Abstract：
:1. ATP, UTP, ADP and ADP-beta-S elicited Ca2+ -signals in cultured aortic smooth muscle cells although ADP, UDP and ADP-beta-S gave approximately 40% of the maximal response seen with ATP and UTP. Adenosine, AMP or alpha,beta-methylene-ATP had no effect. These responses were attributed to P2Y2/4 and P2Y1 receptors, which we assumed could be selectively activated by UTP and ADP-beta-S respectively. 2. The response to UTP was reduced (approximately 50%) by pertussis toxin, whilst this toxin had no effect upon the response to ADP-beta-S. This suggests P2Y2/4 receptors simultaneously couple to pertussis toxin-sensitive and -resistant G proteins whilst P2Y1 receptors couple to only the toxin-resistant proteins. 3. Repeated stimulation with UTP or ADP-beta-S caused desensitization which was potentiated by 12-O-tetradecanoyl phorbol-13-acetate (TPA) and attenuated by staurosporine. 4. TPA completely abolished sensitivity to ADP-beta-S but the response to UTP had a TPA-resistant component. In pertussis toxin-treated cells, however, TPA could completely abolish sensitivity to UTP and so the TPA-resistant part of this response seems to be mediated by pertussis toxin-sensitive G proteins. 5. Loss of sensitivity to UTP did not occur when pertussis toxin-treated cells were repeatedly stimulated with this nucleotide, suggesting that pertussis toxin-sensitive G proteins mediate this effect. The toxin did not, however affect desensitization to ADP-beta-S.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Pediani JD,McGrath JC,Wilson SMdoi
10.1038/sj.bjp.0702470subject
Has Abstractpub_date
1999-04-01 00:00:00pages
1660-6issue
7eissn
0007-1188issn
1476-5381journal_volume
126pub_type
杂志文章abstract：:delta 9-Tetrahydrocannabinol (delta 9-THC) was injected into the preoptic area of the anterior hypothalamus or into the third or fourth cerebral ventricle of the conscious mouse through a chronically implanted cannula and the effects on body temperature and oxygen consumption rate were measured. At an ambient temperat...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1982.tb08802.x
更新日期：1982-02-01 00:00:00
abstract：:Animal and epidemiological studies suggest that polyphenol constituents of red wine possess antioxidant activities that favour protection against cardiovascular disease - the so-called. 'French paradox' - and possibly, central nervous system disorders such as Alzheimer's disease (AD) and ischaemia. In the present stud...
journal_title：British journal of pharmacology
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doi：10.1038/sj.bjp.0703626
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abstract：:1 Picrotoxin selectively and reversibly suppressed the inhibitory action of gamma-aminobutyric acid (GABA), but not that of glycine, taurine or beta-alanine, on the frequency of spontaneous spike discharges in guinea-pig cerebellar slices. Strychnine reversibly suppressed the inhibitory action of glycine, taurine or b...
journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1976.tb07650.x
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abstract：BACKGROUND AND PURPOSE:Mast cells are important in allergic reactions. Here, we assessed the anti-allergic effects of the anti-cancer drug tozasertib specifically regarding regulatory effects on mast cell activation. EXPERIMENTAL APPROACH:Tozasertib effects on mast cell degranulation were determined by measuring β-hex...
journal_title：British journal of pharmacology
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doi：10.1111/bph.15012
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1993.tb13962.x
更新日期：1993-12-01 00:00:00
abstract：:1. The aim of the study was to investigate the mechanism of a novel effect of hypoxia on intracellular Ca(2+) signalling in rabbit cerebral arteriolar smooth muscle cells, an effect that was resistant to the L-type Ca(2+) channel antagonist methoxyverapamil (D600). 2.[Ca(2+)](i) of smooth muscle cells in intact arteri...
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doi：10.1038/sj.bjp.0704547
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1991.tb09844.x
更新日期：1991-07-01 00:00:00
abstract：:The above article, published by the British Journal of Pharmacology in October 2015 (https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13259), has been retracted by agreement between the authors, the journal Editor in Chief and John Wiley & Sons Limited. The retraction has been agreed owing to the discovery...
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pub_type： 杂志文章,撤回出版物
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1996.tb16003.x
更新日期：1996-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1978.tb07779.x
更新日期：1978-05-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Anxiety disorder is a common mental health disorder. However, there are few safe and fast-acting anxiolytic drugs available that can treat anxiety disorder. We previously demonstrated that the interaction of neuronal NOS (nNOS) with its carboxy-terminal PDZ ligand (CAPON) is involved in regulatin...
journal_title：British journal of pharmacology
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更新日期：2020-08-01 00:00:00
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更新日期：2010-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1985.tb08955.x
更新日期：1985-11-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1111/bph.12056
更新日期：2013-12-01 00:00:00
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doi：10.1038/bjp.2008.281
更新日期：2008-10-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1978.tb08652.x
更新日期：1978-09-01 00:00:00
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doi：10.1038/sj.bjp.0702697
更新日期：1999-08-01 00:00:00
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更新日期：2002-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
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更新日期：1998-03-01 00:00:00
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更新日期：2010-04-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1969.tb08012.x
更新日期：1969-07-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1975.tb07363.x
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/bph.12692
更新日期：2015-01-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0706182
更新日期：2005-06-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1977.tb08390.x
更新日期：1977-03-01 00:00:00
abstract：:1. Calcium channel blockers increase cardiovascular morbidity and mortality in patients with left ventricular dysfunction. These adverse effects are probably related to the negative inotropic effect of calcium channel blockers and/or a neurohormonal activation. 2. The present study was designed to examine, in consciou...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1994.tb17002.x
更新日期：1994-10-01 00:00:00
