Hydroxychavicol from Piper betle induces apoptosis, cell cycle arrest, and inhibits epithelial-mesenchymal transition in pancreatic cancer cells.

abstract：:Lactate, once considered a metabolic dead-end, has been recently proposed to support neuron bioenergetics. To better understand how lactate specifically influences cell energy metabolism, we studied the effects of lactate supplementation on SH-SY5Y human neuroblastoma cell bioenergetic fluxes. Lactate supplementation ...

journal_title：Biochemical pharmacology

authors： E L,Swerdlow RH

更新日期：2016-01-01 00:00:00

abstract：:SARM is the fifth and most conserved member of the Toll/Il-1 Receptor (TIR) adaptor family. However, unlike the other TIR adaptors, MyD88, Mal, TRIF and TRAM, SARM does not participate in transducing signals downstream of TLRs. By contrast SARM inhibits TLR signalling by interacting with the adaptors TRIF and MyD88. I...

journal_title：Biochemical pharmacology

authors： Carty M,Bowie AG

更新日期：2019-03-01 00:00:00

abstract：:Low molecular weight cadmium-binding proteins were studed in lung tissue from rabbits exposed to aerosols of CdCl2. Lungs obtained from animals exposed by inhalation to aerosols of 800 or 1600 micrograms/m3 CdCl2 for 2-hr periods/day, every other day for a 5-day period, were found to contain at least three low molecul...

journal_title：Biochemical pharmacology

authors： Post CT,Squibb KS,Fowler BA,Gardner DE,Illing J,Hook GE

更新日期：1982-09-15 00:00:00

abstract：:P-glycoprotein (P-gp) plays critical roles in mediating the cytotoxicity of many drugs that are P-gp substrates. Previously, we reported that P-glycoprotein (P-gp) is the foremost efflux transporter of deoxynivalenol (DON), which is one of the most abundant mycotoxins. However, whether DON changes the expression of P-...

journal_title：Biochemical pharmacology

authors： Li X,Mu P,Qiao H,Wen J,Deng Y

更新日期：2018-10-01 00:00:00

abstract：:We have studied the effects of TPA on the metabolism of porcine thyroid cells cultured for 1-4 days in the absence (control cells) and in the presence of 0.1 mU/ml TSH (TSH cells). The phospholipid turnover, evaluated after a 2 hr incorporation of 32P-phosphate into phospholipids, is markedly modified by the presence ...

journal_title：Biochemical pharmacology

authors： Haye B,Aublin JL,Champion S,Lambert B,Jacquemin C

更新日期：1985-11-01 00:00:00

abstract：:Nitric oxide is an important mediator of excessive cell growth and inflammation associated with many epidermal proliferative disorders. It is a highly reactive oxidant generated in keratinocytes and macrophages via the inducible form of the enzyme nitric oxide synthase (NOS2). In the present studies, we examined the e...

journal_title：Biochemical pharmacology

authors： Sur R,Heck DE,Mariano TM,Jin Y,Murphy WJ,Laskin JD

更新日期：2002-11-15 00:00:00

abstract：:The effects of 3-monoalkyl- and 3,5-dialkyl-substitution on the cytotoxicity of paracetamol (PAR) in rat hepatocytes was studied. PAR is known to be bioactivated by the hepatic microsomal cytochrome P-450 containing a mixed-function oxidase system presumably to N-acetyl-para-benzoquinone imine (NAPQI), a reactive meta...

journal_title：Biochemical pharmacology

authors： Van De Straat R,De Vries J,Kulkens T,Debets AJ,Vermeulen NP

更新日期：1986-11-01 00:00:00

abstract：:Metabolism of the synthetic steroid 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) occurs in the dedifferentiated S-H56-125 variant of Reuber hepatoma. Considering that rat liver cytochrome P450 (P450) monooxygenases are engaged in different oxidative steps of the metab...

journal_title：Biochemical pharmacology

authors： Chasserot-Golaz S,Beck G,Venetianer A

更新日期：1993-12-03 00:00:00

abstract：:Restoration of dysregulated bone homeostasis is a therapeutic goal in many diseases including osteoporosis, rheumatoid arthritis and metastatic cancer. The molecular pathways regulating bone remodeling are major therapeutic targets, and studies continue to reveal endogenous factors that may be pathologically up- or do...

journal_title：Biochemical pharmacology

authors： Abraham AK,Ramanathan M,Weinstock-Guttman B,Mager DE

更新日期：2009-06-15 00:00:00

abstract：:The effect of lowering intracellular glutathione (GSH) concentrations on the toxicity of alkylating agents, and RNA synthesis inhibitor and topoisomerase 1 and 2 inhibitors to a number of human leukaemic cell lines were evaluated. By using the GSH synthesis inhibitor DL-buthionine-(S,R)-sulfoximine (BSO), GSH levels w...

