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Hepatic uptake of cadmium and its biliary release as affected by dithioerythritol and glutathione.

Abstract：

:Net cadmium uptake in the isolated perfused rat liver was half-maximal at 5 microM, and the maximal rate of uptake was 22 nmoles/min per gram liver wet weight. Uptake was augmented when a permeable thiol, dithioerythritol, was infused, whereas it was restricted when glutathione as a nonpermeable thiol or also when bovine serum albumin were infused. The ratio of extra cadmium taken up versus dithioerythritol added was 1:2. Uptake of cadmium was insensitive to anoxia or to the infusion of cyanide. Biliary cadmium release in the perfused liver was not augmented by dithioerythritol but was rather suppressed, whereas bile flow or the release of added 3H-taurocholate were unaffected.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Graf P,Sies H

doi

10.1016/0006-2952(84)90320-4

subject

Has Abstract

pub_date

1984-02-15 00:00:00

pages

639-43

issue

4

eissn

0006-2952

issn

1873-2968

pii

0006-2952(84)90320-4

journal_volume

33

pub_type

杂志文章

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