Cytogenetics and cancer.

Abstract:

:When present, chromosome abnormalities can contribute useful information for tumor diagnosis and prognosis. However, the existence of diploid tumor cells indicates that such abnormalities are not necessary in tumors. Their time of appearance, sometimes preceding or predisposing to tumor and sometimes occurring late in disease, also suggests that chromosomal events are not critical. Rather, they should be considered as markers of the underlying and essential gene changes. The great frequency of chromosome aberrations in human tumors probably reflects two roles: (1) they provide an efficient means to effect a multiplicity of gene changes, and (2) they permit rapid cellular evolution.

journal_name

Arch Pathol Lab Med

authors

Wolman SR

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

15-9

issue

1

eissn

0003-9985

issn

1543-2165

journal_volume

108

pub_type

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