Fifty years of Biochemical Pharmacology: the discipline and the journal.

abstract：:Purified red blood cell cytosol is able to activate 2-aminofluorene (2AF) to N-hydroxy-2-aminofluorene. Apparent kinetic parameters are determined with and without methylene blue. The latter, which maintains haemoglobin in the reduced form and stimulates NADPH production, increases the affinity of the enzyme for the 2...

journal_title：Biochemical pharmacology

authors： Duverger-van Bogaert M,Wiame D,Stecca C

更新日期：1992-12-15 00:00:00

abstract：:We examined the effects of pyrazoloacridine (PZA), an investigational anticancer agent in clinical trials, on cytotoxicity, DNA synthesis, and DNA damage in MCF-7 human breast carcinoma cells. With PZA concentrations ranging from 0.5 to 50 microM for durations of 3-72 hr, cytotoxicity increased in proportion to the to...

journal_title：Biochemical pharmacology

authors： Grem JL,Politi PM,Berg SL,Benchekroun NM,Patel M,Balis FM,Sinha BK,Dahut W,Allegra CJ

更新日期：1996-06-28 00:00:00

abstract：:In this study we investigated whether NADH fluorescence levels changed in response to low or high rates of electrical stimulation in single ventricular myocytes isolated from rat and guinea-pig hearts, either during a single contraction or upon sustained electrical stimulation of cells. NADH levels were determined fro...

journal_title：Biochemical pharmacology

authors： Griffiths EJ,Lin H,Suleiman MS

更新日期：1998-07-15 00:00:00

abstract：:N-[(2'-Dimethylamino)ethyl]acridine-4-carboxamide (DACA) is a new anticancer agent currently undergoing clinical trials. The metabolism of DACA to acridone metabolites by aldehyde oxidase (AO) (EC 1.2.3.1) appears to play a major role in its elimination in human patients and rodents. The aim of this study was to compa...

journal_title：Biochemical pharmacology

authors： Schofield PC,Robertson IG,Paxton JW

更新日期：2000-01-15 00:00:00

abstract：:In order to elucidate the role of mitochondrial dysfunction in paracetamol-induced hepatotoxicity, the effects of paracetamol on the oxygen consumption and ATP content of the isolated perfused rat liver were correlated with parameters of hepatic viability and hepatotoxicity. Paracetamol at 5 g/L reduced the oxygen con...

journal_title：Biochemical pharmacology

authors： Strubelt O,Younes M

更新日期：1992-07-07 00:00:00

abstract：:Human leukemia K562 and HeLa cells were treated with daunomycin (DA) for 1-4 hr. With the indirect immunofluorescence technique, we observed that the nucleolar protein nucleophosmin/B23 (NPM) shifted its location from the nucleolus to the nucleoplasm (NPM-translocation). The degree of NPM-translocation was determined ...

journal_title：Biochemical pharmacology

authors： Chan PK,Chan FY

更新日期：1999-06-01 00:00:00

abstract：:Cytosolic sulfotransferases (SULTs), which mediate the conjugation of drugs with 3'-phosphoadenosine-5'-phosphosulfate, have been characterized in humans and cynomolgus monkeys. However, SULTs remain to be evaluated in common marmosets, a species of non-human primate often employed in drug metabolism and pharmacokinet...

journal_title：Biochemical pharmacology

authors： Uno Y,Uehara S,Murayama N,Shimizu M,Yamazaki H

更新日期：2020-10-01 00:00:00

abstract：:Nuclear factor-E2-related factor 2 (Nrf2) is a master transcription factor in antioxidant response, protecting against oxidative damage and various diseases. Previous studies suggest that Nrf2 is suppressed in fibrotic skin and Nrf2 agonists represent a therapeutic strategy, which is mainly attributed to Nrf2 function...

journal_title：Biochemical pharmacology

authors： Wu R,Zhang H,Zhao M,Li J,Hu Y,Fu J,Pi J,Wang H,Xu Y

更新日期：2020-04-01 00:00:00

abstract：:The binding affinity of ethanol for carbohydrates is unknown. Glycoconjugates are postulated to be sensitive targets of ethanol action. The glycogen content of muscle, liver, and brain is sensitive to ethanol. To explore whether carbohydrates as a class have a specific affinity to bind ethanol, we measured the binding...

journal_title：Biochemical pharmacology

authors： Channareddy S,Jose SS,Janes N

更新日期：1996-12-24 00:00:00

abstract：:The long-term effects of incubating freshly isolated, elicited guinea-pig peritoneal macrophages with the beta-adrenoceptor agonist isoprenaline and the selective inhibitor of phosphodiesterase (PDE) IV rolipram, on adenosine-3',5'-cyclic phosphate (cAMP)-specific PDE IV activity have been investigated. The level of c...

