Abstract:
:We studied effects of graded concentrations of intragastric calcium on acid secretion, residual gastric volume, and serum gastrin and calcium levels. Intragastric titration was performed with solutions of isotonic mannitol or mannitol plus 2.5, 6, 16, 39, and 97 mM CaCl(2) in 10 normal and eight duodenal ulcer subjects. Acid secretion was significantly increased above control values by the two highest CaCl2 concentrations in normal subjects and by the three highest CaCl2 concentrations in ulcer subjects. Highest observed acid output to any concentration of CaCl2 was 55% of peak acid output to pentagastrin in normal subjects and 75% in ulcer subjects. Intragastric calcium also released gastrin; correlation between acid secretion and circulating gastrin was weak (r = 0.43, P less than 0.05). Serum calcium was slightly increased but did not correlate with acid secretion. Residual intragastric volume after both control and CaCl2 solutions was much less in ulcer than in normal subjects; calcium did not alter residual volumes.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Barclay G,Maxwell V,Grossman MI,Solomon TEdoi
10.1007/BF02430525subject
Has Abstractpub_date
1983-05-01 00:00:00pages
385-91issue
5eissn
0163-2116issn
1573-2568journal_volume
28pub_type
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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