Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans.

abstract：:The intravenous administration of naloxone 2 min before coronary artery occlusion in anaesthetized dogs reduced the incidence and severity of cardiac arrhythmias during coronary occlusion (20 min) and reperfusion (120 min) in a dose-related manner. It also reduced the mortality. At a dose of 1 mg kg-1 (the maximum dos...

journal_title：British journal of pharmacology

authors： Huang XD,Lee AY,Wong TM,Zhan CY,Zhao YY

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Post-operative ileus (POI) is induced by intestinal inflammation. Here, we aimed to clarify the effects of 5-HT3 receptor antagonists against POI. EXPERIMENTAL APPROACH:We administered three 5-HT3 receptor antagonists, ondansetron, tropisetron and palonosetron, to a mouse model of POI induced by...

journal_title：British journal of pharmacology

authors： Maehara T,Matsumoto K,Horiguchi K,Kondo M,Iino S,Horie S,Murata T,Tsubone H,Shimada S,Ozaki H,Hori M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:P2X(7), receptors are potently inhibited by extracellular acidification. The underlying molecular basis remains unknown. This study aimed to examine the role of extracellular histidine, lysine, aspartic acid and glutamic acid residues in the functional inhibition of rat P2X(7) receptors by acidic...

journal_title：British journal of pharmacology

authors： Liu X,Ma W,Surprenant A,Jiang LH

更新日期：2009-01-01 00:00:00

abstract：:1. The effect of the nitro-derivative of aspirin, NCX4016, was assessed on ischaemic ventricular arrhythmias and myocardial infarct size in anaesthetized pigs in comparison to native aspirin. 2. Pigs were given aspirin (10 mg kg(-1); n=6), low dose NCX4016 (18.4 mg kg(-1); n=6) or high dose NCX4016 (60 mg kg(-1); n=7)...

journal_title：British journal of pharmacology

authors： Wainwright CL,Miller AM,Work LM,Del Soldato P

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sulphatides are sulphated glycosphingolipids expressed on the surface of many cell types, particularly neurones. Changes in sulphatide species or content have been associated with epilepsy and Alzheimer's disease. As the large conductance, calcium sensitive K(+) channel (BK(Ca)) are modulated by ...

journal_title：British journal of pharmacology

authors： Chi S,Qi Z

更新日期：2006-12-01 00:00:00

abstract：:1. General anaesthetics disrupt normal cell receptivity and responsiveness while sparing vital respiratory processes. Ultimate elucidation of the molecular basis of general anaesthesia presumes the identification of one or more subcellular components with appropriate sensitivity to the entire array of anaesthetics. 2....

journal_title：British journal of pharmacology

authors： LaBella FS,Chen QM,Stein D,Queen G

更新日期：1997-03-01 00:00:00

abstract：:1. The aim of the study was to investigate the mechanism of a novel effect of hypoxia on intracellular Ca(2+) signalling in rabbit cerebral arteriolar smooth muscle cells, an effect that was resistant to the L-type Ca(2+) channel antagonist methoxyverapamil (D600). 2.[Ca(2+)](i) of smooth muscle cells in intact arteri...

journal_title：British journal of pharmacology

authors： Guibert C,Flemming R,Beech DJ

更新日期：2002-02-01 00:00:00

abstract：:The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and exp...

journal_title：British journal of pharmacology

authors： Schwingshackl L,Morze J,Hoffmann G

更新日期：2020-03-01 00:00:00

abstract：:Lignocaine suppresses insulin-stimulated glucose transport into the cells and insulin-stimulated glycogenesis at doses equivalent to that used in the treatment of muscle pain disorder. We evaluated the direct effect of lignocaine on insulin receptor (IR) kinase activity. After lignocaine (40 mM, approximately equivale...

journal_title：British journal of pharmacology

authors： Hirose M,Martyn JA,Kuroda Y,Marunaka Y,Tanaka Y

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to understand why (-)-cannabidiol (CBD) and (-)-cannabidiol-dimethylheptyl (CBD-DMH) exhibit distinct pharmacology, despite near identical structures. EXPERIMENTAL APPROACH:HEK293A cells expressing either human type 1 cannabinoid (CB1 ) receptors or CB2 receptors were treated with CBD ...

journal_title：British journal of pharmacology

authors： Tham M,Yilmaz O,Alaverdashvili M,Kelly MEM,Denovan-Wright EM,Laprairie RB

