Glycogen synthase kinase 3: more than a namesake.

abstract：BACKGROUND AND PURPOSE:As a hallmark of glioblastoma multiforme (GBM), CD44 plays a crucial role in promoting glioblastoma stem cell (GSC) stemness phenotypes and multiple drug resistance. The therapeutic potential of CD44 has been validated by the clinical successes of several CD44 inhibitors, including antibodies and...

journal_title：British journal of pharmacology

authors： Wang C,Wang Z,Chen C,Fu X,Wang J,Fei X,Yan X,Xu R

更新日期：2020-07-01 00:00:00

abstract：:1. Vasospasm of arterial conduits used for coronary artery surgery is an important cause of graft failure and is likely to result partly from raised levels of vasoconstrictor substances such as thromboxane A(2) and endothelin-1. Our aim was to find pharmacological agents that could prevent agonist-induced vasospasm. 2...

journal_title：British journal of pharmacology

authors： Batchelor TJ,Sadaba JR,Ishola A,Pacaud P,Munsch CM,Beech DJ

更新日期：2001-01-01 00:00:00

abstract：:1. This study analyses the receptors mediating the effects of bradykinin (BK) and analogues on neurogenic twitch contractions of the mouse isolated vas deferens evoked, in the presence of captopril (3 microM), by electrical field stimulation with trains of 4 rectangular 0.5 ms pulses of supramaximal strength, delivere...

journal_title：British journal of pharmacology

authors： Maas J,Rae GA,Huidobro-Toro JP,Calixto JB

更新日期：1995-04-01 00:00:00

abstract：:1. The effects of alpha 2-adrenoceptor and kappa-opiate receptor activation on 45Ca accumulation into rat cortical synaptosomes were examined. 2. Clonidine (1 microM) and U50488H (1 microM) significantly reduced 45Ca accumulation under both resting (5 mM K+) and depolarizing (15-30 mM K+) conditions. 3. The inhibitory...

journal_title：British journal of pharmacology

authors： Xiang JZ,Brammer MJ,Campbell IC

更新日期：1990-09-01 00:00:00

abstract：:1. Behavioural activity (delayed differentiation and spatial delayed alternation) and pharmacokinetics of diazepam and its metabolites, N-desmethyldiazepam (nordiazepam), 3-hydroxydiazepam (temazepam) and 3-hydroxy-N-desmethyldiazepam (oxazepam), and of dipotassium clorazepate (clorazepate), were studied in the monkey...

journal_title：British journal of pharmacology

authors： Curry SH,Whelpton R,Nicholson AN,Wright CM

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypoxia in tumours is known to cause resistance to conventional chemotherapeutic drugs. In contrast, little is known about the effects of hypoxia on targeted anti-cancer drugs. This study evaluated the effect of hypoxia on a series of clinically approved tyrosine kinase inhibitors (TKIs). EXPERI...

journal_title：British journal of pharmacology

authors： Ahmadi M,Ahmadihosseini Z,Allison SJ,Begum S,Rockley K,Sadiq M,Chintamaneni S,Lokwani R,Hughes N,Phillips RM

更新日期：2014-01-01 00:00:00

abstract：:1. In rats, recovery of sensory-motor function following a crush lesion of the sciatic or tibial nerve was monitored by measuring foot reflex withdrawal from a local noxious stimulation of the foot sole. 2. Putative neurotrophic compounds were tested on this functional recovery model: melanocortins (peptides derived f...

journal_title：British journal of pharmacology

authors： Van der Zee CE,Brakkee JH,Gispen WH

更新日期：1991-05-01 00:00:00

abstract：:Two splice isoforms of rabbit alpha(1a)-adrenergic receptor (AR), (named alpha(1a)-OCU.2-AR and alpha(1a)-OCU.3-AR) have been isolated from the liver cDNA library in addition to the previously reported isoform (alpha(1a)-OCU.1-AR). Although they have the identical splice position with human alpha(1a)-AR isoforms, the ...

journal_title：British journal of pharmacology

authors： Suzuki F,Taniguchi T,Takauji R,Murata S,Muramatsu I

更新日期：2000-04-01 00:00:00

abstract：:1. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), gepirone, buspirone and ipsapirone dose-dependently antagonized the head-shakes induced by 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane hydrochloride (DOI) (1.0 mg kg-1) in mice, when these agents were given i.p. 10 min beforehand. 2. para-Chlorophenylalanine (...

