Pinacidil opens K+-selective channels causing hyperpolarization and relaxation of noradrenaline contractions in rat mesenteric resistance vessels.

abstract：:A linear correlation between amplitude of miotic response and initial pupil diameter has been demonstrated in rabbits using various concentrations of pilocarpine HC1. The same correlation was found when published results in humans using carbachol were examined and it is likely that the correlation also applies to pilo...

journal_title：British journal of pharmacology

authors： Burns J,Horlington M,Robson D

更新日期：1970-11-01 00:00:00

abstract：:1. The aim of the study was to investigate the mechanism of a novel effect of hypoxia on intracellular Ca(2+) signalling in rabbit cerebral arteriolar smooth muscle cells, an effect that was resistant to the L-type Ca(2+) channel antagonist methoxyverapamil (D600). 2.[Ca(2+)](i) of smooth muscle cells in intact arteri...

journal_title：British journal of pharmacology

authors： Guibert C,Flemming R,Beech DJ

更新日期：2002-02-01 00:00:00

abstract：:Constitutively active mu-opioid receptors (mu* receptors) are reported to be formed following prolonged agonist treatment of cells or whole animals. mu* receptors signal in the absence of activating ligand and a blockade of mu* activation of G-proteins by naloxone and naltrexone has been suggested to underlie the prof...

journal_title：British journal of pharmacology

authors： Connor M

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and non-responders have not been identified. The p...

journal_title：British journal of pharmacology

authors： Villaseñor A,Ramamoorthy A,Silva dos Santos M,Lorenzo MP,Laje G,Zarate C Jr,Barbas C,Wainer IW

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Injury to the alveolar epithelium is a critical feature of acute lung injury (ALI). Using a cytokine model of ALI we demonstrated previously that newly recruited mononuclear phagocytes (MNP) contributed to lung inflammation and injury. We hypothesized that cytokines delivered into the alveolar ai...

journal_title：British journal of pharmacology

authors： Parmley LA,Elkins ND,Fini MA,Liu YE,Repine JE,Wright RM

更新日期：2007-11-01 00:00:00

abstract：:1. The dihydropyridine calcium channel activator, Bay K 8644, is believed to increase mean arterial blood pressure in several animal models, as a result of direct activation of vascular smooth muscle cells by increasing calcium influx through the voltage-dependent calcium channels. The purpose of the current study was...

journal_title：British journal of pharmacology

authors： Moreland S,Ushay MP,Kimball SD,Powell JR,Moreland RS

更新日期：1988-04-01 00:00:00

abstract：:1. The type of endothelin (ET) receptor located on the myenteric neurones of guinea-pig ileum was determined by receptor autoradiography and function of the receptor was examined by release experiments of acetylcholine (ACh) from the longitudinal muscle myenteric plexus (LM-MP) preparations. 2. Specific [125I]-ET-1 bi...

journal_title：British journal of pharmacology

authors： Yoshimura M,Yamashita Y,Kan S,Niwa M,Taniyama K

更新日期：1996-07-01 00:00:00

abstract：:1. Membranes from rat cerebral cortex, myocardium and extraorbital lacrimal gland were used as sources of M1, M2 and M3 muscarinic acetylcholine receptors respectively and the affinities of seven antagonists for the three subtypes were examined under different experimental conditions. 2. The affinities for the membran...

journal_title：British journal of pharmacology

authors： Pedder EK,Eveleigh P,Poyner D,Hulme EC,Birdsall NJ

更新日期：1991-06-01 00:00:00

abstract：:1. In a rat model of experimental ileus, the effect of blockade of adrenergic and nitrergic neurotransmission was studied on the intestinal transit of Evans blue. 2. Ether anaesthesia and skin incision had no influence on the transit. Laparotomy significantly inhibited the transit of Evans blue. This inhibition was ev...

journal_title：British journal of pharmacology

authors： De Winter BY,Boeckxstaens GE,De Man JG,Moreels TG,Herman AG,Pelckmans PA

