RETRACTED: Glutathione as a mediator of apoptotic cell signaling pathways.


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Biochem Pharmacol


Biochemical pharmacology


Cristofanon S,Dicato M,Ghibelli L,Diederich M




Has Abstract


2006-04-18 00:00:00








  • Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases

    abstract::Compounds of the mevalonate pathway containing a terminal di- or triphosphate (mev-PP or mev-PPP) were tested as substrates of several enzyme ligases (T4 RNA ligase, T4 DNA ligase, firefly luciferase and other ligases) for the synthesis of ATP derivatives of the mev-pppA or mev-ppppA type. T4 RNA ligase, in the presen...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Sillero MA,de Diego A,Tavares JE,Silva JA,Pérez-Zúñiga FJ,Sillero A

    更新日期:2009-08-15 00:00:00

  • Oligogalacturonic acid inhibit bone resorption and collagen degradation through its interaction with type I collagen.

    abstract::In this study, we showed that oligogalacturonic acid (OGA) purified from flax pectin inhibit in vitro osteoclastic bone resorption in a dose-dependent manner. The OGA inhibitory effect was neither linked to an effect on osteoclast apoptosis, nor to an inhibition of cathepsin K activity. By means of an in vitro collage...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lion JM,Mentaverri R,Rossard S,Jullian N,Courtois B,Courtois J,Brazier M,Mazière JC,Kamel S

    更新日期:2009-12-15 00:00:00

  • Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages.

    abstract::The effects of three phenothiazines, promethazine, thiazinamium chloride and chlorpromazine, on macrophage function were investigated in rat alveolar macrophages. The study focused on thromboxane B2 (TxB2) synthesis, zymosan phagocytosis, and hexosemonophosphate (HMP) shunt activity in these phagocytes. TxB2 synthesis...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Chang J,Piperata S,Skowronek M,Lewis AJ

    更新日期:1983-09-15 00:00:00

  • New molecular targets for the treatment of osteoarthritis.

    abstract::Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Current treatments are focused on symptomatic relief but they lack efficacy to control the progression of this disease which is a leading cause of disability...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Alcaraz MJ,Megías J,García-Arnandis I,Clérigues V,Guillén MI

    更新日期:2010-07-01 00:00:00

  • Characterisation of multidrug-resistant Ehrlich ascites tumour cells selected in vivo for resistance to etoposide.

    abstract::An Ehrlich ascites tumour cell line (EHR2) was selected for resistance to etoposide (VP16) by in vivo exposure to this agent. The resulting cell line (EHR2/VP16) was 114.3-, 5.7-, and 4.0-fold resistant to VP16, daunorubicin, and vincristine, respectively. The amount of salt-extractable immunoreactive topoisomerase II...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Nielsen D,Maare C,Eriksen J,Litman T,Friche E,Skovsgaard T

    更新日期:2000-08-01 00:00:00

  • Dependence of endothelin-1 secretion on Ca2+.

    abstract::The role of Ca2+ and protein kinase C (PKC) activity in the release of immunoreactive endothelin-1 (ET-1) from cultured porcine aortic endothelial cells of first or second passage has been studied. ET-1 accumulation within cells and secretion into cell-conditioned medium over 3 and/or 5 hr was measured. Confluent cell...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Brunner F

    更新日期:1995-06-16 00:00:00

  • Venom-derived modulators of epilepsy-related ion channels.

    abstract::Epilepsy is characterised by spontaneous recurrent seizures that are caused by an imbalance between neuronal excitability and inhibition. Since ion channels play fundamental roles in the generation and propagation of action potentials as well as neurotransmitter release at a subset of excitatory and inhibitory synapse...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Chow CY,Absalom N,Biggs K,King GF,Ma L

    更新日期:2020-11-01 00:00:00

  • The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.

