RETRACTED: Glutathione as a mediator of apoptotic cell signaling pathways.


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Biochem Pharmacol


Biochemical pharmacology


Cristofanon S,Dicato M,Ghibelli L,Diederich M




Has Abstract


2006-04-18 00:00:00








  • New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis.

    abstract::Tanshinone I (Tanshinone-1), a major active principle of the traditional Chinese medicine Salvia miltiorrhiza, possesses excellent anticancer properties, including inhibiting proliferation, angiogenesis and metastasis and overcoming multidrug resistance (MDR). However, its direct anticancer molecular target(s) remain ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Tian QT,Ding CY,Song SS,Wang YQ,Zhang A,Miao ZH

    更新日期:2018-08-01 00:00:00

  • Modifications of deoxycytidine kinase and deaminase activities by docosahexaenoic acid in normal and transformed rat fibroblasts.

    abstract::Deoxycytidine kinase (dCK) and deoxycytidine deaminase (dCDA) are two key enzymes in the activation and inactivation, respectively, of deoxycytidine (dCyd) and several chemotherapeutically important nucleoside analogues. To investigate whether supplementation of docosahexaenoic acid, an n-3 fatty acid found mainly in ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Cha MC,Meckling-Gill KA

    更新日期:2002-02-15 00:00:00

  • Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.

    abstract::Idiopathic pulmonary fibrosis (IPF) involves infiltration of leucocytes, pulmonary injury, fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor (TGF)-beta1 have been suggested to play a major role in the pathology and the myofibroblasts are derived from both lung epithelial cells...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Tanaka K,Tanaka Y,Namba T,Azuma A,Mizushima T

    更新日期:2010-09-15 00:00:00

  • Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells.

    abstract::A comparison of the effects of various phosphodiesterase (PDE) inhibitors upon cellular cAMP levels was undertaken in human neuroblastoma SH-SY5Y cells. When inhibitors such as rolipram and Ro 20 1724 (selective for the low Km cAMP-specific PDE) were used, cAMP levels were seen to rise dramatically under basal (< or =...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Morgan AJ,Murray KJ,Challiss RA

    更新日期:1993-06-22 00:00:00

  • Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.

    abstract::SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide) is a novel benzotriazine di-N-oxide which shows unusually high selective toxicity towards hypoxic cells, probably as a result of reductive bioactivation. Using an HPLC assay for the parent drug and its 2- and 4-electron reduction products (SR 4317 and SR 4330, respecti...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Walton MI,Workman P

    更新日期:1990-06-01 00:00:00

  • The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels.

    abstract::Valine residues in the pore region of SK2 (V366) and SK3 (V520) were replaced by either an alanine or a phenylalanine to evaluate the impact on the interactions with the allosteric blocker apamin. Unlike TEA which showed high sensitivity to phenylalanine mutated channels, the binding affinity of apamin to the phenylal...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Dilly S,Philippart F,Lamy C,Poncin S,Snyders D,Seutin V,Liégeois JF

    更新日期:2013-02-15 00:00:00

  • On the role of the peroxisome in the metabolism of drugs and xenobiotics.

    abstract::One of the most rapidly developing areas of organellar biology, and one with major involvements in biochemical pharmacology, is that of peroxisomal function. In this commentary, several recent research findings in this area are described, along with their significance in relation to the metabolism of drugs and xenobio...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Masters CJ

    更新日期:1998-09-15 00:00:00

  • Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells.

    abstract::Multidrug resistance mediated by the multidrug resistance-associated protein MRP1 is associated with decreased drug accumulation, which is in turn dependent on cellular glutathione. We have reported that verapamil, an inhibitor of drug transport, caused a decrease in cellular glutathione in CCRF-CEM/E1000 MRP1-overexp...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Cullen KV,Davey RA,Davey MW

    更新日期:2001-08-15 00:00:00

  • Effects of hypophysectomy and thyroxine on the expression of hepatic oestrogen, hydroxysteroid and phenol sulphotransferases.

