High dose of amiodarone in a short-term period reduces the incidence of postoperative atrial fibrillation and atrial flutter.

Abstract:

OBJECTIVE:To investigate whether oral amiodarone administered before surgery for a short period in high dose would reduce the incidence of postoperative atrial fibrillation or atrial flutter and reduces the length of hospital stay. METHODS:In the double-blind, randomized study, 93 patients were given either oral amiodarone (46 patients) or placebo (47 patients). Therapy consisted of 600 mg of amiodarone three times a day, started at minimum 30 hours and at maximum 56 hours before surgery. RESULTS:Postoperative atrial fibrillation or atrial flutter occurred in 8 of 46 patients in the amiodarone group (17.4%) and 19 of the 47 patients in the placebo group (40.4%) (p=0.027). The mean dose of amiodarone was 2.8 g. Patients in the amiodarone group were hospitalized for 8.9+/-3.1 days and patients in the placebo group were hospitalized for 11.4+/-8.7 days (p=0.07). The hospital length were significantly prolonged in patients who developed atrial arrhythmias after surgery, despite the treatment received.(p<0.001). CONCLUSION:This new alternative way of using amiodarone in high dose and in a short-term period before surgery reduce the incidence of postoperative atrial fibrillation or atrial flutter in coronary artery bypass graft surgery.

journal_name

Arq Bras Cardiol

authors

Alcalde RV,Guaragna JC,Bodanese LC,Castro I,Sussenbach E,Noer R,Goldani MA,Feier F,Petracco JB

doi

10.1590/s0066-782x2006001600002

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

236-40

issue

3

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2006001600002

journal_volume

87

pub_type

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