Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries.

abstract：:The development of neuroprotective agents is necessary for the treatment of neurodegenerative diseases. Here, we report PQA-11, a prenylated quinolinecarboxylic acid (PQA) derivative, as a potent neuroprotectant. PQA-11 inhibits glutamate-induced cell death and caspase-3 activation in hippocampal cultures, as well as ...

journal_title：Biochemical pharmacology

authors： Ogura M,Kikuchi H,Shakespear N,Suzuki T,Yamaki J,Homma MK,Oshima Y,Homma Y

更新日期：2019-04-01 00:00:00

abstract：:When INH was administered orally or intraperitoneally to pregnant female mice, the concentrations of acetyl INH and acetyl hydrazines did not vary significantly in circulating blood and in amniotic fluid. However, the concentration of INH in the amniotic fluid was significantly higher than that observed in the serum. ...

journal_title：Biochemical pharmacology

authors： Menon MM,Bhide SV

更新日期：1983-02-15 00:00:00

abstract：:3'-Azido-2',3'-dideoxy-5-iodouridine (AzIdUrd) and 3'-azido-2',3'-dideoxy-5-bromouridine (AzBdUrd), previously shown to be potent and selective inhibitors of human immunodeficiency virus replication in vitro were minimally toxic to the uninfected human lymphoid cell line H9 (IC50 = 197 and 590 microM, respectively). B...

journal_title：Biochemical pharmacology

authors： August EM,Qian HY,Birks EM,Thombre UA,Lin TS,Prusoff WH

更新日期：1993-01-07 00:00:00

abstract：:The spectrum of cytotoxicity of menadione (MD) was examined in a panel of human cancer cell lines. MD was equipotent against multidrug-resistant and parental leukemia cell lines with IC50 values of 13.5 +/- 3.6 and 18 +/- 2.4 microM respectively. A cervical carcinoma cell line resistant to the antimetabolite, methotre...

journal_title：Biochemical pharmacology

authors： Nutter LM,Cheng AL,Hung HL,Hsieh RK,Ngo EO,Liu TW

更新日期：1991-05-01 00:00:00

abstract：:New bisoxynaphthalimidopolyamines (BNIPOPut, BNIPOSpd and BNIPOSpm) were synthesized. Their cytotoxic properties were evaluated against breast cancer MCF 7 cells and compared with bisnaphthalimidopolyamines BNIPSpd and BNIPSpm. Among the bisoxynaphthalimido polyamines, BNIPOSpm and BNIPOSpd exhibited cytotoxic activit...

journal_title：Biochemical pharmacology

authors： Dance AM,Ralton L,Fuller Z,Milne L,Duthie S,Bestwick CS,Lin PK

更新日期：2005-01-01 00:00:00

abstract：:The peroxisome proliferator activated receptor-γ (PPAR-γ) is involved in the pathogenesis of diabetic retinopathy. Diabetic retinopathy is a preventable microvascular diabetic complication that damages human retinal pigment epithelial cells. Taurine is abundant in the fruit of Lycium barbarum (Goji Berry), and is repo...

journal_title：Biochemical pharmacology

authors： Song MK,Salam NK,Roufogalis BD,Huang TH

更新日期：2011-11-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) involves infiltration of leucocytes, pulmonary injury, fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor (TGF)-beta1 have been suggested to play a major role in the pathology and the myofibroblasts are derived from both lung epithelial cells...

journal_title：Biochemical pharmacology

authors： Tanaka K,Tanaka Y,Namba T,Azuma A,Mizushima T

更新日期：2010-09-15 00:00:00

abstract：:Polyamines (putrescine, spermidine and spermine) are aliphatic amines that are produced by the action of ornithine decarboxylase (ODC) in a rate-limiting and protein kinase C (PKC)-regulated step. Because high levels of polyamines are found in the synovial fluid of arthritic patients, the aim of the present study was ...

journal_title：Biochemical pharmacology

authors： Silva MA,Klafke JZ,Rossato MF,Gewehr C,Guerra GP,Rubin MA,Ferreira J

更新日期：2011-08-01 00:00:00

abstract：:A newly-synthesized derivative of prazosin, prazosinamine hydrochloride, was examined for its ability to antagonize the interaction of the alpha 1-adrenergic agonist phenylephrine with liver cells. Using a Ca2--selective electrode to measure changes in perfusate Ca2+ concentration, prazosinamine was found to be as eff...

journal_title：Biochemical pharmacology

authors： Armarego WL,Altin JG,Weir RC,Bygrave FL

更新日期：1987-05-15 00:00:00

abstract：:Since neurotensin is often co-stored with catecholamines and since it can excite the release of dopamine and norepinephrine, responses to this peptide might depend upon the activity of catecholaminergic systems. In this study, we used prostate cancer PC3 cells, which express neurotensin receptors and 12-adrenergic rec...

