacetonate (VEt), and bis(maltolato)oxovanadium (VM). A simple inorga...

journal_title：British journal of pharmacology

authors： Reul BA,Amin SS,Buchet JP,Ongemba LN,Crans DC,Brichard SM

更新日期：1999-01-01 00:00:00

abstract：:LDL cholesterol (LDL-C) plays a central role in the progression of atherosclerosis. Statin therapy for lowering LDL-C reduces the risk of atherosclerotic cardiovascular disease and is the recommended first-line treatment for patients with high LDL-C levels. However, some patients are unable to achieve an adequate redu...

journal_title：British journal of pharmacology

authors： Nishikido T,Ray KK

更新日期：2019-08-29 00:00:00

abstract：:Conductance increases to gamma-aminobutyric acid (GABA) were recorded in the gm6b and opener muscle of the spiny lobsters, Panulirus interruptus and P. argus. GABA-evoked responses were insensitive to picrotoxin at concentrations as high as 5 X 10(-5) M. Some blockade by picrotoxin was observed at higher concentration...

journal_title：British journal of pharmacology

authors： Albert J,Lingle CJ,Marder E,O'Neil MB

更新日期：1986-04-01 00:00:00

abstract：:5-Lipoxygenase (5-LO) is a crucial enzyme in the synthesis of the bioactive leukotrienes (LTs) from arachidonic acid (AA), and inhibitors of 5-LO are thought to prevent the untowarded pathophysiological effects of LTs. In this study, we present the molecular pharmacological profile of the novel nonredox-type 5-LO inhi...

journal_title：British journal of pharmacology

authors： Fischer L,Steinhilber D,Werz O

更新日期：2004-07-01 00:00:00

abstract：:1. The present study was designed to characterize the positive inotropic response to DPI 201-106 in isolated papillary muscle strips obtained from heart failure patients undergoing surgery. 2. The positive inotropic responses to isoprenaline and milrinone and cardiac beta-adrenoceptor density were also determined. 3. ...

journal_title：British journal of pharmacology

authors： Böhm M,Diet F,Kemkes B,Wankerl M,Erdmann E

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. The aim of this study was to characteri...

journal_title：British journal of pharmacology

authors： Duggett NA,Flatters SJL

更新日期：2017-12-01 00:00:00

abstract：:In non-allergic subjects, histamine induced a reduction of minimal nasal cross-sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), 1 mumol but not by D-NAME, 1 mumol. L-NAME,...

journal_title：British journal of pharmacology

authors： Dear JW,Scadding GK,Foreman JC

更新日期：1995-09-01 00:00:00

abstract：:1. The 5-hydroxytryptamine (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), has been shown to label 5-HT reuptake sites. 2. To study the functional consequences of this property, the effects of 8-OH-DPAT were compared with those of the 5-HT reuptake inhibitors, paroxetine and clomipramine...

journal_title：British journal of pharmacology

authors： Assié MB,Koek W

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with diabetes mellitus are reported to show a raised prevalence of mental disorders, which may be reflected in impaired social interaction. However, the mechanisms underlying such impairment in diabetes are unknown. EXPERIMENTAL APPROACH:The present study investigated whether social int...

journal_title：British journal of pharmacology

authors： Ueda D,Yonemochi N,Kamata T,Shibasaki M,Kamei J,Waddington JL,Ikeda H

更新日期：2021-02-01 00:00:00

abstract：:1. ATP, UTP, ADP and ADP-beta-S elicited Ca2+ -signals in cultured aortic smooth muscle cells although ADP, UDP and ADP-beta-S gave approximately 40% of the maximal response seen with ATP and UTP. Adenosine, AMP or alpha,beta-methylene-ATP had no effect. These responses were attributed to P2Y2/4 and P2Y1 receptors, wh...

journal_title：British journal of pharmacology

authors： Pediani JD,McGrath JC,Wilson SM

更新日期：1999-04-01 00:00:00

abstract：:Cysteamine (beta-mercaptoethylamine HCl) (1.0-40.0 mM) induced a concentration-dependent increase in tonic and phasic contractions of segments of guinea-pig ileum in vitro. Myenteric plexus-longitudinal muscle (MPLM) preparations also responded with an increase in tonic contractions but phasic contractions were either...

journal_title：British journal of pharmacology

authors： Bakich V,Brown J,Kwok YN,McIntosh C,Nishimura E

更新日期：1984-08-01 00:00:00

abstract：:Authentic nitric oxide (NO; 0.1 - 10 micromoles) caused transient, dose-dependent relaxation of phenylephrine-induced tone without changing membrane potential in mesenteric arteries. Larger doses, above 10 micromoles, did not evoke more relaxation (maximal relaxation to 150 micromoles NO in denuded arteries, 69+/-7%, ...

journal_title：British journal of pharmacology

authors： Plane F,Sampson LJ,Smith JJ,Garland CJ

更新日期：2001-07-01 00:00:00

abstract：:1. It has been reported previously that the milrinone analogues, ethyl 5-cyano-1,6-dihydro-2-methyl-6-oxo-3 pyridine carboxylate (I) and ethyl 5-cyano-1,6-dihydro-2-ethyl-6-oxo-3 pyridine carboxylate (II) exert a positive inotropic effect (EC50 = 15.6 +/- 0.2 microM and 40.3 +/- 0.1 microM) both on spontaneously beati...

journal_title：British journal of pharmacology

authors： Dorigo P,Gaion RM,Belluco P,Mosti L,Borea PA,Maragno I

更新日期：1991-12-01 00:00:00

abstract：:1. The mechanism of toxicity of sulphur mustard was investigated by examining the biochemical effects of the analog 2-chloroethylethyl sulphide (CEES) in both human Jurkat cells as well as normal human lymphocytes. 2. Exposure of both types of cells to CEES resulted in a marked decrease in the intracellular concentrat...

journal_title：British journal of pharmacology

authors： Han S,Espinoza LA,Liao H,Boulares AH,Smulson ME

更新日期：2004-03-01 00:00:00