Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism.

abstract：:The in-vivo effect of dehydroepiandrosterone (DHEA) on hepatic enzyme activities of rats, mice, hamsters and guinea pigs was investigated. After DHEA treatment (300 mg/kg body weight, per os, 14 days), the activities of peroxisomal beta-oxidation, catalase, carnitine acetyltransferase, carnitine palmitoyltransferase, ...

journal_title：Biochemical pharmacology

authors： Sakuma M,Yamada J,Suga T

更新日期：1992-03-17 00:00:00

abstract：:Eleven naturally occurring flavonoids representing five different chemical classes were studied for their effects on human basophil histamine release triggered by six different stimuli. The flavonoids included flavone, quercetin, taxifolin, chalcone, apigenin, fisetin, rutin, phloretin, tangeretin, hesperetin, and nar...

journal_title：Biochemical pharmacology

authors： Middleton E Jr,Drzewiecki G

更新日期：1984-11-01 00:00:00

abstract：:Cystic fibrosis (CF) is a common lethal genetic disease caused by autosomal recessive mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that belongs to the ATP-Binding Cassette (ABC) family of transporters. The class III CF mutations G551D and G1349D are located within the "s...

journal_title：Biochemical pharmacology

authors： Melin P,Thoreau V,Norez C,Bilan F,Kitzis A,Becq F

更新日期：2004-06-15 00:00:00

abstract：:Change in the membrane fluidity of human erythrocytes on transformation to stomatocytes was observed by ESR spectroscopy using 12-doxyl stearic acid or its methyl ester as a probe. When the transformation to stomatocytes was induced by four qualitatively different methods, i.e. (a) addition of cationic amphiphilic age...

journal_title：Biochemical pharmacology

authors： Noji S,Takahashi T,Kon H

更新日期：1982-10-15 00:00:00

abstract：:The capacity of G protein-coupled receptors to modulate mechanistic target of rapamycin (mTOR) activity is a newly emerging paradigm with the potential to link cell surface receptors with cell survival. Cardiomyocyte viability is linked to signalling pathways involving Akt and mTOR, as well as increased glucose uptake...

journal_title：Biochemical pharmacology

authors： Sato M,Evans BA,Sandström AL,Chia LY,Mukaida S,Thai BS,Nguyen A,Lim L,Tan CYR,Baltos JA,White PJ,May LT,Hutchinson DS,Summers RJ,Bengtsson T

更新日期：2018-02-01 00:00:00

abstract：:Nephrotoxicity due to renal proximal tubule accumulation of aminoglycoside (AG) antibiotics, such as gentamicin, represents a major clinical problem. Receptor-mediated endocytosis via the multi-ligand receptor megalin is thought to be a key mechanism in the cellular uptake of AGs and nephrotoxicity. This process can b...

journal_title：Biochemical pharmacology

authors： Antoine DJ,Srivastava A,Pirmohamed M,Park BK

更新日期：2010-02-15 00:00:00

abstract：:ABT-770 [(S)-N-[1-[[4'-trifluoromethoxy-[1,1'-biphenyl]-4-yl]oxy]methyl-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide], a matrix metalloproteinase inhibitor (MMPI), produced generalized phospholipidosis in rats. Phospholipid accumulation was accompanied by retention of drug-related material and ...

journal_title：Biochemical pharmacology

authors： Gum RJ,Hickman D,Fagerland JA,Heindel MA,Gagne GD,Schmidt JM,Michaelides MR,Davidsen SK,Ulrich RG

更新日期：2001-12-15 00:00:00

abstract：:It has been hypothesized that oxidative modification of low density lipoprotein plays a key role in the pathogenesis of atherosclerosis. In order to elucidate the role of lipid oxidation and its inhibition in vivo, apolipoprotein E and alpha-tocopherol (alphaT) transfer protein double knockout (ApoE(-/-)alpha-TTP(-/-)...

journal_title：Biochemical pharmacology

authors： Yoshida Y,Hayakawa M,Itoh N,Habuchi Y,Inoue R,Chen ZH,Cao J,Cynshi O,Jishage K,Niki E

更新日期：2007-10-01 00:00:00

abstract：:The sensitivity to barbiturates of [3H]GABA binding to synaptosomal membrane fractions from rat cortex has been examined. We show that a range of anaesthetic/sedative barbiturates enhance GABA binding in the presence of chloride or other ions that interact with the associated ionophore. Furthermore, picrotoxinin and t...

journal_title：Biochemical pharmacology

authors： Whittle SR,Turner AJ

更新日期：1982-09-15 00:00:00

abstract：:5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3). PTAU has inhibition constant (K(is)) values of 248 and 353 nM towards UrdPase from mouse and human livers, respectively. PTAU was ...