journal_title：British journal of pharmacology

authors： Dursun SM,Handley SL

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The thiourea derivative KB-R7943, originally developed as inhibitor of the plasma membrane Na(+)/Ca(2+) exchanger, has been shown to protect against myocardial ischemia-reperfusion injury. We have studied here its effects on mitochondrial Ca(2+) fluxes. EXPERIMENTAL APPROACH:[Ca(2+)] in cytosol,...

journal_title：British journal of pharmacology

authors： Santo-Domingo J,Vay L,Hernández-Sanmiguel E,Lobatón CD,Moreno A,Montero M,Alvarez J

更新日期：2007-07-01 00:00:00

abstract：:1. Two-electrode voltage clamp was used to study the effects of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and guanosine 3':5'-cyclic monophosphate (cyclic GMP) on voltage-dependent ion channels in salivary gland cells of the leech, Haementeria ghilianii. 2. Intracellular cyclic AMP specifically blocked delayed...

journal_title：British journal of pharmacology

authors： Everill B,Berry MS

更新日期：1995-09-01 00:00:00

abstract：:1. Intrathecal (i.t.) injection of nociceptin at small doses (fmol order) elicited a behavioural response consisting of scratching, biting and licking in conscious mice. Here we have examined the involvement of substance P-containing neurons by using i.t. injection of tachykinin neurokinin (NK)1 receptor antagonists a...

journal_title：British journal of pharmacology

authors： Sakurada T,Katsuyama S,Sakurada S,Inoue M,Tan-No K,Kisara K,Sakurada C,Ueda H,Sasaki J

更新日期：1999-08-01 00:00:00

abstract：:In circular smooth muscle cells of the guinea-pig stomach (antrum), diltiazem (10(-6)-10(-5)M) blocked the overshooting spike potential generated either spontaneously or by electrical stimulation in the presence of 2 mM tetraethylammonium chloride, but did not block the slow wave and the abortive spike potential. The ...

journal_title：British journal of pharmacology

authors： Ishikawa S,Komori K,Nagao T,Suzuki H

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increases in intracellular cyclic AMP (cAMP) augment the release/secretion of glucagon-like peptide-1 (GLP-1). As cAMP is hydrolysed by cAMP phosphodiesterases (PDEs), we determined the role of PDEs and particularly PDE4 in regulating GLP-1 release. EXPERIMENTAL APPROACH:GLP-1 release, PDE expre...

journal_title：British journal of pharmacology

authors： Ong WK,Gribble FM,Reimann F,Lynch MJ,Houslay MD,Baillie GS,Furman BL,Pyne NJ

更新日期：2009-06-01 00:00:00

abstract：:1. The ability of PD 128907 to activate dopamine receptors in the ventral tegmental area, substantia nigra pars compacta, and striatum was investigated by use of in vitro electrophysiological recording and fast cyclic voltammetry. The affinity of a novel D2 selective antagonist L-741,626 for receptors activated by thi...

journal_title：British journal of pharmacology

authors： Bowery BJ,Razzaque Z,Emms F,Patel S,Freedman S,Bristow L,Kulagowski J,Seabrook GR

更新日期：1996-12-01 00:00:00

abstract：:1. The systemic and regional haemodynamic effects of the potassium channel activator EMD 52692 or its solvent were investigated after intravenous and after intracoronary administration in anaesthetized pigs. 2. Consecutive intravenous 10 min infusions of EMD 52692 (0.15, 0.30, 0.60, 1.20 micrograms kg-1 min-1; n = 7) ...

journal_title：British journal of pharmacology

authors： Sassen LM,Duncker DJ,Gho BC,Diekmann HW,Verdouw PD

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Allosteric modulators of ionotropic receptors and GPCRs might constitute valuable therapeutic tools for intervention in several diseases, including Parkinson's disease (PD). However, the possibility that some of these compounds could alter neurotransmission in health and disease has not been thor...

journal_title：British journal of pharmacology

authors： Zhang X,Feng ZJ,Chergui K

更新日期：2014-08-01 00:00:00

abstract：:1. The effects of pregnancy on mesenteric arterial function were examined in constantly perfused (5 ml min-1) mesenteric arterial beds isolated from 21-day pregnant rats. The function of sympathetic and sensory-motor perivascular nerves, endothelium and smooth muscle was examined. The role of nitric oxide and prostagl...

journal_title：British journal of pharmacology

authors： Ralevic V,Burnstock G

更新日期：1996-04-01 00:00:00

abstract：:1. The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2. NPY inhibited or suppressed the cholinergic contractile response...

journal_title：British journal of pharmacology

authors： Takaki M,Nakayama S

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early soluble epoxide hydrolase inhibitors (sEHIs) such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) are effective anti-hypertensive and anti-inflammatory agents in various animal models. However, their poor metabolic stability and limited water solubility make them difficult to use pha...