journal_title：Biochemical pharmacology

authors： Mitra SP,Carraway RE

更新日期：1999-06-15 00:00:00

abstract：:AM404 is a synthetic TRPV1/CB(1) hybrid ligand with inhibitory activity on the anandamide transporter and is used for the pharmacological manipulation of the endocannabinoid system. It has been recently described that acetaminophen is metabolised in the brain to form the bioactive N-acylphenolamine AM404 and therefore...

journal_title：Biochemical pharmacology

authors： Caballero FJ,Navarrete CM,Hess S,Fiebich BL,Appendino G,Macho A,Muñoz E,Sancho R

更新日期：2007-04-01 00:00:00

abstract：:Liver mitochondrial low-Km aldehyde dehydrogenase (ALDH2, EC 1.2.1.3), the isoform responsible for the conversion of acetaldehyde to acetate, is inhibited by the sulfoxide bioactivation products of Et2NC(O)SMe (from the alcohol aversion drug disulfiram), Pr2NC(O)SEt (the herbicide S-ethyl N,N-dipropylthiocarbamate), a...

journal_title：Biochemical pharmacology

authors： Staub RE,Quistad GB,Casida JE

更新日期：1999-11-01 00:00:00

abstract：:Bitter melon (Momordica charantia), commonly known as karela, has been reported to have hypoglycemic, antiviral, antidiabetic, and antitumor activities. In the present study, we have investigated the effects of oral feeding of karela fruit juice on the hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) ...

journal_title：Biochemical pharmacology

authors： Raza H,Ahmed I,Lakhani MS,Sharma AK,Pallot D,Montague W

更新日期：1996-11-22 00:00:00

abstract：:The N-type voltage-gated calcium channel (Ca(v)2.2) functions in neurons to regulate neurotransmitter release. It comprises a clinically relevant target for chronic pain. We have validated a calcium mobilization approach to assessing Ca(v)2.2 pharmacology in two stable Ca(v)2.2 cell lines: alpha1(B), alpha2delta, beta...

journal_title：Biochemical pharmacology

authors： Benjamin ER,Pruthi F,Olanrewaju S,Shan S,Hanway D,Liu X,Cerne R,Lavery D,Valenzano KJ,Woodward RM,Ilyin VI

更新日期：2006-09-14 00:00:00

abstract：:Carvedilol, a non-selective beta-adrenoreceptor blocker, has been shown to possess a high degree of cardioprotection in experimental models of myocardial damage. Reactive oxygen species have been proposed to be implicated in such situations, and antioxidants have been demonstrated to provide partial protection to the ...

journal_title：Biochemical pharmacology

authors： Santos DJ,Moreno AJ

更新日期：2001-01-15 00:00:00

abstract：:Accumulation of radioactive iron (59Fe) into isolated fragments of rat small intestine in the presence of two hydroxypyrones, maltol and ethyl maltol, was compared with that in the presence of another chelator of iron(III), nitrilotriacetic acid (NTA). The characteristics of uptake were similar with all three ligands....

journal_title：Biochemical pharmacology

authors： Levey JA,Barrand MA,Callingham BA,Hider RC

更新日期：1988-05-15 00:00:00

abstract：:Only very low levels of peroxidase activity were detected in castrated male hamster kidneys [1.0 +/- 0.8(S.E.) units/g protein], and chronic estrogen administration, either diethylstilbestrol (DES) or 17 beta-estradiol, for 1-5 months did not result in any appreciable increase in this activity. In contrast, hamster li...

journal_title：Biochemical pharmacology

authors： Klicka JK,Li SA,Li JJ

更新日期：1983-02-01 00:00:00

abstract：:In recent years, the concept of allosteric modulation of G-protein-coupled receptors (GPCRs) has matured and now represents an increasingly viable approach to drug discovery. This is evident in the fact that allosteric modulators have been reported for every class of GPCR, and several are currently in clinical trials ...

journal_title：Biochemical pharmacology

authors： Raddatz R,Schaffhauser H,Marino MJ

更新日期：2007-08-01 00:00:00

abstract：:The in vivo actions of two antimetabolites, acivicin (NSC-163501) and tiazofurin (NSC-286193), were examined on the enzymic programs of rat bone marrow. From the bone marrow of the femurs, 100,000 g supernatant fractions were prepared; enzymic activities were measured by isotopic assays, and cellularity was determined...

journal_title：Biochemical pharmacology

authors： Prajda N,Natsumeda Y,Ikegami T,Reardon MA,Szondy S,Hashimoto Y,Emrani J,Weber G

更新日期：1988-03-01 00:00:00

abstract：:Thioredoxin reductase (TR1) is a selenoprotein that is involved in cellular redox status control and deoxyribonucleotide biosynthesis. Many cancers, including lung, overexpress TR1, making it a potential cancer therapy target. Previous work has shown that TR1 knockdown enhances the sensitivity of cancer cells to antic...