    abstract::Ischemia/reperfusion (I/R) injury constitutes a major reason for failure of liver surgeries and transplantation. I/R injury is more severe in steatotic livers and limits their use in transplantation. Here, we present a novel and selective Toll-like receptor 9 (TLR9) antagonist COV08-0064 and test its potential to prot...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Shaker ME,Trawick BN,Mehal WZ

    更新日期:2016-07-15 00:00:00

  • Protection of erythrocytes against hemolytic agents by cyclodextrin polysulfate.

    abstract::Cyclodextrins generally exhibit hemolytic activity, some at concentrations as low as 1-10 mg/mL or lower. However, we found previously that a highly polysulfated cyclodextrin has no demonstrable hemolytic activity (Macarak et al., Biochem Pharmacol 42: 1502-1503, 1991). In the present study, we determined that, in fac...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Weisz PB,Kumor K,Macarak EJ

    更新日期:1993-03-09 00:00:00

  • Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence.

    abstract::In this paper, we illustrate how a proteomic analysis can be useful to approach complex biological problems, in this case the concept of stress-induced premature senescence (SIPS). According to the stochastic theories of ageing, damage that accumulate with time in the cellular components are responsible for cellular a...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Dierick JF,Eliaers F,Remacle J,Raes M,Fey SJ,Larsen PM,Toussaint O

    更新日期:2002-09-01 00:00:00

  • Differential effects of sedative and anticonvulsant barbiturates on specific [3H]GABA binding to membrane preparations from rat brain cortex.

    abstract::The sensitivity to barbiturates of [3H]GABA binding to synaptosomal membrane fractions from rat cortex has been examined. We show that a range of anaesthetic/sedative barbiturates enhance GABA binding in the presence of chloride or other ions that interact with the associated ionophore. Furthermore, picrotoxinin and t...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Whittle SR,Turner AJ

    更新日期:1982-09-15 00:00:00

  • P2X7 receptor and the NLRP3 inflammasome: Partners in crime.

    abstract::Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular energetics and which on the other is a ubiquitous signaling molecule when released into the extracellular media. Extracellular ATP accumulates in inflammatory environments where it acts as a damage-associated molecular pattern...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Pelegrin P

    更新日期:2020-12-20 00:00:00

  • Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells.

    abstract::Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the fourth most frequent cause of cancer-related death worldwide. Sorafenib is the first line recommended therapy for patients with locally advanced/metastatic HCC. The low response rate is attributed to intrinsic resistance of HCC cell...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Rodríguez-Hernández MA,de la Cruz-Ojeda P,Gallego P,Navarro-Villarán E,Staňková P,Del Campo JA,Kučera O,Elkalaf M,Maseko TE,Červinková Z,Muntané J

    更新日期:2020-06-01 00:00:00

  • Desensitization of adenylate cyclase responses following exposure to IP prostanoid receptor agonists. Homologous and heterologous desensitization exhibit the same time course.

    abstract::Pretreatment of NG108-15 cells with 0.03-25 microM prostaglandin E1 (PGE1) produced decreases in the maximal stimulation of adenylate cyclase activity produced by iloprost, N-ethylcarboxamidoadenosine and sodium fluoride. The rate of desensitization to all three agents was dependent on the concentration of PGE1 used, ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Krane A,MacDermot J,Keen M

    更新日期:1994-03-15 00:00:00

  • Effect of spin traps in isolated rat hepatocytes and liver microsomes.

    abstract::Spin traps are increasingly employed in the detection of free radicals in biological systems, including liver microsomes and isolated hepatocytes. Two spin traps phenyl-t-butyl nitrone (PBN) and 4-pyridyl-l-oxide-t-butyl nitrone (4-POBN) have been tested for their effects on hepatocyte viability and mixed-function oxi...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Albano E,Cheeseman KH,Tomasi A,Carini R,Dianzani MU,Slater TF