更新日期：2019-05-01 00:00:00

abstract：:In vitro preparations of rabbit heart were made from which measurements of effective refractory period (ERP), atrio-Hisian (A-H) and His-Purkinje (H-P) conduction times could be obtained, analogous to electrophysiological measurements customarily carried out in vivo. Intracellular potentials also were recorded from th...

journal_title：British journal of pharmacology

authors： Millar JS,Vaughan Williams EM

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cigarette smoke is a major cause for chronic obstructive pulmonary disease (COPD). Andrographolide is an active biomolecule isolated from the plant Andrographis paniculata. Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant...

journal_title：British journal of pharmacology

authors： Guan SP,Tee W,Ng DS,Chan TK,Peh HY,Ho WE,Cheng C,Mak JC,Wong WS

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Biased GPCR ligands are able to engage with their target receptor in a manner that preferentially activates distinct downstream signalling and offers potential for next generation therapeutics. However, accurate quantification of ligand bias in vitro is complex, and current best practice is not a...

journal_title：British journal of pharmacology

authors： Winpenny D,Clark M,Cawkill D

更新日期：2016-04-01 00:00:00

abstract：:1. The effect of synthetic tachykinin selective receptor agonists was studied on the growth of cultured human skin fibroblasts (HF). 2. Human fibroblasts were grown in serum-free conditions in the presence of natural tachykinins (substance P and neurokinin A) and of three synthetic agonists, [beta-Ala4, Sar9, Met(O2)1...

journal_title：British journal of pharmacology

authors： Ziche M,Morbidelli L,Pacini M,Dolara P,Maggi CA

更新日期：1990-05-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3), a constitutively acting multi-functional serine threonine kinase is involved in diverse physiological pathways ranging from metabolism, cell cycle, gene expression, development and oncogenesis to neuroprotection. These diverse multiple functions attributed to GSK3 can be explained by...

journal_title：British journal of pharmacology

authors： Rayasam GV,Tulasi VK,Sodhi R,Davis JA,Ray A

更新日期：2009-03-01 00:00:00

abstract：:1. The NK1 tachykinin receptor agonists, septide, [Sar9,Met(O2)11]SP and [Pro9]SP produced locomotor hyperactivity (10-20 min) when injected intracerebroventricularly (i.c.v.) in the guinea-pig. The most potent in eliciting this hyperactivity was septide (from 0.63 to 5 micrograms), compared to [Sar9,Met(O2)11]SP, whi...

journal_title：British journal of pharmacology

authors： Piot O,Betschart J,Grall I,Ravard S,Garret C,Blanchard JC

更新日期：1995-11-01 00:00:00

abstract：:The distribution of beta-adrenoceptor subtypes in slide-mounted sections of guinea-pig kidney has been examined by the technique of in vitro labelling combined with autoradiography. Binding of (-)-[125I]-cyanopindolol (Cyp) to kidney sections equilibrated and dissociated slowly, was saturable and stereoselective with ...

journal_title：British journal of pharmacology

authors： Lew R,Summers RJ

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cultured pre-adipocytes accumulate and metabolize zidovudine (ZDV), but its mode of accumulation into these cells is unclear. We investigated the mode of accumulation of [(3)H]-ZDV, and the impact of changes in external pH and modulators of drug transporters on its accumulation and metabolism. E...

journal_title：British journal of pharmacology

authors： Janneh O,Owen A,Bray PG,Back DJ,Pirmohamed M

更新日期：2010-01-01 00:00:00

abstract：:1 The actions of prostaglandin F2 alpha (PGF2 alpha) and noradrenaline on contraction and 45Ca exchange have been studied in rat mesenteric arteries. 2 PGF2 alpha and noradrenaline contracted rat isolated mesenteric artery preparations to about the same extent. The PGF2 alpha-stimulated contractions, unlike those prod...

journal_title：British journal of pharmacology

authors： Godfraind T,Miller RC

更新日期：1982-01-01 00:00:00

abstract：:1. An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents.2. Radioisotope studies showed that cadmium and zinc ...

journal_title：British journal of pharmacology

authors： Schnieden H,Small RC

更新日期：1971-03-01 00:00:00

abstract：:1. 5-HT and the prostanoid TP receptor agonists, U46619 and I-BOP, constricted the human umbilical artery with pEC50 values of 7.3+/-0. 2, 6.7+/-0.1, and 7.3+/-0.2, respectively. The selective TP receptor antagonist, GR32191 (0.1 microM), shifted the concentration-effect curves to U46619 and I-BOP to the right, but ha...

