RETRACTED: Glutathione as a mediator of apoptotic cell signaling pathways.

abstract：:The characteristics of the uptake of acetaminophen (N-acetyl-p-aminophenol or paracetamol, APAP) in incubations of isolated rat liver cells were consistent with diffusion of the drug being the predominant mechanism of APAP influx in these cells at concentrations above 0.5 mM. At lower substrate concentrations (below 0...

journal_title：Biochemical pharmacology

authors： McPhail ME,Knowles RG,Salter M,Dawson J,Burchell B,Pogson CI

更新日期：1993-04-22 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are members of a class of ancient, highly conserved signalling molecules that play major roles in embryonic axis determination, organ development, tissue repair, and regeneration throughout the animal kingdom. The bone morphogenetic proteins are potent developmental morphogens that a...

journal_title：Biochemical pharmacology

authors： Kaplan FS,Shore EM

更新日期：1998-02-15 00:00:00

abstract：:Benzoporphyrin derivative, monoacid ring A (BPD-MA), currently in clinical trials as a photosensitizer for photodynamic therapy for cancer, consists of two regioisomers (A1 and A2) present in equal proportions. The contribution of the regioisomers to the overall photosensitizing potency of BPD-MA was tested in vitro a...

journal_title：Biochemical pharmacology

authors： Richter AM,Jain AK,Canaan AJ,Waterfield E,Sternberg ED,Levy JG

更新日期：1992-06-09 00:00:00

abstract：:Antibodies raised against purified hog renal or intestinal brush border protein or against purified hog kidney angiotensin I converting enzyme (ACE) were used to characterize renal and intestinal brush border ACE by techniques of differential solubilization, fused-rocket, line absorption and crossed-immunoelectrophore...

journal_title：Biochemical pharmacology

authors： Ward PE,Sheridan MA

更新日期：1983-01-15 00:00:00

abstract：:ICRF-193 [meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane], a bisdioxopiperazine compound, has been shown to be a catalytic inhibitor of DNA topoisomerase II by stabilizing the enzyme in the form of a closed "protein clamp," an intermediate form in the catalytic cycle (Roca et al., Proc Natl Acad Sci USA 91: 1781-1785, 1...

journal_title：Biochemical pharmacology

authors： Sato M,Ishida R,Narita T,Kato J,Ikeda H,Fukazawa H,Andoh T

更新日期：1997-09-01 00:00:00

abstract：:The effects of streptozotocin (STZ)-induced diabetes on acetaminophen metabolism and hepatotoxicity in male Sprague-Dawley (SD) and Long Evans Hooded (LEH) rats were compared. In agreement with earlier studies, normal SD rats were more resistant to acetaminophen-induced hepatic necrosis than normal LEH rats. In contra...

journal_title：Biochemical pharmacology

authors： Price VF,Jollow DJ

更新日期：1986-02-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death. Different signaling pathways are de-regulated in this pathogenesis, among them the epidermal growth factor receptor one (EGFR/Erb1). Here we show that blockage of this pathway by the tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyqui...

journal_title：Biochemical pharmacology

authors： Caja L,Sancho P,Bertran E,Ortiz C,Campbell JS,Fausto N,Fabregat I

更新日期：2011-12-01 00:00:00

abstract：:We have previously reported that Gen-27, a newly synthesized flavonoid, exhibits anticancer effects against human colorectal cancer cells. In this study, we investigated the anticancer effects in human breast cancer cell lines and its underlying mechanisms. We demonstrated that Gen-27 inhibited the growth and prolifer...

journal_title：Biochemical pharmacology

authors： Tao L,Wei L,Liu Y,Ding Y,Liu X,Zhang X,Wang X,Yao Y,Lu J,Wang Q,Hu R

更新日期：2017-02-01 00:00:00

abstract：:The effects of 2,5-hexanedione (2,5 HD) on skeletal proteins of red blood cells (RBCs) were investigated both in vitro (human RBCs) and in vivo in male Sprague-Dawley rats which had been treated with the drug for several days. We found that 2,5 HD induced the following major changes in the electrophoretic pattern of t...

journal_title：Biochemical pharmacology

authors： Mallozzi C,Scorza G,Frontali N,Minetti M

更新日期：1989-08-15 00:00:00

abstract：:We have examined, relative to clofibric acid (CPIB), the effects of a chemical series of phenoxyacetic acids and of two asymmetric CPIB analogues, the R(+)- and S(-)-enantiomers of 2-(4-chlorophenoxy)propionic acid (4-CPPA) and 2-(4-chlorophenoxy)butyric acid (4-CPBA), on hepatic peroxisome proliferation both in vivo ...