journal_title：Biochemical pharmacology

authors： Kochetkova M,Burns FM,Souness JE

更新日期：1995-12-22 00:00:00

abstract：:The cytotoxicity anti-tumour intercalating agents such as the anthraquinone mitoxantrone is thought to relate to DNA binding and the trapping of DNA topoisomerase II complexes on cellular DNA. We have studied the uptake, nuclear location, DNA binding mode and DNA damaging capacity of mitoxantrone in a small cell lung ...

journal_title：Biochemical pharmacology

authors： Smith PJ,Morgan SA,Fox ME,Watson JV

更新日期：1990-11-01 00:00:00

abstract：:The sensitivity to barbiturates of [3H]GABA binding to synaptosomal membrane fractions from rat cortex has been examined. We show that a range of anaesthetic/sedative barbiturates enhance GABA binding in the presence of chloride or other ions that interact with the associated ionophore. Furthermore, picrotoxinin and t...

journal_title：Biochemical pharmacology

authors： Whittle SR,Turner AJ

更新日期：1982-09-15 00:00:00

abstract：:Membrane damage caused by phospholipase A action is thought to be an important factor in ischemic myocardial injury. Propranolol has been shown previously to have beneficial effects in both animal experiments and clinical trials, and it has membrane-stabilizing properties in vitro. To investigate the possibility that ...

journal_title：Biochemical pharmacology

authors： Trotz M,Jellison EJ,Hostetler KY

更新日期：1987-12-15 00:00:00

abstract：:The effect of deferoxamine on nucleotide metabolism in HL-60 leukemic cells was studied to explore the mechanism of its antiproliferation activity. It was found that in intact cells deferoxamine markedly inhibited the ribonucleotide reduction and incorporation of bases (adenine, hypoxanthine), ribonucleosides (inosine...

journal_title：Biochemical pharmacology

authors： Barankiewicz J,Cohen A

更新日期：1987-07-15 00:00:00

abstract：:Selective removal of sialic acid from isolated guinea pig left atrial strips and rabbit thoracic aortic ring segments was performed by neuraminidase prepared from Clostridium perfringens and was controlled electron microscopically. Preincubation of these organs (2 units/mL; 2 hr) resulted in enzyme mediated hydrolysis...

journal_title：Biochemical pharmacology

authors： Werner G,Addicks K,Fricke U,Klaus W,Sarram M,Gielen W

更新日期：1991-12-11 00:00:00

abstract：:Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Here we studied the mechanisms of action of Chl...

journal_title：Biochemical pharmacology

authors： Rakshit S,Mandal L,Pal BC,Bagchi J,Biswas N,Chaudhuri J,Chowdhury AA,Manna A,Chaudhuri U,Konar A,Mukherjee T,Jaisankar P,Bandyopadhyay S

更新日期：2010-12-01 00:00:00

abstract：:Tumor cells proliferate under conditions of oxidative stress. A novel therapeutic approach would be to enhance the cellular effects of the reactive oxygen species formed under these conditions by supplementation with a redox catalyst. This provides a means to target and specifically destroy cancer cells via oxidation ...

journal_title：Biochemical pharmacology

authors： Giles NM,Giles GI,Holley JE,Gutowski NJ,Jacob C

更新日期：2003-11-15 00:00:00

abstract：:Auranofin (AF) is a newly introduced oral gold compound having antirheumatic properties, and its efficacy in the treatment of bronchial asthma is now under investigation. In this study, we examined the effects of AF on leukotriene (LT) formation by human polymorphonuclear leukocytes (PMNs) stimulated with the calcium ...

journal_title：Biochemical pharmacology

authors： Honda Z,Iizasa T,Morita Y,Matsuta K,Nishida Y,Miyamoto T

更新日期：1987-05-01 00:00:00

abstract：:Zinc protoporphyrin (ZnPP), a known inhibitor of heme oxygenase-1 (HO-1), has been reported to have anticancer activity in both in vitro and in vivo model systems. While the mechanisms of ZnPP's anticancer activity remain to be elucidated, it is generally believed that ZnPP suppresses tumor growth through inhibition o...

journal_title：Biochemical pharmacology

authors： Wang S,Avery JE,Hannafon BN,Lind SE,Ding WQ

更新日期：2013-06-01 00:00:00

abstract：:Certain anticonvulsant drugs require N-acetylation as a major route of metabolic clearance. Single point mutations of the polymorphic N-acetyltransferase gene (pNAT) are the primary cause for impaired drug acetylation. Pharmacokinetic parameters are altered in slow acetylator phenotypes and this may compromise drug sa...