journal_title：Biochemical pharmacology

authors： el Kouni MH,Goudgaon NM,Rafeeq M,Al Safarjalani ON,Schinazi RF,Naguib FN

更新日期：2000-09-15 00:00:00

abstract：:The addition of atrial natriuretic peptide (ANP) to isolated human adipocytes in primary culture from very obese individuals resulted in an inhibition of leptin release after a 24- or 48-hr incubation. There was also an inhibition of leptin release by isoproterenol (ISO) that was partially reversed by insulin, whereas...

journal_title：Biochemical pharmacology

authors： Fain JN,Kanu A,Bahouth SW,Cowan GS,Lloyd Hiler M

更新日期：2003-06-01 00:00:00

abstract：:Endosulfan (E) is an organochloric insecticide, which is quickly metabolized and eliminated from the body system. Toxic effects of E and its metabolites have been reported. The influence of E and its metabolites, viz. endosulfan sulfate (ES), endosulfan diol (ED) and endosulfan lactone (EL), has been examined on rat l...

journal_title：Biochemical pharmacology

authors： Dubey RK,Beg MU,Singh J

更新日期：1984-11-01 00:00:00

abstract：:Oligodendrocytes and activated macrophages are involved in the immunopathology of demyelinating disease. In this study, we investigated the in vitro effect of dietary compounds, in particular flavonoids, on oxidative damage in OLN-93 oligodendrocytes and on nitric oxide (NO) production by NR8383 macrophages. Using a c...

journal_title：Biochemical pharmacology

authors： van Meeteren ME,Hendriks JJ,Dijkstra CD,van Tol EA

更新日期：2004-03-01 00:00:00

abstract：:Inflammation, especially chronic inflammation, is directly involvement in the pathogenesis of many diseases including cancer. An effective approach for managing inflammation is to employ chemicals to block activation of nuclear factor-κB (NF-κB), a key regulator for inflammatory processes. Piperlongumine (piplartine, ...

journal_title：Biochemical pharmacology

authors： Sun LD,Wang F,Dai F,Wang YH,Lin D,Zhou B

更新日期：2015-06-01 00:00:00

abstract：:The possibility of NQ12 (2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone) as a novel antithrombotic agent and its mode of action were investigated. The effects of NQ12 on platelet aggregation in human platelet-rich plasma in vitro, in rats ex vivo, and on murine pulmonary thrombosis in vivo, as well as t...

journal_title：Biochemical pharmacology

authors： Yuk DY,Ryu CK,Hong JT,Chung KH,Kang WS,Kim Y,Yoo HS,Lee MK,Lee CK,Yun YP

更新日期：2000-10-01 00:00:00

abstract：:The present study aimed to investigate endothelin-1 (ET-1) receptors in human and swine cardiomyocytes with binding studies using ET(A) and ET(B) selective receptor antagonists (BMS-182874 and BQ-788, respectively). Cell distribution of mRNA expression for ET(A) and ET(B) subtypes was investigated by in situ hybridiza...

journal_title：Biochemical pharmacology

authors： Modesti PA,Vanni S,Paniccia R,Perna A,Maccherini M,Lisi G,Sani G,Neri Serneri GG

更新日期：1999-07-15 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is believed to induce neurotoxicity by inhibiting mitochondrial oxidative metabolism, whereas acetyl-L-carnitine (ALC) facilitates this process by transporting fatty acids into mitochondria for beta oxidation. We investigated whether large doses of ALC given by gavag...

journal_title：Biochemical pharmacology

authors： Harik SI,Hritz MA

更新日期：1993-05-25 00:00:00

abstract：:Angiogenesis has emerged as a critical process for tumour progression. Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. The most prominent and characterised pro-angiogenic pathway is th...

journal_title：Biochemical pharmacology

authors： Bridges EM,Harris AL

更新日期：2011-05-15 00:00:00

abstract：:A method to evaluate interactions between biologically active agents is presented. Synergism, zero interaction, and antagonism were easily detected with the three-dimensional approach proposed herein. This method is compatible with a checkerboard design to diagnose the interaction between agents and obviate the need t...

journal_title：Biochemical pharmacology

authors： Martinez-Irujo JJ,Villahermosa ML,Alberdi E,Santiago E

更新日期：1996-03-08 00:00:00

abstract：:The in vivo actions of two antimetabolites, acivicin (NSC-163501) and tiazofurin (NSC-286193), were examined on the enzymic programs of rat bone marrow. From the bone marrow of the femurs, 100,000 g supernatant fractions were prepared; enzymic activities were measured by isotopic assays, and cellularity was determined...

journal_title：Biochemical pharmacology

authors： Prajda N,Natsumeda Y,Ikegami T,Reardon MA,Szondy S,Hashimoto Y,Emrani J,Weber G