journal_title：Biochemical pharmacology

authors： Esbenshade TA,Kamanna VS,Newman HA,Tortorella V,Witiak DT,Feller DR

更新日期：1990-09-15 00:00:00

abstract：:We have previously shown that chronic administration of the 5-hydroxytryptamine (5-HT) receptor antagonist, ritanserin (10 mg/kg/day) or the monoamine oxidase type A inhibitor (MAOI), clorgyline (2 mg/kg/day), results in a reduction in 5-HT2 receptor number in rat cerebral cortex. This study investigates the effects o...

journal_title：Biochemical pharmacology

authors： Twist EC,Brammer MJ,Stephenson JD,Corn TH,Campbell IC

更新日期：1990-11-01 00:00:00

abstract：:The anticancer drug cis-diamminedichloroplatinum(II) (cisplatin) has been shown previously to form adducts preferentially within internucleosomal or linker DNA rather than to DNA within the nucleosome. To determine whether other "open" regions of chromatin have an increased affinity for cisplatin, adduct formation wit...

journal_title：Biochemical pharmacology

authors： Bubley GJ,Xu J,Kupiec N,Sanders D,Foss F,O'Brien M,Emi Y,Teicher BA,Patierno SR

更新日期：1996-03-08 00:00:00

abstract：:N-[(2'-Dimethylamino)ethyl]acridine-4-carboxamide (DACA) is a new anticancer agent currently undergoing clinical trials. The metabolism of DACA to acridone metabolites by aldehyde oxidase (AO) (EC 1.2.3.1) appears to play a major role in its elimination in human patients and rodents. The aim of this study was to compa...

journal_title：Biochemical pharmacology

authors： Schofield PC,Robertson IG,Paxton JW

更新日期：2000-01-15 00:00:00

abstract：:Coenzyme CoQ10 (CoQ10), a ubiquinone compound, has been reported to inhibit tyrosinase activity and melanin production in melanoma B16F10 cells. However, the molecular mechanism underlying this inhibitory effect is poorly understood. In this paper we aimed to investigate the molecular mechanisms involved in the anti-m...

journal_title：Biochemical pharmacology

authors： Hseu YC,Ho YG,Mathew DC,Yen HR,Chen XZ,Yang HL

更新日期：2019-06-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target for anticancer drug design. In this study, we have achieved a new type of STAT3 inhibitors based on structural modifications on shikonin scaffold, guided by compu...

journal_title：Biochemical pharmacology

authors： Qiu HY,Fu JY,Yang MK,Han HW,Wang PF,Zhang YH,Lin HY,Tang CY,Qi JL,Yang RW,Wang XM,Zhu HL,Yang YH

更新日期：2017-12-15 00:00:00

abstract：:The addition of agents, such as tumor necrosis factor-alpha, to human peripheral neutrophils (HPPMN) induces priming, which enhances the receptor-mediated superoxide (O2-) generation and tyrosine phosphorylation of several HPPMN proteins. Lidocaine, a local anesthetic, inhibited both enhanced O2- generation and tyrosi...

journal_title：Biochemical pharmacology

authors： Kanbara T,Tomoda MK,Sato EF,Ueda W,Manabe M

更新日期：1993-04-22 00:00:00

abstract：:5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3). PTAU has inhibition constant (K(is)) values of 248 and 353 nM towards UrdPase from mouse and human livers, respectively. PTAU was ...

journal_title：Biochemical pharmacology

authors： el Kouni MH,Goudgaon NM,Rafeeq M,Al Safarjalani ON,Schinazi RF,Naguib FN

更新日期：2000-09-15 00:00:00

abstract：:We have shown previously that Z-1,1-dichloro-2,3-diphenylcyclopropane (a.k.a. Analog II, A(II)) inhibits human breast cancer cell proliferation regardless of estrogen receptor status or estrogen sensitivity, and that its cellular targets include microtubules. In the present study, we investigated the apoptosis-inducin...

journal_title：Biochemical pharmacology

authors： Balachandran R,ter Haar E,Yalowich JC,Welsh MJ,Grant SG,Day BW

更新日期：1999-01-01 00:00:00

abstract：:It is believed that chemotherapeutic agents can enhance the malignancy of treated cancer cells in clinical situations, which is a major problem for chemotherapy. However, the underlying molecular mechanisms are still not fully understood. Here, we demonstrated that chemotherapy up-regulates the levels of spermatogenic...

journal_title：Biochemical pharmacology

authors： Liu X,Han X,Wan X,He C,Wang Y,Mao A,Yu F,Zhou T,Feng L,Zhang P,Jin J,Ma X

更新日期：2018-10-01 00:00:00

abstract：:For almost 10 years, Nod2 has been known as a cytosolic innate receptor able to sense peptidoglycan from Gram-positive and -negative bacteria and to trigger RIP2- and NF-κB-mediated pro-inflammatory and antibacterial response. Mutations in the gene encoding Nod2 in humans have been associated with Crohn's disease (CD)...