journal_title：British journal of pharmacology

authors： Boersma JI,Janzen KM,Oliveira L,Crankshaw DJ

更新日期：1999-12-01 00:00:00

abstract：:1. The effect of [Na]o on the catecholamine release evoked by K in ouabain pretreated, isolated adrenal glands of the cat, was investigated. 2. Reduction of [Na]o to 70, 50 and 25 mM, with sucrose as a substitute, did not modify the spontaneous catecholamine release but progressively increased the K (17.7 mM)-evoked s...

journal_title：British journal of pharmacology

authors： Abajo FJ,Castro MA,Sánchez-García P

更新日期：1989-10-01 00:00:00

abstract：:1. The possible roles of endothelial and smooth muscle cell hyperpolarization and nitric oxide (NO) in endothelium-dependent relaxation were examined in isolated rings of pig right coronary artery. 2. The effects of hyperpolarization were prevented with high K+ (30-125 mM), isotonic Krebs solutions. Functional antagon...

journal_title：British journal of pharmacology

authors： Kilpatrick EV,Cocks TM

更新日期：1994-06-01 00:00:00

abstract：:1. The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of action of these GABA-B receptor agonists to inhibit the cough reflex. 2. Single intracerebroventricular (i.c.v.) cannulas wer...

journal_title：British journal of pharmacology

authors： Bolser DC,DeGennaro FC,O'Reilly S,Chapman RW,Kreutner W,Egan RW,Hey JA

更新日期：1994-12-01 00:00:00

abstract：:1. Acute moderate hypoxia modifies the catalytic activity and expression of certain isoenzymes of hepatic cytochrome P450 (P450). The aim of this study was to document whether hypoxia affects hepatic P450 directly or through the release of serum mediators. 2. Rabbits were subjected to a FiO(2) of 8% for 48 h, sacrific...

journal_title：British journal of pharmacology

authors： Fradette C,Bleau AM,Pichette V,Chauret N,Du Souich P

更新日期：2002-11-01 00:00:00

abstract：:The effects of injection of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and N-ethyl-3,4-methylenedioxyamphetamine (MDEA) (all 20 mg kg(-1)) on blood pressure, heart rate, core body temperature and locomotor activity in conscious rats were investigated using radiotelemetry. MDMA and MD...

journal_title：British journal of pharmacology

authors： Bexis S,Docherty JR

更新日期：2006-04-01 00:00:00

abstract：:1. Both in mammalian tissues and in transfected cells, only low levels of alpha1D-adrenoceptors are detected in radioligand binding studies. It has been implicated that the comparatively long N-terminal tail of the alpha1D-adrenoceptor is responsible for the inefficient surface expression of the receptor. 2. In the pr...

journal_title：British journal of pharmacology

authors： Petrovska R,Kapa I,Klovins J,Schiöth HB,Uhlén S

更新日期：2005-03-01 00:00:00

abstract：:1. LP-805, 8-tert-butyl-6,7-dihydropyrrolo-[3,2-e]-5-methylpyrazolo- [1,5a]-pyrimidine-3-carbonitrile, is a newly synthesized potent vasodilator. To investigate the cellular mechanisms of vasorelaxation induced by LP-805, we simultaneously determined the effects of LP-805 on cytosolic Ca2+ concentrations ([Ca2+]i) and...

journal_title：British journal of pharmacology

authors： Ushio-Fukai M,Hirano K,Kanaide H

更新日期：1994-12-01 00:00:00

abstract：:1. The intravenous infusion of I.C.I. 50172 in doses up to 20 mg reduced, although not significantly, the increase in heart rate produced by the infusion of isoprenaline in healthy volunteers; the response to adrenaline was significantly reduced. The infusion of 1 mg propranolol abolished these responses2. After the p...

journal_title：British journal of pharmacology

authors： Brick I,Hutchison KJ,McDevitt DG,Roddie IC,Shanks RG

更新日期：1968-09-01 00:00:00

abstract：:The interaction of a new nonribose ligand (LUF5831) with the human adenosine A1 receptor was investigated in the present study. Radioligand binding experiments were performed in the absence and presence of diverse allosteric modulators on both wild-type (wt) and mutant (T277A) adenosine A1 receptors. Thermodynamic dat...

journal_title：British journal of pharmacology

authors： Heitman LH,Mulder-Krieger T,Spanjersberg RF,von Frijtag Drabbe Künzel JK,Dalpiaz A,IJzerman AP

更新日期：2006-03-01 00:00:00