Survival of critically ill patients hospitalized in and out of intensive care.

Abstract:

OBJECTIVE:A lack of intensive care units beds in Israel results in critically ill patients being treated outside of the intensive care unit. The survival of such patients is largely unknown. The present study's objective was to screen entire hospitals for newly deteriorated patients and compare their survival in and out of the intensive care unit. DESIGN:A priori developed intensive care unit admission criteria were used to screen, during 2 wks, the patient population for eligible incident patients. A screening team visited every hospital ward of five acute care hospitals daily. Eligible patients were identified among new admissions in the emergency department and among hospitalized patients who acutely deteriorated. Patients were followed for 30 days for mortality regardless of discharge. SETTING:Five acute care hospitals. PATIENTS:A total of 749 newly deteriorated patients. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Crude survival of patients in and out of the intensive care unit was compared by Kaplan-Meier curves, and Cox models were constructed to adjust the survival comparisons for residual case-mix differences. A total of 749 newly deteriorated patients were identified among 44,000 patients screened (1.7%). Of these, 13% were admitted to intensive care unit, 32% to special care units, and 55% to regular departments. Intensive care unit patients had better early survival (0-3 days) relative to regular departments (p=.0001) in a Cox multivariate model. Early advantage of intensive care was most pronounced among patients who acutely deteriorated while on hospital wards rather than among newly admitted patients. CONCLUSIONS:Only a small proportion of eligible patients reach the intensive care unit, and early admission is imperative for their survival advantage. As intensive care unit benefit was most pronounced among those deteriorating on hospital wards, intensive care unit triage decisions should be targeted at maximizing intensive care unit benefit by early admitting patients deteriorating on hospital wards.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Simchen E,Sprung CL,Galai N,Zitser-Gurevich Y,Bar-Lavi Y,Levi L,Zveibil F,Mandel M,Mnatzaganian G,Goldschmidt N,Ekka-Zohar A,Weiss-Salz I

doi

10.1097/01.CCM.0000253407.89594.15

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

449-57

issue

2

eissn

0090-3493

issn

1530-0293

journal_volume

35

pub_type

杂志文章
  • Helicobacter pylori infection in intensive care: increased prevalence and a new nosocomial infection.

    abstract:OBJECTIVE:The pathogenesis of acute gastric stress ulceration in the seriously ill is uncertain, and any role of Helicobacter pylori infection is unknown. We aimed to assess the relationship between H. pylori serological status and stress ulceration in seriously ill patients, as well as H. pylori serological status in ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199907000-00010

    authors: Robertson MS,Cade JF,Clancy RL

    更新日期:1999-07-01 00:00:00

  • Bulk diffusion apnea test in the diagnosis of brain death.

    abstract:OBJECTIVE:To assess the efficacy of bulk diffusion in maintaining oxygenation during apnea testing for brain death. DESIGN:Case series. SETTING:ICU in a primary care hospital. PATIENTS:Twenty-four consecutive patients with suspected brain death. Most patients suffered cerebral trauma from vehicular accidents. INTER...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199211000-00014

    authors: al Jumah M,McLean DR,al Rajeh S,Crow N

    更新日期:1992-11-01 00:00:00

  • Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.

    abstract:OBJECTIVES:The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (4...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001358

    authors: Alogna A,Manninger M,Schwarzl M,Zirngast B,Steendijk P,Verderber J,Zweiker D,Maechler H,Pieske BM,Post H

    更新日期:2016-03-01 00:00:00

  • Chloride Content of Fluids Used for Large-Volume Resuscitation Is Associated With Reduced Survival.

    abstract:OBJECTIVE:We sought to investigate if the chloride content of fluids used in resuscitation was associated with short- and long-term outcomes. DESIGN:We identified patients who received large-volume fluid resuscitation, defined as greater than 60 mL/kg over a 24-hour period. Chloride load was determined for each patien...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002063

    authors: Sen A,Keener CM,Sileanu FE,Foldes E,Clermont G,Murugan R,Kellum JA

    更新日期:2017-02-01 00:00:00

  • Epidemiology, management, and outcome of severe acute renal failure of critical illness in Australia.

    abstract:OBJECTIVE:To study the epidemiology, style of management, and outcome of intensive care patients with acute renal failure requiring replacement therapy in Australia. DESIGN:Prospective epidemiologic study. SETTING:Australian adult intensive care units providing acute renal replacement therapy. PATIENTS:Adult intensi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200110000-00010

    authors: Silvester W,Bellomo R,Cole L

    更新日期:2001-10-01 00:00:00

  • Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review.