journal_title：Biochemical pharmacology

authors： Fernandes RS,Cotter TG

更新日期：1994-08-17 00:00:00

abstract：:Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA modifications in the cytoplasm. However, the biological processes regulated by Elongator in human cells only start to be elucid...

journal_title：Biochemical pharmacology

authors： Cornez I,Creppe C,Gillard M,Hennuy B,Chapelle JP,Dejardin E,Merville MP,Close P,Chariot A

更新日期：2008-06-01 00:00:00

abstract：:Bufuralol hydroxylation activities of liver microsomal cytochrome P450 (P450) enzymes were studied in the rat; the reaction has been used widely in determining levels of liver microsomal P450 2D6, which shows debrisoquine-type genetic polymorphism in humans. Liver microsomes catalyzed the conversion of bufuralol to 1'...

journal_title：Biochemical pharmacology

authors： Mimura M,Yamazaki H,Sugahara C,Hiroi T,Funae Y,Shimada T

更新日期：1994-06-01 00:00:00

abstract：:The regulation of tissue transglutaminase (TG2) activity by the GPCR family is poorly understood. In this study, we investigated the modulation of TG2 activity by the A1 adenosine receptor in cardiomyocyte-like H9c2 cells. H9c2 cells were lysed following stimulation with the A1 adenosine receptor agonist N(6)-cyclopen...

journal_title：Biochemical pharmacology

authors： Vyas FS,Hargreaves AJ,Bonner PL,Boocock DJ,Coveney C,Dickenson JM

更新日期：2016-05-01 00:00:00

abstract：:In the present study the inability of 1,4-benzoquinone to support NADPH-cytochrome reductase catalysed redox cycling was investigated. The results obtained demonstrate that NADPH-cytochrome reductase is able to initiate a rapid two-electron reduction of 1,4-benzoquinone resulting in formation of the hydroquinone. The ...

journal_title：Biochemical pharmacology

authors： Boersma MG,Balvers WG,Boeren S,Vervoort J,Rietjens IM

更新日期：1994-06-01 00:00:00

abstract：:Alterations in heme biosynthetic and degradative capabilities and in the activities of several heme-containing enzymes were examined in hepatic tissues of streptozotocin (STZ)-diabetic female Sprague-Dawley rats. Activities were measured 10, 30 and 90 days following the administration of STZ (65 mg/kg, i.v.). The acti...

journal_title：Biochemical pharmacology

authors： Bitar M,Weiner M

更新日期：1983-06-15 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ) is a novel redox cofactor recently found in human milk. It has been reported to function as an essential nutrient, antioxidant and redox modulator in cell culture experiments and in animal models of human diseases. As mitochondria are particularly susceptible to oxidative damage we studi...

journal_title：Biochemical pharmacology

authors： He K,Nukada H,Urakami T,Murphy MP

更新日期：2003-01-01 00:00:00

abstract：:The formyl peptide receptor (FPR) gene family has a complex evolutionary history and comprises eight murine members but only three human representatives. To enable translation of results obtained in mouse models of human diseases, more comprehensive knowledge of the pharmacological similarities/differences between the...

journal_title：Biochemical pharmacology

authors： Skovbakke SL,Winther M,Gabl M,Holdfeldt A,Linden S,Wang JM,Dahlgren C,Franzyk H,Forsman H

更新日期：2016-11-01 00:00:00

abstract：:Chemokines and their receptors play fundamental roles in many physiological and pathological processes such as leukocyte trafficking, inflammation, cancer and HIV-1 infection. Chemokine-receptor interactions are particularly intricate and therefore require precise orchestration. The flexible N-terminal domain of human...

journal_title：Biochemical pharmacology

authors： Szpakowska M,Fievez V,Arumugan K,van Nuland N,Schmit JC,Chevigné A

更新日期：2012-11-15 00:00:00

abstract：:Treatment of human, peripheral blood neutrophils with gamma-interferon both "primed" their ability to generate reactive oxidants and increased their rate of protein synthesis. This increased rate of protein synthesis was greatest 60 min after the addition of 100 U/ml gamma-interferon and was not due to an increased in...

journal_title：Biochemical pharmacology

authors： Humphreys JM,Hughes V,Edwards SW

更新日期：1989-04-15 00:00:00

abstract：:Human recombinant superoxide dismutase (SOD) was modified into a mannosylated form (Man-SOD), and its cellular uptake and inhibitory effect on superoxide anion release were studied in vitro, using cultured mouse peritoneal macrophages. [111In]Man-SOD was taken up by the macrophages to a great extent, whereas no signif...

journal_title：Biochemical pharmacology

authors： Takakura Y,Masuda S,Tokuda H,Nishikawa M,Hashida M

更新日期：1994-03-02 00:00:00

abstract：:Petrosaspongiolide M (PT) is a potent secretory phospholipase A(2) inhibitor and anti-inflammatory agent. This marine metabolite reduced the production of nitrite, prostaglandin E(2), and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan. These effects were also observed in mouse peritoneal macr...