    abstract::Sulphation in rats, and other mammals, is carried out by a family of sulphotransferase isoenzymes, which can be further subdivided into oestrogen, hydroxysteroid and phenol sulphotransferases. We have examined the effects of hypophysectomy on the activity and expression of representative members of the three major sul...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Borthwick EB,Voice MW,Burchell A,Coughtrie MW

    更新日期:1995-05-17 00:00:00

  • Inhibition of S-nitrosation of reduced glutathione in aerobic solutions of nitric oxide by phosphate and other inorganic anions.

    abstract::Reduced glutathione is nitrosated in aerobic solutions of nitric oxide under physiological conditions; however, the extent of S-nitrosation was found to be dependent on the inorganic anions present. Of nine anions tested, the bifunctional anions, arsenate, phosphate, and pyrophosphate (40 mM), inhibited the S-nitrosat...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: DeMaster EG,Quast BJ,Mitchell RA

    更新日期:1997-02-21 00:00:00

  • Stimulation of cadmium uptake by estradiol in the kidney of male rats treated with cadmium.

    abstract::The present study was carried out to analyze the sex differences in the retention of Cd in rats treated with a small amount of Cd, and its mechanisms. Cd and Zn concentrations in the kidney and liver of female rats treated with 28 nmol Cd or 1 nmole Zn were significantly higher than those in male rats. Pretreatment wi...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Nishiyama S,Onosaka S,Taguchi T,Konishi Y,Tanaka K,Kinebuchi H

    更新日期:1988-08-15 00:00:00

  • Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets.

    abstract::UDP-glucuronosyltransferases (UGTs) are essential drug-conjugation enzymes that metabolize a variety of endobiotic and xenobiotic substrates. The molecular characteristics of UGTs have been extensively investigated in humans, but remain to be investigated in common marmosets, a nonhuman primate species widely used in ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Uno Y,Uehara S,Inoue T,Kawamura S,Murayama N,Nishikawa M,Ikushiro S,Sasaki E,Yamazaki H

    更新日期:2020-02-01 00:00:00

  • Superoxide anion mediates the L-selectin down-regulation induced by non-steroidal anti-inflammatory drugs in human neutrophils.

    abstract:UNLABELLED:Non-steroidal anti-inflammatory drugs (NSAIDs) induce the shedding of L-selectin in human neutrophils through a mechanism still not well understood. In this work we studied both the functional effect of NSAIDs on the neutrophils/endothelial cells dynamic interaction, and the potential involvement of reactive...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Domínguez-Luis M,Herrera-García A,Arce-Franco M,Armas-González E,Rodríguez-Pardo M,Lorenzo-Díaz F,Feria M,Cadenas S,Sánchez-Madrid F,Díaz-González F

    更新日期:2013-01-15 00:00:00

  • Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism.

    abstract::The influence of both short- and long-term ethanol exposure on the lipid metabolism was determined in the human hepatoma cell line HepG2. Ethanol did not cause any cytotoxicity or lipid peroxidation even after 7 days of 100 mM ethanol treatment of HepG2 cells. Incubation of cells in the presence of [1-(14)C]ethanol de...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Jiménez-López JM,Carrasco MP,Segovia JL,Marco C

    更新日期:2002-04-15 00:00:00

  • Inhibitory effect of eugenol on non-enzymatic lipid peroxidation in rat liver mitochondria.

    abstract::The anti-peroxidative activity of eugenol on Fe(2+)-ascorbate- and Fe(2+)-H2O2-induced lipid peroxidation was studied using rat liver mitochondria. Eugenol inhibited thiobarbituric acid reactive substance (TBARS) formation induced by both the systems in addition to oxygen uptake and mitochondrial swelling induced by F...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Nagababu E,Lakshmaiah N

    更新日期:1992-06-09 00:00:00

  • Studies on the action of nystatin on cultured rat myocardial cells and cell membranes, isolated rat hearts, and intact rats.

