Abstract:
:A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO+) character of SNP could be responsible for its inhibition of NOS induction in neutrophils.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Mariotto S,Cuzzolin L,Adami A,Del Soldato P,Suzuki H,Benoni Gdoi
10.1111/j.1476-5381.1995.tb13320.xsubject
Has Abstractpub_date
1995-03-01 00:00:00pages
1105-6issue
6eissn
0007-1188issn
1476-5381journal_volume
114pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Kinins are pro-inflammatory peptides that are released during tissue injury, including that caused by inflammatory bowel disease. Herein, we assessed the role and underlying mechanisms through which the absence of kinin B(1) receptors exacerbates the development of dextran sulfate sodium (DSS)-i...
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journal_title:British journal of pharmacology
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更新日期:1980-03-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2012-06-01 00:00:00
abstract::The effects of pretreatment with 16,16-dimethyl prostaglandin E2 (DmPGE2) on the recovery of gastric mucosal 'barrier' parameters after ethanol-induced damage were studied using an ex vivo chamber preparation in the rat. DmPGE2 (4-40 micrograms kg-1) significantly reduced the extent of haemorrhagic damage to the gastr...
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更新日期:2013-12-01 00:00:00
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pub_type: 传,社论,历史文章
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abstract:BACKGROUND AND PURPOSE:Although CB(1) receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be peroxisome proliferator activated receptor (PPAR) ligands, offering an alternative protective mechanism. We have, therefore, investigated the ability of a range of can...
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更新日期:2007-11-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/bph.13849
更新日期:2018-06-01 00:00:00
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doi:10.1038/sj.bjp.0706843
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjp.0701183
更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjp.0706177
更新日期:2005-05-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2008-04-01 00:00:00
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doi:10.1038/sj.bjp.0703003
更新日期:2000-01-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2001-04-01 00:00:00
abstract::1. In some asthmatics, muscarinic receptor antagonists are effective in limiting bronchoconstrictor response, suggesting an abnormal cholinergic drive in these subjects. There is a growing body of evidences indicating that cholinergic neurotransmission is also enhanced by endothelin-1 (ET-1) in rabbit bronchi, mouse t...
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doi:10.1038/sj.bjp.0704395
更新日期:2001-12-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.2010.00910.x
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0702535
更新日期:1999-04-01 00:00:00
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-06-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0705713
更新日期:2004-04-01 00:00:00
abstract::1. The effector mechanism of intestinal necrosis in rat anaphylaxis was studied following several complementary approaches: (i) the use of monoclonal antibodies (mAb) belonging to different classes (IgG1, IgG2b and IgE anti-DNP), (ii) the assay of mediators, and (iii) the use of pharmacological tools. 2. Lethality and...
journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00