更新日期：1997-02-01 00:00:00

abstract：:1 ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y. Activation of P2X receptors has traditionally been associated with the well-characterised vasoconstrictor properties of ATP. 2 In the current study, we have shown that the P2X(1 & 3) receptor ligand, alpha, beta methylene ATP,...

journal_title：British journal of pharmacology

authors： Harrington LS,Mitchell JA

更新日期：2004-11-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') administration to rats produces hyperthermia if they are housed in normal or warm ambient room temperature (Ta) conditions (>or=20 degrees C), but hypothermia when in cool conditions (Ta

journal_title：British journal of pharmacology

authors： Green AR,O'Shea E,Saadat KS,Elliott JM,Colado MI

更新日期：2005-09-01 00:00:00

abstract：:781094 (2-(2(1, 4-benzodioxanyl))-2-imidazoline hydrochloride) is a potent competitive inhibitor of the aggregatory responses of human platelets induced by adrenaline (pA2 = 7.3) and UK-14304. 781094 is a more potent inhibitor of the pro-aggregatory response to clonidine than of that to methoxamine. The alpha 2/alpha ...

journal_title：British journal of pharmacology

authors： Kerry R,Scrutton MC

更新日期：1983-06-01 00:00:00

abstract：:1. The sensitivity of the guinea-pig vas deferens to noradrenaline, histamine, methylfurmethide and potassium was examined in vitro following decentralization and reserpine treatment.2. One day after decentralization or administration of reserpine (1.0 mg/kg daily) the sensitivity of the vas deferens was not increased...

journal_title：British journal of pharmacology

authors： Westfall DP

更新日期：1970-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:GABAA receptors mediate neuronal inhibition in the brain. They are the primary targets for benzodiazepines, which are widely used to treat neurological disorders including anxiety, epilepsy and insomnia. The mechanism by which benzodiazepines enhance GABAA receptor activity has been extensively s...

journal_title：British journal of pharmacology

authors： Dixon CL,Harrison NL,Lynch JW,Keramidas A

更新日期：2015-07-01 00:00:00

abstract：:1--Responses (relaxation) to the beta-adrenoceptor agonists, isoprenaline, fenoterol or noradrenaline, were obtained on cat tracheal preparations contracted with a submaximal concentration of carbachol (0.5 microM). 2--The relative potencies of isoprenaline: fenoterol: noradrenaline were 100:8.1:10.7. From this, it wa...

journal_title：British journal of pharmacology

authors： O'Donnell SR,Wanstall JC

更新日期：1983-02-01 00:00:00

abstract：:1. Angiotensin-converting enzyme (ACE) inhibitors exert their cardiovascular effects not only by preventing the formation of angiotensin II (AII), but also by promoting the accumulation of bradykinin in or at the vessel wall. In addition, certain ACE inhibitors have been shown to augment the vasodilator response to br...

journal_title：British journal of pharmacology

authors： Hecker M,Blaukat A,Bara AT,Müller-Esterl W,Busse R

更新日期：1997-08-01 00:00:00

abstract：:1. The ability of the nitric oxide (NO)-releasing aspirin, NCX 4016, to control vasoconstrictor responses induced by electrical field stimulation (TNS) or by exogenous norepinephrine (NE) was investigated in perfused rat tail artery with intact endothelium. 2. NCX 4016 (25, 50 and 100 microM) dose-dependently antagoni...

journal_title：British journal of pharmacology

authors： Rossoni G,Manfredi B,Del Soldato P,Berti F

更新日期：2002-09-01 00:00:00

abstract：:1. Male, Long Evans rats were instrumented chronically with pulsed Doppler probes and intravascular catheters to allow assessment of regional haemodynamic changes during i.v. infusion of lipopolysaccharide (LPS, 150 micrograms kg-1 h-1). 2. In the presence of the AT1-receptor antagonists, losartan (10 mg kg-1 + 10 kg-...

journal_title：British journal of pharmacology

authors： Gardiner SM,Kemp PA,March JE,Bennett T

更新日期：1996-12-01 00:00:00

abstract：:The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake. ...