    abstract::The action of nystatin, a polyene antibiotic, was studied in rat myocardial cells, isolated rat hearts, and intact rats. Myocardial cells responded to 10 and 25 micrograms nystatin/ml with arrhythmias that could be minimized by elevated concentrations of K+ and Mg2+ or reversed by washing the cells. Similarly, the iso...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Aszalos A,Bradlaw JA,Reynaldo EF,Yang GC,El-Hage AN

    更新日期:1984-12-01 00:00:00

  • Correlation [corrected] of salinity with flavin-containing monooxygenase activity but not cytochrome P450 activity in the euryhaline fish (Platichthys flesus)

    abstract::To test the association between flavin-containing monooxygenases (FMOs) and osmoregulation, saltwater-adapted euryhaline flounder (Platichthys flesus) were statically exposed to 34 (ambient), 25, and 15 parts per thousand (/1000) salinity for 1 or 2 weeks. FMO activity (thiourea S-oxidase) was assayed in gill and live...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Schlenk D,Peters LD,Livingstone DR

    更新日期:1996-09-13 00:00:00

  • Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells.

    abstract::AKT1 (c-AKT, PKBalpha) is the cellular homolog of the protein-serine/threonine kinase oncogene, v-akt. AKT1 is activated through the insulin and platelet-derived growth factor signaling pathways in transfected fibroblasts, but little is known about the regulation of endogenous AKT1 in tumor cells. AKT1 levels were hig...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ahmad S,Singh N,Glazer RI

    更新日期:1999-08-01 00:00:00

  • Gene regulation of heme oxygenase-1 as a therapeutic target.

    abstract::Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme degradation. HO regulates the cellular content of the pro-oxidant heme and produces catabolites with physiological functions. HO-1 is induced by a host of oxidative stress stimuli, and the activation of HO-1 gene expression is considere...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Immenschuh S,Ramadori G

    更新日期:2000-10-15 00:00:00

  • Degradation of glyceraldehyde-3-phosphate dehydrogenase induced by acetylleucine chloromethyl ketone in U937 cells.

    abstract::We examined whether any changes were induced in cellular proteins by an inhibitor of acylpeptide hydrolase (ACPH) (EC, acetylleucine chloromethyl ketone (ALCK), which was shown in our previous report to induce apoptosis of human U937 cells. Extract prepared from U937 cells in 0.05% Triton X-100-PBS was incub...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Yamaguchi M,Tsuchiya Y,Chikuma T,Hojo H

    更新日期:2002-05-15 00:00:00

  • A water-soluble derivative of prazosin prazosinamine hydrochloride [1-(4'-amino-6',7'-dimethoxyquinazolin-2'-yl)-4-(6''-aminohexanoyl) piperazine hydrochloride], reversibly inhibits the calcium-mobilizing action of alpha 1-adrenergic agonists in the perfu

    abstract::A newly-synthesized derivative of prazosin, prazosinamine hydrochloride, was examined for its ability to antagonize the interaction of the alpha 1-adrenergic agonist phenylephrine with liver cells. Using a Ca2--selective electrode to measure changes in perfusate Ca2+ concentration, prazosinamine was found to be as eff...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Armarego WL,Altin JG,Weir RC,Bygrave FL

    更新日期:1987-05-15 00:00:00

  • Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart.

    abstract::The effects of the anti-inflammatory drugs diclofenac, piroxicam, indomethacin, naproxen, nabumetone, nimesulide, and meloxicam on mitochondrial respiration, ATP synthesis, and membrane potential were determined. Except for nabumetone and naproxen, the other drugs stimulated basal and uncoupled respiration, inhibited ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Moreno-Sánchez R,Bravo C,Vásquez C,Ayala G,Silveira LH,Martínez-Lavín M

    更新日期:1999-04-01 00:00:00

  • Endothelin receptors in adult human and swine isolated ventricular cardiomyocytes.