更新日期：1988-03-01 00:00:00

abstract：:The effect of varying the fatty acid composition of the lipid components of the diet on the activity of epoxide hydratase in the rat liver and intestinal mucosa has been studied. Feeding a 10% cod liver oil diet (containing 18% C20:5 and 11% C22:6) resulted in a 3-fold increase in epoxide hydratase activity in the liv...

journal_title：Biochemical pharmacology

authors： Gower JD,Sayer JW,Wills ED

更新日期：1986-06-15 00:00:00

abstract：:Tetraalkylammonium salts having n-propyl to n-amyl side chains inhibited rat liver sulfotransferase (ST) activities toward dehydroepiandrosterone and cortisol, but not ST activity toward 2-naphthol, whereas trialkylamines having ethyl to n-amyl side chains inhibited ST activity toward dehydroepiandrosterone, but not S...

journal_title：Biochemical pharmacology

authors： Matsui M,Takahashi M,Miwa Y,Motoyoshi Y,Homma H

更新日期：1995-03-01 00:00:00

abstract：:Cyclic guanosine 3'-5'-monophosphate (cGMP) has recently been shown to constitute a second messenger for Xenopus laevis melatonin Mel1c receptors. To verify whether cGMP levels are also modulated by mammalian melatonin receptors, we cloned the genes encoding the human Mel1a and Mel1b receptor subtypes and expressed th...

journal_title：Biochemical pharmacology

authors： Petit L,Lacroix I,de Coppet P,Strosberg AD,Jockers R

更新日期：1999-08-15 00:00:00

abstract：:Cisplatin is a potent chemotherapeutic drug widely used for the treatment of human cancer. However, its efficacy against hepatocellular carcinoma (HCC) is poor for reasons that remain unclear. We show here that prothymosin-alpha (PTMA) is overexpressed in HCC cell lines. Silencing PTMA using short-hairpin RNA sensitiz...

journal_title：Biochemical pharmacology

authors： Lin YT,Liu YC,Chao CC

更新日期：2016-12-15 00:00:00

abstract：:Sulphate conjugation was investigated using extracts of human foetal liver cells in culture. The three reactions which are involved in sulphate conjugation were measured singly or in combination: they are (i) the PAPS generation catalyzed by ATP-sulphurylase and adenosine 5'-phosphosulphate (APS)-kinase, (ii) the phen...

journal_title：Biochemical pharmacology

authors： Tan TM,Sit KH,Wong KP

更新日期：1988-12-15 00:00:00

abstract：:We have investigated a series of novel 4-aminoquinoline analogues related to amodiaquine, that possess side chain modifications designed to influence both drug pKa and lipophilicity. These compounds have been used to determine the influence of physicochemical properties on antimalarial activity against, and accumulati...

journal_title：Biochemical pharmacology

authors： Hawley SR,Bray PG,O'Neill PM,Park BK,Ward SA

更新日期：1996-09-13 00:00:00

abstract：:In assessing the biological effects of exposure to a complex chemical mixture, it is important to determine how the behavior of one compound may be influenced by the presence of other compounds in the mixture. In this study the effect of pre-exposure to an organic extract of diesel exhaust or to selected compounds in ...

journal_title：Biochemical pharmacology

authors： Howard AJ,Mitchell CE,Dutcher JS,Henderson TR,McClellan RO

更新日期：1986-07-01 00:00:00

abstract：:The aim of this study was to determine the culture conditions that could modulate the induction of apoptosis by all-trans retinoic acid (ATRA). Cell viability was evaluated by trypan blue test, differentiation by nitro blue tetrazolium test, and apoptosis by morphological analysis. ATRA induced apoptosis in HL60 cells...

journal_title：Biochemical pharmacology

authors： Carpentier Y,Mayer P,Bobichon H,Desoize B

更新日期：1998-01-15 00:00:00

abstract：:The effect of ethanol abuse on the lipid ordering of the human erythrocyte membranes was studied by steady-state and time-resolved fluorescence anisotropy measurements of DPH and its polar analogue TMA-DPH, which probe different membrane regions. Steady-state anisotropy values with DPH as a probe were slightly but sig...

journal_title：Biochemical pharmacology

authors： Beaugé F,Gallay J,Stibler H,Borg S

更新日期：1988-10-15 00:00:00

abstract：:Bupropion is a widely used antidepressant and smoking cessation aid and a strong inhibitor of CYP2D6 in vivo. Bupropion is administered as a racemic mixture of R- and S-bupropion and has stereoselective pharmacokinetics. Four primary metabolites of bupropion, threo- and erythro-hydrobupropion and R,R- and S,S-OH-bupro...

journal_title：Biochemical pharmacology

authors： Sager JE,Tripathy S,Price LS,Nath A,Chang J,Stephenson-Famy A,Isoherranen N

更新日期：2017-01-01 00:00:00