    abstract:CONTEXT:The results of studies on noninvasive positive pressure ventilation (NPPV) for acute hypoxemic respiratory failure unrelated to cardiogenic pulmonary edema have been inconsistent. OBJECTIVE:To assess the effect of NPPV on the rate of endotracheal intubation, intensive care unit and hospital length of stay, and...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccm.0000148011.51681.e2

    authors: Keenan SP,Sinuff T,Cook DJ,Hill NS

    更新日期:2004-12-01 00:00:00

  • Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation.

    abstract:OBJECTIVE:To define changes in intramyocardial pH and PCO2 during cardiac arrest and resuscitation. DESIGN:Prospective and observational trial. SETTING:Mammalian research laboratory utilizing a porcine model of cardiac arrest. SUBJECTS:Sixteen domestic pigs. INTERVENTIONS:Ventricular fibrillation was induced by an ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199306000-00020

    authors: Kette F,Weil MH,Gazmuri RJ,Bisera J,Rackow EC

    更新日期:1993-06-01 00:00:00

  • Brain Injury Is More Common in Venoarterial Extracorporeal Membrane Oxygenation Than Venovenous Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Despite the common occurrence of brain injury in patients undergoing extracorporeal membrane oxygenation, it is unclear which cannulation method carries a higher risk of brain injury. We compared the prevalence of brain injury between patients undergoing venoarterial and venovenous extracorporeal membrane ox...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004618

    authors: Shoskes A,Migdady I,Rice C,Hassett C,Deshpande A,Price C,Hernandez AV,Cho SM

    更新日期:2020-12-01 00:00:00

  • Energy expenditure and withdrawal of sedation in severe head-injured patients.

    abstract:OBJECTIVES:To determine the outcome of oxygen consumption (VO2) and energy expenditure after cessation of sedation in severe head-injured patients and to assess its usefulness as a predictor of neurologic severity. DESIGN:Prospective, descriptive study. SETTING:Neurosurgical intensive care unit (ICU) in a university ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199407000-00011

    authors: Bruder N,Lassegue D,Pelissier D,Graziani N,François G

    更新日期:1994-07-01 00:00:00

  • Clinical correlates of successful weaning from mechanical ventilation in severe bronchopulmonary dysplasia.

    abstract::The hospital records of 7 patients with severe bronchopulmonary dysplasia (BPD) were reviewed. All patients were ventilator dependent for prolonged periods (mean duration intermittent mandatory ventilation (IMV) 14.3 +/- 3.5 months) but eventually were successfully weaned from mechanical ventilation and sent home. The...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198112000-00001

    authors: Morray JP,Fox WW,Kettrick RG,Downes JJ

    更新日期:1981-12-01 00:00:00

  • Comparative effects of early versus delayed use of norepinephrine in resuscitated endotoxic shock.

    abstract:OBJECTIVE:To assess hemodynamic, tissue oxygenation, and tissue perfusion changes by comparing traditional therapy (fluid resuscitation followed by vasopressor treatment) and alternative therapy (early vasopressor treatment) in a hyperkinetic and sedated model of endotoxic shock. DESIGN:Prospective controlled experime...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000269028.28521.08

    authors: Sennoun N,Montemont C,Gibot S,Lacolley P,Levy B

    更新日期:2007-07-01 00:00:00

  • Distribution and pathophysiology of acute lobar collapse in the pediatric intensive care unit.

    abstract:OBJECTIVE:The high incidence of lower lobe collapse in adult intensive care patients is well described. We aimed to document the incidence and distribution of acute lobar collapse in the pediatric intensive care setting. The influence of anatomical and pathophysiological differences between the adult and pediatric resp...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199908000-00035

    authors: Thomas K,Habibi P,Britto J,Owens CM

    更新日期:1999-08-01 00:00:00

  • Suspended animation for delayed resuscitation from prolonged cardiac arrest that is unresuscitable by standard cardiopulmonary-cerebral resuscitation.

    abstract::Standard cardiopulmonary-cerebral resuscitation fails to achieve restoration of spontaneous circulation in approximately 50% of normovolemic sudden cardiac arrests outside hospitals and in essentially all victims of penetrating truncal trauma who exsanguinate rapidly to cardiac arrest. Among cardiopulmonary-cerebral r...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-200011001-00012

    authors: Safar P,Tisherman SA,Behringer W,Capone A,Prueckner S,Radovsky A,Stezoski WS,Woods RJ

    更新日期:2000-11-01 00:00:00

  • Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials.

