Abstract：
AIM:The aim of the study was to identify risk factors of relapse by investigating relationships among suicidality, impulsivity, genetic markers of serotonin activity, and relapse in alcohol-dependent patients. METHODS:90 alcohol dependent patients were followed for 12 months after the baseline assessment, which entailed evaluation of suicidality and impulsivity as well as collection of DNA samples. Polymorphisms of genes involved in the synthesis and activity of the serotonin system were analyzed. After 12 months from the first visit, the patients were re-contacted and interviewed for relapse. RESULTS:Relapse rates were significantly higher among patients with the history of suicidal attempts recorded at the baseline assessment. The genetic analysis showed that patients with the G/G genotype in the 5HTR1A gene were more likely to relapse, whereas patients with the C/C genotype were more likely to abstain. Moreover, there was a strong trend for an association between the G/G genotype and a history of suicide attempts. CONCLUSIONS:High level of suicidality may predict relapse in alcoholic patients. Altered serotonergic function increases the risk of a suicide attempt and may contribute to higher risk of relapse in alcohol dependent patients.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Wojnar M,Brower KJ,Jakubczyk A,Zmigrodzka I,Burmeister M,Matsumoto H,Woźny E,Sliwerska E,Hegedus AM,Husar A,Slufarska A,Lipiński M,Zucker RAsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
985-94issue
5eissn
0033-2674issn
2391-5854journal_volume
40pub_type
杂志文章abstract：:The aim of the literature review was the problem of psychiatric complications of intensive chemo- and radiotherapy, which were used in childhood. These days most children who suffer from acute leukaemia are successfully treated. Most studies indicate cognitive dysfunctions, anxiety and mood disorders. These days a new...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:The aim of the study was to investigate the relationship between insight and cognitive function in patients diagnosed with schizophrenia. Insight into illness is a clinically important feature influencing clinical outcome and prognosis in schizophrenia. One ofthe most important and widely discussed in recent litera...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：:The author discusses the metabolism of disulfiram and the enzymes which metabolize ethanol. The restraining of the activity of ALDH in the liver by disulfiram causes an accumulation of acetaldehyde which in their turn cause a series of psychophysical symptoms which are unpleasant and in some instances dangerous for th...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：1992-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
abstract：:Self-report methods are commonly applied in medicine and psychology. However, their diagnostic value in assessment of patients with acquired brain damage can be limited due to a number of various difficulties encountered by these patients, including cognitive disorders, fatigue, similarity of psychopathological and so...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-05-01 00:00:00
abstract：AIM:Currently, the use of first generation antipsychotics (FGA) is strongly limited. On the other hand, treatment with second generation antipsychotics (SGA) can not be applied in every patient. Therefore, there is an urgent necessity to obtain information about the knowledge and experience of clinicians with regard to...
journal_title：Psychiatria polska
pub_type： 共识发展会议,杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:The paper presents a review of recent data on research and clinical significance of gating of the P50 component of the auditory evoked potentials (AEP). Information filters are a necessary element for the proper functioning of the brain. It appears as though they have an important role in the information-transfer mech...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/96286
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 信件
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更新日期：2015-05-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/32566
更新日期：2015-01-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/109157
更新日期：2020-06-30 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Anxiety and anxiety disorders among people with visual impairment are more frequent than in the general population. It is estimated that . of people with visual impairment face depression and/or anxiety, whereas 4-6% of people are diagnosed with anxiety disorders. The purpose of this paper is analyzing the occurrence ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/OnlineFirst/85408
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：1992-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Psychiatria polska
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doi：10.12740/PP/OnlineFirst/75666
更新日期：2018-10-27 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/31748
更新日期：2015-01-01 00:00:00
abstract：:A polish translation and the description of the clinical use of the novel screening tool in Alzheimer's disease, a "7 Minute Screen", is presented. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