journal_title：British journal of pharmacology

authors： Liu JY,Tsai HJ,Hwang SH,Jones PD,Morisseau C,Hammock BD

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Asthenozoospermia is a leading cause of male infertility, but development of pharmacological agents to improve sperm motility is hindered by the lack of effective screening platforms and knowledge of suitable molecular targets. We have demonstrated that a high-throughput screening (HTS) strategy ...

journal_title：British journal of pharmacology

authors： McBrinn RC,Fraser J,Hope AG,Gray DW,Barratt CLR,Martins da Silva SJ,Brown SG

更新日期：2019-12-01 00:00:00

abstract：:Cellular electrophysiological effects of membrane lipid peroxidation by t-butyl hydroperoxide (TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1-5 min with 300 microM TBH caused an initial increase and subsequent decrease in the spontaneous firing frequency of the SA node. Voltage clamp experimen...

journal_title：British journal of pharmacology

authors： Sato N,Nishimura M,Tanaka H,Homma N,Watanabe Y

更新日期：1989-11-01 00:00:00

abstract：:(1) The effects on the whole-cell carbachol-induced muscarinic cationic current (mIcat) of antibodies against the alpha-subunits of various G proteins, as well as the effect of a Gbetagamma subunit, were studied in single guinea-pig ileal smooth muscle cells voltage-clamped at -50 mV. Ionized intracellular calcium con...

journal_title：British journal of pharmacology

authors： Yan HD,Okamoto H,Unno T,Tsytsyura YD,Prestwich SA,Komori S,Zholos AV,Bolton TB

更新日期：2003-06-01 00:00:00

abstract：:1 The actions of prostaglandin F2 alpha (PGF2 alpha) and noradrenaline on contraction and 45Ca exchange have been studied in rat mesenteric arteries. 2 PGF2 alpha and noradrenaline contracted rat isolated mesenteric artery preparations to about the same extent. The PGF2 alpha-stimulated contractions, unlike those prod...

journal_title：British journal of pharmacology

authors： Godfraind T,Miller RC

更新日期：1982-01-01 00:00:00

abstract：:Chronic itch poses major health care and economic burdens worldwide. In 2013, B-type natriuretic peptide (BNP) was identified as an itch-selective neuropeptide and shown to be both necessary and sufficient to produce itch behaviour in mice. Since then, mechanistic studies of itch have increased, not only at central le...

journal_title：British journal of pharmacology

authors： Meng J,Chen W,Wang J

更新日期：2020-03-01 00:00:00

abstract：:1. The serine/threonine protein phosphatase (PP) inhibitors, okadaic acid and calyculin, attenuated the IgE-mediated release of histamine from human lung mast cells (HLMC) and basophils in a dose-dependent manner whereas an alternative PP inhibitor, microcystin, was ineffective. Calyculin was more potent than okadaic ...

journal_title：British journal of pharmacology

authors： Peirce MJ,Munday MR,Peachell PT

更新日期：1998-11-01 00:00:00

abstract：:1. Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present pape...

journal_title：British journal of pharmacology

authors： Carlini EA,Lindsey CJ,Tufik S

更新日期：1977-11-01 00:00:00

abstract：:1 The effects of general anaesthetics on the responses of neurones to iontophoretically applied L-glutamate have been examined in slices of the guinea-pig olfactory cortex in vitro. 2 Concentrations of pentobarbitone, ether, methoxyflurance, trichloroethylene and alphaxalone that are known to depress synaptic transmis...

journal_title：British journal of pharmacology

authors： Richards CD,Smaje JC

更新日期：1976-11-01 00:00:00

abstract：:1 The concept that presynaptic receptors regulate noradrenergic transmitter release via a system of inhibitory receptors mediating negative feedback relies on a supposed association between increases in stimulation-induced efflux of [3H]-noradrenaline by antagonists and blockade by them of the inhibitory effects of ex...

journal_title：British journal of pharmacology

authors： Kalsner S

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Picomolar concentrations of the beta3-adrenoceptor agonist BRL37344 stimulate 2-deoxyglucose uptake in soleus muscle via undefined receptors. Higher concentrations alter uptake, apparently via beta2-adrenoceptors. Effects of BRL37344 and beta2-adrenoceptor agonists are compared. EXPERIMENTAL APP...

journal_title：British journal of pharmacology

authors： Ngala RA,O'Dowd J,Wang SJ,Agarwal A,Stocker C,Cawthorne MA,Arch JR

更新日期：2008-10-01 00:00:00