Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.


:The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA. Ethanol extract obtained from Kaempferia parviflora rhizome significantly increased the accumulation of rhodamine 123 and daunorubicin, P-gp substrates, in LLC-GA5-COL150 cells, but not in LLC-PK1 cells. The aqueous extract also increased the accumulation in LLC-GA5-COL150 cells with lower potency than the ethanol extract. The effects of flavone derivatives isolated from the rhizome of Kaempferia parviflora on P-gp function were examined. Among six flavones tested, 3,5,7,3',4'-pentamethoxyflavone most potently increased the accumulation of rhodamine 123 and daunorubicin in LLC-GA5-COL150 cells in a concentration-dependent manner. In addition, 5,7-dimethoxyflavone to lesser degree increased rhodamine 123 accumulation in LLC-GA5-COL150 cells. In contrast, the other four flavone derivatives had no significant effect on the accumulation of rhodamine 123 in LLC-GA5-COL150 cells in a concentration range tested. These results indicate that extracts and flavone derivatives from the rhizome of Kaempferia parviflora can inhibit P-gp function, which may be useful for overcoming P-gp-mediated multidrug resistance and improving the oral bioavailability of anticancer agents.


J Pharm Sci


Patanasethanont D,Nagai J,Yumoto R,Murakami T,Sutthanut K,Sripanidkulchai BO,Yenjai C,Takano M




Has Abstract


2007-01-01 00:00:00














  • Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin.

    abstract::The effect of chemical penetration enhancers (e.g., fatty acids) in combination with iontophoresis was examined on the in vitro permeability of luteinizing hormone releasing hormone (LHRH) through porcine skin. Porcine epidermis was pretreated with either ethanol (EtOH) or 10% fatty acid/EtOH. The permeability coeffic...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bhatia KS,Singh J

    更新日期:1998-04-01 00:00:00

  • Scale Up of Pan Coating Process Using Quality by Design Principles.

    abstract::Scale up of pan coating process is of high importance to the pharmaceutical and food industry. The number of process variables and their interdependence in a pan coating process can make it a rather complex scale-up problem. This review discusses breaking down the coating process variables into three main categories: ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Agrawal AM,Pandey P

    更新日期:2015-11-01 00:00:00

  • The relationship between "BET" and "free volume"-derived parameters for water vapor absorption into amorphous solids.

    abstract::Water vapor absorption isotherms for amorphous solids with the same chemical composition but differing in molecular weight (i.e., PVP-90, PVP-30, and PVP-12), and for glucose, trehalose, and two molecular weight grades of dextran were obtained at 30 degrees C and analyzed using the Brunauer-Emmett-Teller (BET) equatio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zhang J,Zografi G

    更新日期:2000-08-01 00:00:00

  • High-performance liquid chromatographic determination of propranolol and 4-hydroxypropranolol in plasma.

    abstract::A high-performance liquid chromatographic method for the simultaneous determination of propranolol and 4-hydroxypropranolol in plasma is presented. The method involves plasma extraction at basic pH with ethyl column, and fluorescence detection. The within-run a reversed-phase column coefficient of variation were 3.0-7...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rosseel MT,Bogaert MG

    更新日期:1981-06-01 00:00:00

  • Determination of propylene carbonate in pharmaceutical formulations using liquid chromatography.

    abstract::A stability-indicating reversed-phase high-performance liquid chromatographic method using a refractive index detector is described for the determination of propylene carbonate in pharmaceutical formulations. Good precision and accuracy of the method was demonstrated using an aqueous formulation. This method is also a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cheng H,Gadde RR

    更新日期:1985-06-01 00:00:00

  • Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research.

    abstract::The tissue:plasma partition coefficients (Kp ) are good indicators of the extent of tissue distribution. Therefore, advanced tissue composition-based models were used to predict the Kp values of drugs under in vivo conditions on the basis of in vitro and physiological input data. These models, however, focus on animal...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Poulin P

    更新日期:2015-06-01 00:00:00

  • Preparation and Characterization of Ascosome Vesicles Loaded with Khellin.

    abstract::Ascorbic acid has a unique role in the prevention and treatment of a large number of chronic diseases, including skin disorders but it can hardly penetrate the skin due to its solubility in water and its high instability. This study explored the formation of phosphatidylcholine-based vesicles upon addition of ascorbyl...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Risaliti L,Ambrosi M,Calamante M,Bergonzi MC,Lo Nostro P,Bilia AR

