Abstract:
:Comparison has been made of the effects on brain dopamine function of chronic administration of haloperidol or clozapine to rats for up to 12 months. In rats treated for 1-12 months with haloperidol (1.4-1.6 mg/kg/day), purposeless chewing jaw movements emerged. These movements were only observed after 12 months' treatment with clozapine (24-27 mg/kg/day). Apomorphine-induced (0.125-0.25 mg/kg) stereotyped behaviour was inhibited during 12 months treatment with haloperidol. Clozapine treatment was without effect. After 12 months, stereotypy induced by higher doses of apomorphine (0.5-1.0 mg/kg) was enhanced in haloperidol, but not clozapine, treated rats. Bmax for striatal 3H-spiperone binding was elevated throughout 12 months of haloperidol administration, but was not altered by clozapine treatment. Bmax for striatal 3H-NPA binding was only elevated after 12 months of haloperidol treatment; clozapine treatment was without effect. Bmax for 3H-piflutixol binding was not altered by haloperidol treatment, but was increased after 9 and 12 months of clozapine treatment. Dopamine (50 microM)-stimulated adenylate cyclase activity was inhibited after 1 month's haloperidol treatment but normal thereafter. Adenylate cyclase activity was not altered by chronic clozapine treatment. Striatal acetylcholine content was increased after 3 and 12 months of haloperidol or clozapine intake. These findings indicate that the chronic administration of the atypical neuroleptic clozapine does not produce changes in brain dopamine function which mirror those of the typical neuroleptic haloperidol. In particular, chronic administration of clozapine, unlike haloperidol, does not appear to induce striatal D-2 receptor supersensitivity. Unexpectedly, clozapine treatment, unlike haloperidol, altered D-1 receptor function.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Rupniak NM,Hall MD,Mann S,Fleminger S,Kilpatrick G,Jenner P,Marsden CDdoi
10.1016/0006-2952(85)90577-5subject
Has Abstractpub_date
1985-08-01 00:00:00pages
2755-63issue
15eissn
0006-2952issn
1873-2968pii
0006-2952(85)90577-5journal_volume
34pub_type
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journal_title:Biochemical pharmacology
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pub_type: 杂志文章
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更新日期:1994-11-29 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-05-15 00:00:00
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更新日期:2016-12-15 00:00:00
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pub_type: 杂志文章
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更新日期:1995-11-09 00:00:00