    abstract:OBJECTIVES:Randomized trials have suggested that hypertonic saline solutions may be superior to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical practice has been limited, partly by their small size. We therefore combined their findings in a meta-analysis. DATA SOURCES:We sear...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/CCM.0b013e318206b9be

    authors: Kamel H,Navi BB,Nakagawa K,Hemphill JC 3rd,Ko NU

    更新日期:2011-03-01 00:00:00

  • Esophageal and transpulmonary pressures in acute respiratory failure.

    abstract:OBJECTIVE:Pressure inflating the lung during mechanical ventilation is the difference between pressure applied at the airway opening (Pao) and pleural pressure (Ppl). Depending on the chest wall's contribution to respiratory mechanics, a given positive end-expiratory and/or end-inspiratory plateau pressure may be appro...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000215515.49001.A2

    authors: Talmor D,Sarge T,O'Donnell CR,Ritz R,Malhotra A,Lisbon A,Loring SH

    更新日期:2006-05-01 00:00:00

  • Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus.

    abstract:OBJECTIVE:Carbon monoxide (CO), an endogenous byproduct of heme metabolism, is produced at high levels in injured tissue via induction of heme-oxygenase-1 activity, where it contributes to the modulation of proinflammatory processes. Alone, CO has potent anti-inflammatory effects in models of acute and chronic inflamma...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000166349.76514.40

    authors: Moore BA,Overhaus M,Whitcomb J,Ifedigbo E,Choi AM,Otterbein LE,Bauer AJ

    更新日期:2005-06-01 00:00:00

  • Critical Care Ultrasound: A Systematic Review of International Training Competencies and Program.

    abstract:OBJECTIVES:Critical care ultrasonography has become established within ICUs as a diagnostic tool and to guide management strategies and practical procedures. Following an international consensus statement in 2011, various national professional societies and organizations have sought to develop and deliver training prog...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003626

    authors: Wong A,Galarza L,Duska F

    更新日期:2019-03-01 00:00:00

  • Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study.

    abstract:OBJECTIVES:Secretoneurin is associated with cardiomyocyte Ca handling and improves risk prediction in patients with acute myocardial dysfunction. Whether secretoneurin improves risk assessment on top of established cardiac biomarkers and European System for Cardiac Operative Risk Evaluation II in patients undergoing ca...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003670

    authors: Brynildsen J,Petäjä L,Myhre PL,Lyngbakken MN,Nygård S,Stridsberg M,Christensen G,Ottesen AH,Pettilä V,Omland T,Røsjø H

    更新日期:2019-05-01 00:00:00

  • Experiencing the pediatric intensive care unit: perspective from parents of children with severe antecedent disabilities.

    abstract:OBJECTIVE:To describe the experience of pediatric intensive care hospitalization from the perspective of a parents of children with severe, antecedent disability. DESIGN:Qualitative analysis of data obtained through semistructured interviews. SETTING:Pediatric intensive care unit (PICU) in a children's hospital. SUB...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181a00578

    authors: Graham RJ,Pemstein DM,Curley MA

    更新日期:2009-06-01 00:00:00

  • Association of pulmonary artery catheter use with in-hospital mortality.

    abstract:OBJECTIVE:To determine the association of pulmonary artery catheter (PAC) use with in-hospital mortality. DESIGN:Prospective, observational study. SETTING:The medical intensive care units (MICU) of two teaching hospitals. METHODS:The study included 751 adults who were admitted to the MICU, excluding those who stayed...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200106000-00010

    authors: Afessa B,Spencer S,Khan W,LaGatta M,Bridges L,Freire AX

    更新日期:2001-06-01 00:00:00

  • ST changes during sodium nitroprusside therapy in acute myocardial infarction.

    abstract::Nineteen patients with acute anterior myocardial infarction who were hypertensive (systolic BP greater than or equal to 170 mm Hg and/or diastolic BP greater than or equal to 100 mm Hg) at the time of admission were treated with continuous infusion of sodium nitroprusside (NP). The administration of NP resulted in a s...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198310000-00010

    authors: Rucabado L,Miñana J,Cebrián J,Monsalve F,Cuñat J,Ruano M

    更新日期:1983-10-01 00:00:00

  • High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis.

    abstract:OBJECTIVES:Despite having dysregulated iron metabolism, critically ill patients may receive exogenous iron for the treatment of anemia. Iron is associated with increased tissue apoptosis and may facilitate bacterial growth. We hypothesized that exogenous iron administration given after the onset of sepsis would lead to...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000124878.02614.4c

    authors: Javadi P,Buchman TG,Stromberg PE,Husain KD,Dunne WM,Woolsey CA,Turnbull IR,Hotchkiss RS,Karl IE,Coopersmith CM

