Abstract:
:When rat peritoneal leucocytes were incubated with carbon tetrachloride, a PLA2 was activated, eicosanoids were generated and lysosomal and cytoplasmic enzymes were released. The predominant eicosanoid generated was TXB2 with lesser amounts of PGE2, 6-keto PGF1 alpha and LTB4. Preincubation of the cells with two structurally unrelated thromboxane synthetase inhibitors reduced PLA2 activity and enzyme release and also reduced the total amounts of eicosanoids liberated. An anti-PGI2 antibody partially reversed the effects of thromboxane synthetase inhibitors indicating a role for endogenous PGI2 generation in the cytoprotective effects of these agents in this system. Exogenous PGI2 was also cytoprotective but the timing of its administration was critical. The cytoprotective effect of PGI2 was potentiated by a phosphodiesterase inhibitor, indicating a possible pivotal role of cAMP in cell protection.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Lynch TJ,Blackwell GJ,Moncada Sdoi
10.1016/0006-2952(85)90693-8subject
Has Abstractpub_date
1985-05-01 00:00:00pages
1515-22issue
9eissn
0006-2952issn
1873-2968pii
0006-2952(85)90693-8journal_volume
34pub_type
杂志文章abstract::The experiments were designed to investigate some details of the action of 3-methylcholanthrene (3-MC) on the regulation of transcription. After a single intraperitoneal dose of 3-MC a significant increase in the activities of both nucleolar and nucleoplasmic protein kinases in hepatic cells of young rats was found. T...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(82)90343-4
更新日期:1982-03-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(94)90081-7
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(89)90311-0
更新日期:1989-05-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(91)90108-h
更新日期:1991-05-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2005.12.030
更新日期:2006-04-14 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(85)90145-5
更新日期:1985-09-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2013-03-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(84)90289-2
更新日期:1984-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:1996-06-28 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 历史文章,杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-07-06 00:00:00
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pub_type: 杂志文章
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更新日期:2000-06-15 00:00:00
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更新日期:2011-10-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.bcp.2011.11.027
更新日期:2012-02-15 00:00:00
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pub_type: 杂志文章
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更新日期:1986-05-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2006.02.004
更新日期:2006-05-14 00:00:00
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pub_type: 杂志文章
doi:10.1016/0006-2952(86)90696-9
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(85)90607-0
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1991-07-25 00:00:00
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journal_title:Biochemical pharmacology
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更新日期:1997-07-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2015.05.014
更新日期:2015-08-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(91)90557-l
更新日期:1991-05-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(98)00205-6
更新日期:1998-11-15 00:00:00
abstract::This article has been retracted consistent with Elsevier Policy on Article Withdrawal. Please see . The Publisher apologises for any inconvenience this may cause. ...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2006.03.026
更新日期:2006-04-18 00:00:00
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pub_type: 杂志文章
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更新日期:1985-10-01 00:00:00