journal_title：Biochemical pharmacology

authors： Poerschke RL,Moos PJ

更新日期：2011-01-15 00:00:00

abstract：:The metabolism of (1R)[1-3H]ethanol, [2-3H]lactate or [2-3H]xylitol was studied in hepatocytes from fed or T3-treated rats in the presence or absence of fructose or xylitol. The yields of tritium in ethanol, lactate, water, glycerol and glucose were determined. A simple model, describing the metabolic fate of tritium ...

journal_title：Biochemical pharmacology

authors： Vind C,Grunnet N

更新日期：1985-03-01 00:00:00

abstract：:The ex vivo sensitivity of murine pluripotent hematopoietic stem cells (CFU-S) and myeloid progenitor cells (CFU-GM) to 4-hydroperoxycyclophosphamide, ASTA Z 7557, phosphoramide mustard, acrolein, melphalan, and cis-platinum was determined in the absence and presence of known (disulfiram, diethyldithiocarbamate, cyana...

journal_title：Biochemical pharmacology

authors： Kohn FR,Sladek NE

更新日期：1985-10-01 00:00:00

abstract：:The effect of exhaustive exercise on the hepatobiliary transport of organic anions was investigated in rats. Animals were run on a rodent treadmill at 24 m/min up a 12% grade (152 +/- 15 min). Exercise resulted in significant hypoglycaemia (-46%) and increased plasma levels of lactate (+12%), together with a marked re...

journal_title：Biochemical pharmacology

authors： Villa JG,Collado PS,Almar MM,Gonzalez J

更新日期：1990-12-01 00:00:00

abstract：:The tissue distribution of captopril, an antihypertensive drug possessing a free sulfhydryl group, and its sulfur-conjugated metabolites was studied in rats by gas chromatography-mass spectrometry at 15, 30 and 60 min following a single 10 mg/kg oral dose of captopril. It was found that tissue accumulation of captopri...

journal_title：Biochemical pharmacology

authors： Drummer OH,Worland PJ,Jarrott B

更新日期：1983-05-15 00:00:00

abstract：:The effect of low M(r) heparin fragments (CY222) and fetal calf serum (FCS) on the level of fibronectin and fibrillar collagen mRNAs was investigated in smooth muscle cells (SMC) in culture. In the absence of FCS, addition of CY222 (100 micrograms/10(6) cells) to postconfluent early passage SMC resulted in a decrease ...

journal_title：Biochemical pharmacology

authors： Asselot-Chapel C,Combacau L,Labat-Robert J,Kern P

更新日期：1995-03-01 00:00:00

abstract：:Alcoholic ketoacidosis and diabetic ketoacidosis are life-threatening complications that share the characteristic features of high anion gap metabolic acidosis. Ketoacidosis is attributed in part to the massive release of ketone bodies (e.g., β-hydroxybutyrate; βOHB) from the liver into the systemic circulation. To da...

journal_title：Biochemical pharmacology

authors： Srinivasan MP,Shawky NM,Kaphalia BS,Thangaraju M,Segar L

更新日期：2019-02-01 00:00:00

abstract：:Polyacetylenic compounds of Panax ginseng roots have been shown to inhibit growth of several human malignant tumor cell lines. Panaxydol is known to be one of the cytotoxic polyacetylenic compounds of P. ginseng. In this study, we first showed that panaxydol decreased markedly the proliferation, and to a lesser extent...

journal_title：Biochemical pharmacology

authors： Moon J,Yu SJ,Kim HS,Sohn J

更新日期：2000-05-01 00:00:00

abstract：:When human saliva obtained after cigarette smoking was incubated in the presence of tryptamine, the formation of 1,2,3,4-tetrahydro-beta-carboline (TBC) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline (MTBC) was observed in a short time. After incubation with tryptamine (2.5 micrograms/microliter) for 10 min, the conce...

journal_title：Biochemical pharmacology

authors： Tsuchiya H,Ohtani S,Yamada K,Tajima K,Sato M

更新日期：1995-12-22 00:00:00

abstract：:The effects of injections of a synthetic adrenocorticotropin (ACTH 1-17, Synchrodyn) on the rate of DNA labeling in the metaphyseal bone of CD2F1 mice were tested on a chronopharmacological dosing schedule. Groups of mice that had been conditioned to a 12-hr light/12-hr dark schedule were injected at one of six differ...

journal_title：Biochemical pharmacology

authors： Walker WV,Russell JE,Simmons DJ,Scheving LE,Cornelissen G,Halberg F

更新日期：1985-04-15 00:00:00

abstract：:The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-inflammatory drugs is uncertain. Here we show that ibuprofen induces death of Walker 256 tumor cells independently on mitochondrial depolarization as estimated by flow cytometry using DioC(6)(3). Oligomycin increased mit...

journal_title：Biochemical pharmacology

authors： Campos CB,Degasperi GR,Pacífico DS,Alberici LC,Carreira RS,Guimarães F,Castilho RF,Vercesi AE

更新日期：2004-12-01 00:00:00