journal_title：Biochemical pharmacology

authors： Posadas I,Terencio MC,Randazzo A,Gomez-Paloma L,Payá M,Alcaraz MJ

更新日期：2003-03-01 00:00:00

abstract：:The pharmacological properties of the human D2L (long isoform) and rat D3 dopamine receptors in functional assays were examined. A range of dopamine agonists were assessed for their ability to inhibit adenosine 3'5'-cyclic monophosphate (cAMP) accumulation via the two receptors expressed stably in Chinese hamster ovar...

journal_title：Biochemical pharmacology

authors： Hall DA,Strange PG

更新日期：1999-07-15 00:00:00

abstract：:Chronic blockade of nitric oxide (NO) synthesis attenuates the eosinophil infiltration into airways of allergic rats. This study was designed to investigate whether the inhibition of eosinophil influx to the lung of allergic rats reflects modifications in the pattern of cell mobilization from the bone marrow to periph...

journal_title：Biochemical pharmacology

authors： Ferreira HH,Costa RA,Jacheta JM,Martins AR,Medeiros MV,Macedo-Soares MF,De Luca IM,Antunes E,De Nucci G

更新日期：2004-08-15 00:00:00

abstract：:Tumor cells are more sensitive to methionine restriction than normal tissues, a phenomenon known as methionine auxotrophy. Previous studies showed that 5-fluorouracil and methionine restriction act synergistically against a variety of tumors. The purpose of the current studies was to determine the molecular mechanism(...

journal_title：Biochemical pharmacology

authors： Lu S,Chen GL,Ren C,Kwabi-Addo B,Epner DE

更新日期：2003-09-01 00:00:00

abstract：:The chiral inversion properties of 4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (KE-748), an active metabolite of 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298), were compared with those of ibuprofen in rats. After administration of R(-)-[2 alpha-2H]KE-748, S(+)-KE-748 was present in the...

journal_title：Biochemical pharmacology

authors： Yoshida H,Kohno Y,Endo H,Yamaguchi J,Fukushima K,Suwa T,Hayashi M

更新日期：1997-01-24 00:00:00

abstract：:Alcohol-fed hamsters were used to study the mechanism by which acetaminophen initiates hepatotoxicity. Animals maintained on an ethanol-containing diet (Group B) exhibited an increased mortality rate after administration of acetaminophen (400 mg/kg) as compared to control hamsters (Group A). However, in those animals ...

journal_title：Biochemical pharmacology

authors： Rosen GM,Singletary WV Jr,Rauckman EJ,Killenberg PG

更新日期：1983-07-01 00:00:00

abstract：:Ibuprofen and related 2-arylpropanoic acid (2-APA) drugs are often given as a racemic mixture and the R-enantiomers undergo activation in vivo by metabolic chiral inversion. The chiral inversion pathway consists of conversion of the drug to the coenzyme A ester (by an acyl-CoA synthetase) followed by chiral inversion ...

journal_title：Biochemical pharmacology

authors： Qu X,Allan A,Chui G,Hutchings TJ,Jiao P,Johnson L,Leung WY,Li PK,Steel GR,Thompson AS,Threadgill MD,Woodman TJ,Lloyd MD

更新日期：2013-12-01 00:00:00

abstract：:Despite the substantial progress made in understanding initiation expression of the MOR gene in lymphocytes, the signal pathway associated with MOR gene transcription remains to be better defined. As the phosphatidylinositol 3-kinase (PI3K)/AKT pathway can mediate diverse biological responses and is crucial for optima...

journal_title：Biochemical pharmacology

authors： Liu H,Li H,Guo L,Li M,Li C,Wang S,Jiang W,Liu X,McNutt MA,Li G

更新日期：2010-02-01 00:00:00

abstract：:The metabolism of 3-phenoxybenzoic acid (3PBA) in the form of triacylglycerol conjugates was compared with that of non-esterified 3PBA. Three radiolabeled triacylglycerols (rac-1-(3-phenoxy-[ring-14C]-benzoyl)-2,3-dipalmitoylglycerol (1(3PBA)DPG), sn-2-(3-phenoxy-[ring-14C]benzoyl)-1,3-dipalmitoylglycerol (2(3PBA)DPG)...

journal_title：Biochemical pharmacology

authors： Haselden JN,Dodds PF,Hutson DH

更新日期：1998-12-15 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone produced by gastrointestinal tract in response to food ingestion. GLP-1 plays a very important role in the glucose homeostasis by stimulating glucose-dependent insulin secretion, inhibiting glucagon secretion, inhibiting gastric emptying, reducing appetite an...

journal_title：Biochemical pharmacology

authors： Torres G,Morales PE,García-Miguel M,Norambuena-Soto I,Cartes-Saavedra B,Vidal-Peña G,Moncada-Ruff D,Sanhueza-Olivares F,San Martín A,Chiong M

更新日期：2016-03-15 00:00:00