    abstract::The present study aimed to investigate endothelin-1 (ET-1) receptors in human and swine cardiomyocytes with binding studies using ET(A) and ET(B) selective receptor antagonists (BMS-182874 and BQ-788, respectively). Cell distribution of mRNA expression for ET(A) and ET(B) subtypes was investigated by in situ hybridiza...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Modesti PA,Vanni S,Paniccia R,Perna A,Maccherini M,Lisi G,Sani G,Neri Serneri GG

    更新日期:1999-07-15 00:00:00

  • Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma.

    abstract::Epidemiological and experimental animal data indicate that exposure to both metals and metalloid species exacerbates the risk of human diseases, particularly cancers. Vascular endothelial growth factor (VEGF), which performs a primary function in both tumor progression and angiogenesis, is up-regulated due to exposure...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lee M,Hwang JT,Yun H,Kim EJ,Kim MJ,Kim SS,Ha J

    更新日期:2006-06-28 00:00:00

  • Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat.

    abstract::Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were examined in several tissues of normal and hypophysectomized male and female rats. Significant sex differences in the mean AChE activities of normal rats were observed in the superior cervical ganglion (three times more activity in males) and...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Edwards JA,Brimijoin S

    更新日期:1983-04-01 00:00:00

  • Contribution of non-ADH pathways to ethanol oxidation in hepatocytes from fed and hyperthyroid rats. Effect of fructose and xylitol.

    abstract::The metabolism of (1R)[1-3H]ethanol, [2-3H]lactate or [2-3H]xylitol was studied in hepatocytes from fed or T3-treated rats in the presence or absence of fructose or xylitol. The yields of tritium in ethanol, lactate, water, glycerol and glucose were determined. A simple model, describing the metabolic fate of tritium ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Vind C,Grunnet N

    更新日期:1985-03-01 00:00:00

  • Desensitization to nitroglycerin in vascular smooth muscle from rat and human.

    abstract::Guanylate cyclase in high speed supernatant fractions obtained from rat thoracic aorta or human coronary arteries pretreated with nitroglycerin exhibited a marked desensitization to activation by nitroglycerin, nitroprusside, and nitric oxide. However, activation of soluble guanylate cyclase by arachidonic acid was un...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Waldman SA,Rapoport RM,Ginsburg R,Murad F

    更新日期:1986-10-15 00:00:00

  • Superoxide scavenging effect of Ginkgo biloba extract on serotonin-induced mitogenesis.

    abstract::We have reported previously that serotonin (5-HT) stimulates the mitogenesis of bovine pulmonary artery smooth muscle cells (SMCs) through active transport of 5-HT and cellular signaling that includes elevation of superoxide (O2.-) and enhancement of protein tyrosine phosphorylation. Ginkgo biloba extract 501 (EGb 501...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lee SL,Wang WW,Lanzillo J,Gillis CN,Fanburg BL

    更新日期:1998-08-15 00:00:00

  • Binding of [3H]quinuclidinyl benzilate to intestinal mucus. An artifact in identification of epithelial cell muscarinic receptors.

    abstract::The widely used muscarinic receptor ligand [3H]quinuclidinyl benzilate ([3H]QNB) was found to bind in a site-specific but artifactual manner to rat intestinal mucus, obscuring specific binding to muscarinic receptors on intestinal epithelial cells. Atropine inhibited [3H]QNB binding to mucus with an apparent IC50 of 2...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Rimele TJ,Gaginella TS

    更新日期:1982-02-15 00:00:00

  • Allosteric effects of antagonists on signalling by the chemokine receptor CCR5.

    abstract::Antagonists of the chemokine receptor, CCR5, may provide important new drugs for the treatment of HIV-1. In this study we have examined the mechanism of action of two functional antagonists of the chemokine receptor CCR5 (UK-396,794, UK-438,235) in signalling and internalisation assays using CHO cells expressing CCR5....

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Haworth B,Lin H,Fidock M,Dorr P,Strange PG

    更新日期:2007-09-15 00:00:00