journal_title：British journal of pharmacology

authors： Peters JA,Malone HM,Lambert JJ

更新日期：1991-07-01 00:00:00

abstract：:1. The effects of the muscarinic agonist carbachol on phosphoinositide metabolism and its relationship to alteration of intracellular calcium were examined in SK-N-SH human neuroblastoma cells. Muscarinic receptors on these cells are coupled to phospholipase C and the myo [2-3H]-inositol phosphates resulting from rece...

journal_title：British journal of pharmacology

authors： Baird JG,Lambert DG,McBain J,Nahorski SR

更新日期：1989-12-01 00:00:00

abstract：:The effects of histamine and of H1- and H2-receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea-pigs. Histamine and H2-receptor agonists (dimaprit, impromidine) dose-dependently decrease the positive chronotropic and inotropic effects, and the seve...

journal_title：British journal of pharmacology

authors： Blandina P,Brunelleschi S,Fantozzi R,Giannella E,Mannaioni PF,Masini E

更新日期：1987-03-01 00:00:00

abstract：:1. Adenosine A(1), A(2A), and A(3) receptors (ARs) and extracellular signal-regulated kinase 1/2 (ERK1/2) play a major role in myocardium protection from ischaemic injury. In this study, we have characterized the adenosine receptor subtypes involved in ERK1/2 activation in newborn rat cardiomyocytes. 2. Adenosine (non...

journal_title：British journal of pharmacology

authors： Germack R,Dickenson JM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regul...

journal_title：British journal of pharmacology

authors： Pathania D,Kuang Y,Sechi M,Neamati N

更新日期：2015-01-01 00:00:00

abstract：:Rat vas deferens preparations became desensitized to the alpha 1-adrenoceptor antagonist thymoxamine: after 6 h in vitro, the t 1/2 value (time to attain half the occupancy of receptors occupied at equilibrium) of the response to this drug was 1.50 fold greater in control strips (strips exposed to thymoxamine at 6 h) ...

journal_title：British journal of pharmacology

authors： Onnen I

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH:A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain librar...

journal_title：British journal of pharmacology

authors： Fonfria E,Clay WC,Levy DS,Goodwin JA,Roman S,Smith GD,Condreay JP,Michel AD

更新日期：2008-02-01 00:00:00

abstract：:1 Pretreatment of dogs for 20 to 24 h before the start of experiments with reserpine (0.5 mg/kg) depleted noradrenaline from cerebral and mesenteric arteries, the diminution being greater in the latter arteries. 2 Contractile responses of helically-cut strips of cerebral and mesenteric arteries to noradrenaline were u...

journal_title：British journal of pharmacology

authors： Hayashi S,Miyazaki M,Toda N

更新日期：1980-03-01 00:00:00

abstract：:1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination of the affinit...

journal_title：British journal of pharmacology

authors： Ivorra MD,Lugnier C,Schott C,Catret M,Noguera MA,Anselmi E,D'Ocon P

更新日期：1992-06-01 00:00:00

abstract：:1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. The purpose of this study was to investigate the role of the cannabinoid and opioid systems in mediating this analgesic effect. 2 Elevated...

journal_title：British journal of pharmacology

authors： Chang L,Luo L,Palmer JA,Sutton S,Wilson SJ,Barbier AJ,Breitenbucher JG,Chaplan SR,Webb M

更新日期：2006-05-01 00:00:00

abstract：:1. Prolongation of action potentials by cooling or pharmacological treatment can restore conduction in demyelinated axons. We have assessed the ability of pyrethroids (in vitro) to modify action potential kinetics and to reverse conduction block in lesioned peripheral nerve. 2. Fast Na+ currents were isolated in mamma...

journal_title：British journal of pharmacology

authors： Lees G

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The glucagon-like peptides GLP-1 and GLP-2 are secreted from enteroendocrine L-cells following nutrient ingestion. Drugs that increase activity of the GLP-1 axis are highly successful therapies for type 2 diabetes, and boosting L-cell secretion is a potential strategy for future diabetes treatmen...

journal_title：British journal of pharmacology

authors： Parker HE,Wallis K,le Roux CW,Wong KY,Reimann F,Gribble FM

更新日期：2012-01-01 00:00:00