    更新日期:1986-11-15 00:00:00

  • Unique inhibitory action of the synthetic compound 2-[N-(2-aminoethyl)-N-(5-isoquinolinesulfonyl)] amino-N-(4-chlorocinnamyl)-N-methylbenzylamine (CKA-1306) against calcium/calmodulin-dependent protein kinase I.

    abstract::A newly synthesized compound, 2-[N-(2-aminoethyl)-N-(5-isoquinolinesulfonyl)]amino-N-(4-chlorocinnamyl )-N-methylbenzylamine (CKA-1306), was found to inhibit cyclic AMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase I (CaMK I) with IC50 values of 1.6+/-0.14 and 2.5+/-0.16 microM, respectiv...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Sakaguchi H,Yokokura H,Terada O,Naito Y,Nimura Y,Hidaka H

    更新日期:1998-08-01 00:00:00

  • GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization.

    abstract::GABAB receptors assemble from GABAB1 and GABAB2 subunits. GABAB2 additionally associates with auxiliary KCTD subunits (named after their K(+) channel tetramerization-domain). GABAB receptors couple to heterotrimeric G-proteins and activate inwardly-rectifying K(+) channels through the βγ subunits released from the G-p...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Adelfinger L,Turecek R,Ivankova K,Jensen AA,Moss SJ,Gassmann M,Bettler B

    更新日期:2014-10-01 00:00:00

  • Reduction of dihydroxyphenylacetic acid by a novel enzyme in the rat brain.

    abstract::A novel enzyme that converts dihydroxyphenylacetic acid (DOPAC) to dihydroxyphenylethanol (DOPET) was found to be present in the microdialysate of the rat brain. The enzyme, named DOPAC reductase, was inhibited by EDTA and stimulated by divalent cations like Zn2+, Mn2+, Co2+ and Cu2+. Its Km, pH optimum and temperatur...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Xu CL,Sim MK

    更新日期:1995-10-26 00:00:00

  • Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis.

    abstract::The inhibitory effect of a range of nitroimidazole-derivatives on H2 production by metronidazole resistant (CDC-85) and susceptible (C1-NIH) Trichomonas vaginalis strains was investigated. The 2-, 4-, and 5-nitro-derivatives used had one-electron reduction potentials within the range -250 to -525 mV. Nitroimidazole co...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Yarlett N,Yarlett NC,Lloyd D

    更新日期:1986-05-15 00:00:00

  • The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.

    abstract::Previously, we reported that the multidrug resistance proteins MRP1, MRP2 and MRP3 confer resistance to therapeutic antifolates by mediating their cellular extrusion. We now determined whether MRPs also play a role in controlling cellular homeostasis of natural folates. In MRP1, MRP2 and MRP3-transfected 2008 human ov...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Hooijberg JH,Peters GJ,Assaraf YG,Kathmann I,Priest DG,Bunni MA,Veerman AJ,Scheffer GL,Kaspers GJ,Jansen G

    更新日期:2003-03-01 00:00:00

  • Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic acid on platelet activation and degranulation.

    abstract::Activated blood platelets play crucial role in restenosis due to their fundamental significance in thrombus formation. Therefore, platelets are attractive targets for the inhibition with a variety of antagonists. In this study, we present direct evidence that GR144053F [non-peptide antagonist of glycoprotein IIb-IIIa ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Rozalski M,Boncler M,Golanski J,Watala C

    更新日期:2001-11-15 00:00:00

  • Triangular gold nanoparticles conjugated with peptide ligands: a new class of inhibitor for Candida albicans secreted aspartyl proteinase.

    abstract::The aim of this study was to find the peptide ligands to inhibit Candida albicans secreted aspartyl proteinase 2 (Sap2). First, a ligand library, containing 300 different peptides, was constructed, and their interaction with Sap2 was separately calculated by molecular dynamic software. Second, 10 peptide ligands with ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Jebali A,Hajjar FH,Hekmatimoghaddam S,Kazemi B,De La Fuente JM,Rashidi M