    更新日期:2004-05-01 00:00:00

  • Endotoxin increases plasma leptin and ghrelin levels in dogs.

    abstract:OBJECTIVE:Evaluations of plasma leptin and ghrelin levels and their relations with circulating levels of proinflammatory mediators, stress hormones, and biochemical markers of hepatorenal injury during experimental endotoxemia in dogs. SETTING:Uludag University. DESIGN:Placebo-controlled animal study. ANIMALS:Adult ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0B013E3181611F5AA

    authors: Yilmaz Z,Ilcol YO,Ulus IH

    更新日期:2008-03-01 00:00:00

  • Report on the development of a procedure to prevent placement of feeding tubes into the lungs using end-tidal CO2 measurements.

    abstract:OBJECTIVE:To determine the accuracy of a technique using capnography to prevent inadvertent placement of small-bore feeding tubes and Salem sump tubes into the lungs. SETTING:Twelve-bed medical intensive care unit (MICU) in a 557-bed teaching hospital. PATIENTS:A total of 25 ventilated adult MICU patients were studie...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003246-200105000-00004

    authors: Burns SM,Carpenter R,Truwit JD

    更新日期:2001-05-01 00:00:00

  • Continuous noninvasive estimation of cardiac output by electrical bioimpedance: an experimental study in dogs.

    abstract::A new device has been developed to estimate continuously and noninvasively cardiac output from the thoracic electrical bioimpedance (CObi). CObi was compared to cardiac output by thermodilution (COtd) in five anesthetized dogs. Blood pressure, blood volume, and blood flow were manipulated by hemorrhage and infusions o...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198603000-00013

    authors: Tremper KK,Hufstedler SM,Barker SJ,Zaccari J,Harris D,Anderson S,Roohk V

    更新日期:1986-03-01 00:00:00

  • Prevention of hemolysis-induced organ damage by nutritional activation of the vagal anti-inflammatory reflex*.

    abstract:OBJECTIVES:Acute hemolysis is associated with organ damage, inflammation, and impaired vascular function. Stimulation of the cholecystokinin-1 receptor-dependent vagal anti-inflammatory reflex with lipid-rich enteral nutrition was demonstrated to prevent tissue damage and attenuate inflammation. This study investigates...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31828e9262

    authors: de Haan JJ,Windsant IV,Lubbers T,Hanssen SJ,Hadfoune M,Prinzen FW,Greve JW,Buurman WA

    更新日期:2013-11-01 00:00:00

  • Intravenous insulin nomogram improves blood glucose control in the critically ill.

    abstract:OBJECTIVE:To improve control of blood glucose concentrations in critically ill patients through use of a bedside, nurse-managed, intravenous insulin nomogram. DESIGN:Retrospective, before-after cohort study. SETTING:Fifteen-bed mixed medical/surgical intensive care unit in a tertiary, teaching hospital. PATIENTS:A t...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200109000-00010

    authors: Brown G,Dodek P

    更新日期:2001-09-01 00:00:00

  • At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers.

    abstract:OBJECTIVES:To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients. DESIGN:Prospective observational cohort study. SETTING:A 21-bed polyvalent ICU in a university hospital....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318174dd75

    authors: Gacouin A,Legay F,Camus C,Volatron AC,Barbarot N,Donnio PY,Thomas R,Le Tulzo Y

    更新日期:2008-06-01 00:00:00

  • Therapeutic hypothermia after cardiac arrest in clinical practice: review and compilation of recent experiences.

    abstract:OBJECTIVES:We sought to review findings from recent literature on the postresuscitation care of cardiac arrest patients using therapeutic hypothermia as part of nontrial treatment. DESIGN:Literature review. SETTING:Hospital-based environment. SUBJECTS:Patients initially resuscitated from cardiac arrest who underwent...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0b013e3181aa5c7c

    authors: Sagalyn E,Band RA,Gaieski DF,Abella BS

    更新日期:2009-07-01 00:00:00

  • Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department.

    abstract:OBJECTIVE:First, to determine whether procalcitonin (PCT) significantly adds diagnostic value in terms of sensitivity and specificity to a common set of markers of infection, including C-reactive protein (CRP), at the Emergency Department. Second, to create a simple scoring rule implementing PCT values. Third, to deter...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181b9ec33

    authors: de Kruif MD,Limper M,Gerritsen H,Spek CA,Brandjes DP,ten Cate H,Bossuyt PM,Reitsma PH,van Gorp EC

    更新日期:2010-02-01 00:00:00