    更新日期:2020-10-01 00:00:00

  • Thermodynamic evaluation of activated charcoal as a poison antidote by high-performance liquid chromatography. II: In vitro method for the evaluation of activated charcoal as a poison antidote.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kleeman WP,Bailey LC

    更新日期:1988-06-01 00:00:00

  • Toward Understanding Drug Release From Biodegradable Polymer Microspheres of Different Erosion Kinetics Modes.

    abstract::Two generalized modes of erosion kinetics, that is, the power law mode and root type mode, respectively, were found to be able to better describe the reported weight loss data compared to the existing linear mode, for commonly used surface-eroding polymer microspheres. Based on the newly identified modes, a set of dru...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: You S,Yang Z,Wang CH

    更新日期:2016-06-01 00:00:00

  • Interactions of cephalosporins and penicillins with nonpolar octadecylsilyl stationary phase.

    abstract::The capacity factors of several penicillins and cephalosporins, as well as those of 7-aminocephalosporanic acid, 6-aminopenicillanic acid, and 7-aminodeacetoxycephalosporanic acid, were determined at pH 2.5-7.5 with different methanol concentrations in the mobile phase. The influence of ionic strength on activity fact...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Salto F,Prieto JG,Alemany MT

    更新日期:1980-05-01 00:00:00

  • Pilocarpine prodrugs. II. Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters.

    abstract::Various novel diesters of pilocarpic acid were synthesized and evaluated as prodrug forms for pilocarpine with the aim of improving the ocular delivery characteristics of the drug. The pilocarpic acid monoesters previously studied cyclized spontaneously to pilocarpine in aqueous solution and although they showed enhan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bundgaard H,Falch E,Larsen C,Mosher GL,Mikkelson TJ

    更新日期:1986-08-01 00:00:00

  • Progestin permeation through polymer membrane V: Progesterone release from monolithic hydrogel devices.

    abstract::Progesterone release from monolithic devices prepared from various copolymers of poly(hydroxyethyl methacrylate) and poly(methoxyethoxyethyl methacrylate) or poly(methoxyethyl methacrylate) was examined. In general, plots of the fraction of drug released versus (time)1/2 were linear during the early stages of drug rel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Song SZ,Cardinal JR,Kim SH,Kim SW

    更新日期:1981-02-01 00:00:00

  • Pharmacokinetics and tissue distribution after intravenous administration of a single dose of amphotericin B cochleates, a new lipid-based delivery system.

    abstract::Model independent pharmacokinetic analysis of intravenous (iv) amphotericin B cochleates (CAMB), a new lipid-based drug delivery system, in mice (0.625 mg/kg) shows a two-phase disposition profile in blood [area under the curve of concentration versus time from time zero to infinity (AUC(0-infinity)) = 1.01 microg. h/...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Segarra I,Movshin DA,Zarif L

    更新日期:2002-08-01 00:00:00

  • Synthesis of d-pilocarpine-N-14CH3.

    abstract::The total synthesis of d-pilocarpine specifically labeled as N-14CH3 is reported. dl-Homopilopic acid was prepared as a key intermediate and resolved into the d-enantiomer via the alpha-methylbenzylamine salt. The penultimate intermediate, 2-mercaptopilocarpine, was desulfurized by oxidation with dilute hydrogen perox...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: DeGraw JI,Engstrom JS,Willis E

    更新日期:1975-10-01 00:00:00

  • The use of N,N-diethyl-m-toluamide to enhance dermal and transdermal delivery of drugs.

    abstract::A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Windheuser JJ,Haslam JL,Caldwell L,Shaffer RD

    更新日期:1982-11-01 00:00:00

  • Enhanced potency of human calcitonin when fibrillation is avoided.

    abstract::The peptide hormone calcitonin (CT) is a potent drug for the therapy of different bone diseases. Salmon CT (sCT) is reported to be more active than human CT (hCT). Human CT, but not sCT, has a strong tendency to aggregate and fibrillate in aqueous solutions. Recent investigations of the fibrillation mechanisms contrib...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cudd A,Arvinte T,Das RE,Chinni C,MacIntyre I

    更新日期:1995-06-01 00:00:00

  • Bioavailability of 17 ampicillin products.