    更新日期:2014-08-15 00:00:00

  • Expression, maturation, and rhodamine-based fluorescence assay of human cathepsin K expressed in CHO cells.

    abstract::Cathepsin K is a cysteine protease that degrades type I human collagen during bone resorption. We have expressed the recombinant human cathepsin K in Chinese hamster ovary (CHO) cells as a pre-proenzyme and demonstrated that it is processed intracellularly to an active enzyme form and that only the proenzyme form is s...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Claveau D,Riendeau D,Mancini JA

    更新日期:2000-09-15 00:00:00

  • Indirect evidence for the metabolic dehalogenation of tetrafluorodiethylstilbestrol by rat and hamster liver and kidney microsomes. Species- and organ-dependent differences.

    abstract::In order to assess the significance of the catechol pathway for the carcinogenic activity of diethylstilbestrol (DES), the stability of 3',5',3",5"-tetrafluoro-DES (TF-DES) against metabolic catechol formation was examined in vitro. A radioenzymatic assay was used for determining the estrogen hydroxylase activity of l...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Hey MM,Haaf H,McLachlan JA,Metzler M

    更新日期:1986-07-01 00:00:00

  • The characterization of perfluorosuccinate as an inhibitor of gluconeogenesis in isolated rat hepatocytes.

    abstract::The effects on metabolism of the fluorinated dicarboxylic acid, perfluorosuccinate, were examined in hepatocytes from fasted rats. Perfluorosuccinate (5 mM) inhibited gluconeogenesis from lactate by 80% and from pyruvate by 40%. Significant inhibition (up to 30%) occurred at a concentration of perfluorosuccinate of 50...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Gregory RB,Berry MN

    更新日期:1989-09-01 00:00:00

  • Accumulation of gamma-globin mRNA and induction of irreversible erythroid differentiation after treatment of CML cell line K562 with new doxorubicin derivatives.

    abstract::Human chronic myelogenous leukemia (CML) cell line K562 can be chemically induced to differentiate and express embryonic and fetal globin genes. In this study, the effects of doxorubicin (DOX), an inducer of K562 cell erythroid differentiation, with those of epidoxorubicin (EDOX) as well as newly synthesized derivativ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Szulawska A,Arkusinska J,Czyz M

    更新日期:2007-01-15 00:00:00

  • Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases.

    abstract::Rat, rabbit and human serum albumins were immobilized on an HPLC stationary phase, and the resulting phases were tested for their abilities to determine the extent and enantioselectivity of ligand binding to the respective albumins. A series of achiral and chiral compounds were chromatographed on the phases including ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Massolini G,Aubry AF,McGann A,Wainer IW

    更新日期:1993-10-05 00:00:00

  • Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines.

    abstract::Arsenic trioxide (ATO) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, but successful application of this agent may occasionally require the use of sensitizing strategies. The present work demonstrates that the flavonoids quercetin and chrysin cooperate with ATO to induce apoptosis...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ramos AM,Aller P

    更新日期:2008-05-15 00:00:00

  • Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism.

    abstract::Human recombinant superoxide dismutase (SOD) was modified into a mannosylated form (Man-SOD), and its cellular uptake and inhibitory effect on superoxide anion release were studied in vitro, using cultured mouse peritoneal macrophages. [111In]Man-SOD was taken up by the macrophages to a great extent, whereas no signif...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Takakura Y,Masuda S,Tokuda H,Nishikawa M,Hashida M

    更新日期:1994-03-02 00:00:00

  • The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells.

    abstract::LLC-PK1 cells have been used as an in vitro model to study the nephrotoxicity of the antitumor drug cisplatin. A concentration-dependent cytotoxicity of cisplatin, measured as lactate dehydrogenase leakage and amount of protein remaining attached to the culture plate, was observed. At a cisplatin concentration of 0.4 ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Baldew GS,Boymans AP,Mol JG,Vermeulen NP

    更新日期:1992-07-22 00:00:00