Gastric myeloid metaplasia: a case report and review of the literature.

Abstract:

:We report a case of gastric myeloid metaplasia in an 89- year-old woman with agnogenic myeloid metaplasia. The lesions were fortuitously discovered on upper endoscopy. The antral mucosa was thickened and polypoid, and on histologic examination contained immature granulocytes, megakaryocytes, and a few erythroblasts without desmoplastic stromal reaction. The granulocytes were positive for CD15, CD68, and myeloperoxidase on immunohistochemistry, and the megakaryocytes showed positive reactivity for factor VIII. Gastric myeloid metaplasia is a very rare event, and to our knowledge only 6 cases have been reported in the literature to date. It usually occurs in patients with advanced myeloproliferative syndrome. Gastric myeloid metaplasia often has a pseudotumoral appearance, leading to digestive symptoms. Histologic diagnosis is straightforward when trilinear hematopoietic elements are identified in gastric biopsies. Immunohistochemistry with anti-factor VIII antibody can be useful to confirm the presence of megakaryocytes.

journal_name

Arch Pathol Lab Med

authors

Chatelain D,Devendeville A,Rudelli A,Bruniau A,Geslin G,Sevestre H

doi

10.1043/1543-2165(2004)128<568:GMMACR>2.0.CO;2

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

568-70

issue

5

eissn

0003-9985

issn

1543-2165

pii

CR3116

journal_volume

128

pub_type

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