    abstract::The bioavailability of single lots of 250-mg ampicillin capsules, available from 17 distributors and/or manufactures, was determined. Each product was evaluated in terms of the serum ampicillin levels achieved at 1, 2, 3, 4, 6, and 8 hr postadministration, the peak serum levels, the time of peak serum level, and the a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Whyatt PL,Slywka GW,Melikian AP,Meyer MC

    更新日期:1976-05-01 00:00:00

  • Collagen/PLGA microparticle composites for local controlled delivery of gentamicin.

    abstract::To preserve the positive effect of collagen on tissue regeneration and to locally deliver low molecular weight compounds for an extended time period, a composite for parenteral application was devised based on a collagen sponge with gentamicin-loaded PLGA microparticles incorporated. Antibiotic liberation from the par...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schlapp M,Friess W

    更新日期:2003-11-01 00:00:00

  • IgG1 adsorption to siliconized glass vials-influence of pH, ionic strength, and nonionic surfactants.

    abstract::In this study, the adsorption of an IgG1 antibody to siliconized vials was investigated with focus on the formulation parameters pH, ionic strength, and nonionic surfactants. Electrophoretic mobility measurements were performed to investigate the charge characteristics of protein and siliconized glass particles at dif...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Höger K,Mathes J,Frieß W

    更新日期:2015-01-01 00:00:00

  • Concomitant adsorption and stability of some anthracycline antibiotics.

    abstract::Using liquid scintillation counting and liquid chromatographic techniques, it has been demonstrated that the anthracycline antibiotics, doxorubicin hydrochloride, N-trifluoroacetyladriamycin-14-valerate, and N-trifluoroacetyladriamycin-14-octanoate, can be strongly absorbed to the walls of containers, depending on the...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tomlinson E,Malspeis L

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  • Monitoring the purity of pharmaceutical heparin preparations by high-field 1H-nuclear magnetic resonance spectroscopy.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Neville GA,Mori F,Holme KR,Perlin AS

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  • Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gui Z,Wu X,Wang S,Cao Y,Wan J,Shan Q,Yang Z,Zhang J,Gui S

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ding AG,Schwendeman SP

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  • Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In Vitro Structural Features and Release Properties.

    abstract::Alginate-based polyelectrolyte complexes (PECs) and hydrogel were engineered as platforms for local bevacizumab (BVZ) therapy. This study provides deep comprehension on the microstructures of such systems, and their correlation with drug-release patterns. PECs and hydrogel were characterized using Fourier transform in...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ferreira NN,Caetano BL,Boni FI,Sousa F,Magnani M,Sarmento B,Ferreira Cury BS,Daflon Gremião MP

    更新日期:2019-04-01 00:00:00

  • Hypolipidemic activity of 3-N-(1',8'-Naphthalimido)propionic acid in rodents.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hall IH,Chapman JM Jr,Voorstad PJ,Cocolas GH

    更新日期:1984-07-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pedersen PV,Brown KF

    更新日期:1976-10-01 00:00:00

  • Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity.

    abstract::Gold nanoparticles through nucleation of Au clusters have been extensively studied. However, due to low potency, prolonged tissue retention, and irreversible accumulation, the safety considerations have limited their therapeutic and diagnostic applications. Novel gold nanostructures with retained physical properties a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gao Y,Mu Q,Zhu L,Li Z,Ho RJY

    更新日期:2020-05-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zheng Y,Haworth IS,Zuo Z,Chow MS,Chow AH

    更新日期:2005-05-01 00:00:00

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    abstract::Although insulin receptor is expressed at the human blood-brain barrier (BBB), the physiological and pathologic roles of insulin signaling in biologic responses at the BBB remain unclear. Here, we investigate insulin signaling at the human BBB using human cerebral microvascular endothelial cell line (hCMEC/D3) as a we...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ito S,Yanai M,Yamaguchi S,Couraud PO,Ohtsuki S

    更新日期:2017-09-01 00:00:00

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    abstract::Deflocculated suspensions of coarse powders tend to cake as the individual particles settle out and form compact, cohesive sediments. Limited flocculation results in looser sediments because the settled-out flocs incorporate large amounts of the liquid suspending medium. Controlled flocculation of bismuth subnitrate s...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schott H

    更新日期:1976-06-01 00:00:00