journal_title：Biochemical pharmacology

authors： Lecat A,Piette J,Legrand-Poels S

更新日期：2010-12-15 00:00:00

abstract：:Clonidine, idazoxan, and related imidazoline adrenergic drugs bind to non-adrenergic sites in brain and several peripheral tissues. These sites, termed imidazoline receptors, appear to exist in two major subclasses, I1 sites labeled by clonidine and I2 sites labeled by idazoxan. In this study, we investigated whether ...

journal_title：Biochemical pharmacology

authors： Regunathan S,Nassir Y,Sundaram K,Vaughan ED Jr,Reis DJ,Felsen D

更新日期：1996-02-23 00:00:00

abstract：:During receptor-mediated endocytosis (RME), extracellular molecules are internalized after being recognized and bound to specific cell surface receptors. In previous studies of the asialoglycoprotein receptor (ASGPR) in rats, we showed that ethanol impairs RME at multiple ASGPR sites. Ethanol administration has been s...

journal_title：Biochemical pharmacology

authors： Dalton SR,Wiegert RL,Baldwin CR,Kassel KM,Casey CA

更新日期：2003-02-15 00:00:00

abstract：:Metabolism of the synthetic steroid 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) occurs in the dedifferentiated S-H56-125 variant of Reuber hepatoma. Considering that rat liver cytochrome P450 (P450) monooxygenases are engaged in different oxidative steps of the metab...

journal_title：Biochemical pharmacology

authors： Chasserot-Golaz S,Beck G,Venetianer A

更新日期：1993-12-03 00:00:00

abstract：:The neuroprotective effects of adenosine are well-recognized. Recently, propentofylline, a xanthine derivative, has been shown to increase extracellular concentrations of adenosine in ischemic brain and to limit the extent of neuronal damage in experimental models of cerebral ischemia. Since the concentration of adeno...

journal_title：Biochemical pharmacology

authors： Parkinson FE,Paterson AR,Young JD,Cass CE

更新日期：1993-09-01 00:00:00

abstract：:Escape from the proper control of the cell cycle by up-regulation of cyclins or aberrant activation of cyclin-dependent kinases (CDKs) as well as by inactivation of cellular inhibitors of CDKs (CKI) leads to malignant transformation. Loss of cellular CKIs in cancers provided a rationale for development of pharmacologi...

journal_title：Biochemical pharmacology

authors： Wesierska-Gadek J,Hajek SB,Sarg B,Wandl S,Walzi E,Lindner H

更新日期：2008-12-01 00:00:00

abstract：:Glipentide, a second generation sulfonylurea, raised the cellular concentration of fructose 2,6-bisphosphate in isolated rat hepatocytes. Parallel to accumulating this regulatory metabolite, glipentide inhibited basal gluconeogenesis and increased the rate of L-lactate production, as well as the metabolic flux through...

journal_title：Biochemical pharmacology

authors： López-Alarcón L,Berbil-Bautista PR,Guijarro C,Felíu JE

更新日期：1988-08-15 00:00:00

abstract：:Incubation of rat peritoneal mast cells with hydrogen peroxide results in a marked release of histamine. Maximal release is observed with 0.05-0.1 mM H(2)O(2), but higher concentrations of H(2)O(2) instead suppresses the release. Histamine release starts after about 2 min of lag time and reaches a plateau in about 10 ...

journal_title：Biochemical pharmacology

authors： Ohmori H,Yamamoto I,Akagi M,Tasaka K

更新日期：1980-03-01 00:00:00

abstract：:We report here studies on the regulation of the metabolism of adenosine 3',5'-monophosphate (cAMP) in established and primary cultures of rat pulmonary microvascular endothelial cells (RPMVEC). Inhibition by rolipram, a selective inhibitor of cAMP phosphodiesterase (PDE) of the PDE4 gene family, was required to achiev...

journal_title：Biochemical pharmacology

authors： Thompson WJ,Ashikaga T,Kelly JJ,Liu L,Zhu B,Vemavarapu L,Strada SJ

更新日期：2002-02-15 00:00:00

abstract：:The uptake of iron by the liver and cerebellum was measured in rats using [59Fe]transferrin. An acute ethanol load (50 mmol/kg body wt., i.p.) elicited a significant increase in the hepatic and cerebellar non-heme iron concentration. The uptake of 59Fe by the liver and the cerebellum was significantly greater in the e...

journal_title：Biochemical pharmacology

authors： Rouach H,Houze P,Gentil M,Orfanelli MT,Nordmann R

更新日期：1994-05-18 00:00:00

abstract：:N-[5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl]-L-glutamic acid (ZD1694) is a folate-based thymidylate synthase (TS; EC 2.1.1.45) inhibitor. Metabolism to higher chain length polyglutamates is essential for its optimal cytotoxic effect. A ZD1694-resistant (300-fold) human ileocecal...

journal_title：Biochemical pharmacology

authors： Lu K,Yin MB,McGuire JJ,Bonmassar E,Rustum YM

更新日期：1995-07-31 00:00:00