journal_title：Biochemical pharmacology

authors： Borlak JT,Harsany V,Schneble H,Haegele KD

更新日期：1994-11-01 00:00:00

abstract：:OSI-7836 (4'-thio-araC, T-araC) is a nucleoside analogue that shows efficacy against solid tumor xenograft models. We examined how the triphosphates of OSI-7836 (T-araCTP), cytarabine (araCTP), and gemcitabine (dFdCTP) affected the initiation of new DNA strands by the pol alpha primase complex. Whereas dFdCTP very wea...

journal_title：Biochemical pharmacology

authors： Richardson KA,Vega TP,Richardson FC,Moore CL,Rohloff JC,Tomkinson B,Bendele RA,Kuchta RD

更新日期：2004-12-15 00:00:00

abstract：:Cyclic AMP (cAMP) and cyclic GMP (cGMP) are two second messengers that have been proposed to act as a dualistic system in biological regulation. To determine if cGMP plays a role in the mediation of circadian rhythmicity of the adenylate cyclase (AC)-cAMP-phosphodiesterase (PDE) system in the achlorophyllous ZC mutant...

journal_title：Biochemical pharmacology

authors： Tong J,Edmunds LN Jr

更新日期：1993-05-25 00:00:00

abstract：:Ectonucleotidases are key for purinergic signaling. They control the duration of activity of purinergic receptor agonists. At the same time, they produce hydrolysis products as additional ligands of purinergic receptors. Due to the considerable diversity of enzymes, purinergic receptor ligands and purinergic receptors...

journal_title：Biochemical pharmacology

authors： Zimmermann H

更新日期：2020-11-06 00:00:00

abstract：:A series of isoquinolines, N-methyl-1,2-dihydroisoquinolines, N-methyl-1,2,3,4-tetrahydroisoquinolines, 1,2,3,4-tetrahydroisoquinolines, and N-methylisoquinolinium ions were tested as inhibitors of monoamine oxidases A and B. All compounds were found to act as reversible and time-independent MAO inhibitors, often with...

journal_title：Biochemical pharmacology

authors： Thull U,Kneubühler S,Gaillard P,Carrupt PA,Testa B,Altomare C,Carotti A,Jenner P,McNaught KS

更新日期：1995-09-07 00:00:00

abstract：:The effect of naturally occurring hydroxystilbene, 3,3',4,5-tetrahydroxystilbene (piceatanol), and its derivatives on gastric H+, K(+)-ATPase was studied. Piceatanol inhibited H+, K(+)-ATPase in a dose-dependent manner. The 50% inhibition value was 4.3 x 10(-6) M. It was found from the kinetic study that the inhibitio...

journal_title：Biochemical pharmacology

authors： Murakami S,Arai I,Muramatsu M,Otomo S,Baba K,Kido T,Kozawa M

更新日期：1992-11-17 00:00:00

abstract：:We have investigated a series of novel 4-aminoquinoline analogues related to amodiaquine, that possess side chain modifications designed to influence both drug pKa and lipophilicity. These compounds have been used to determine the influence of physicochemical properties on antimalarial activity against, and accumulati...

journal_title：Biochemical pharmacology

authors： Hawley SR,Bray PG,O'Neill PM,Park BK,Ward SA

更新日期：1996-09-13 00:00:00

abstract：:Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident wi...

journal_title：Biochemical pharmacology

authors： Combes B,Backof B

更新日期：1982-08-15 00:00:00

abstract：:The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer. Recent work has led to the realization that p53 lies at the hub of a very complex network of signaling pathways, which integ...

journal_title：Biochemical pharmacology

authors： Oren M,Damalas A,Gottlieb T,Michael D,Taplick J,Leal JF,Maya R,Moas M,Seger R,Taya Y,Ben-Ze'ev A

更新日期：2002-09-01 00:00:00

abstract：:Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I cli...

journal_title：Biochemical pharmacology

authors： Lind S,Sundqvist M,Holmdahl R,Dahlgren C,Forsman H,Olofsson P

更新日期：2019-08-01 00:00:00

abstract：:Cellular glutathione concentrations in primary cultures of chick embryo hepatocytes were 15.3 +/- 5.3 nmoles/mg protein (mean +/- S.D.) and remained stable for up to 3 days in culture. The presence of insulin was not essential for the maintenance of glutathione concentrations. Induction of cytochrome P-450 by phenobar...

journal_title：Biochemical pharmacology

authors： Shedlofsky SI,Sinclair PR,Sinclair JF,Bonkovsky HL

更新日期：1984-05-01 00:00:00