Abstract：
:Glipentide, a second generation sulfonylurea, raised the cellular concentration of fructose 2,6-bisphosphate in isolated rat hepatocytes. Parallel to accumulating this regulatory metabolite, glipentide inhibited basal gluconeogenesis and increased the rate of L-lactate production, as well as the metabolic flux through the 6-phosphofructo 1-kinase reaction. Tolbutamide elicited similar metabolic effects to those reported for glipentide, although the latter sulfonylurea was about 10 times more potent. The biochemical mechanism by which sulfonylureas promote the accumulation of fructose 2,6-bisphosphate in hepatocytes seems to be related to a significant increase of the hexose 6-phosphate pool (glucose 6-phosphate plus fructose 6-phosphate), together with the activation of 6-phosphofructo 2-kinase and inactivation of fructose 2,6-bisphosphatase, enzyme activities responsible, respectively, for the synthesis and degradation of fructose 2,6-bisphosphate.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
López-Alarcón L,Berbil-Bautista PR,Guijarro C,Felíu JEdoi
10.1016/0006-2952(88)90317-6subject
Has Abstractpub_date
1988-08-15 00:00:00pages
3177-82issue
16eissn
0006-2952issn
1873-2968pii
0006-2952(88)90317-6journal_volume
37pub_type
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