Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features.

Abstract:

CONTEXT:Basal-like breast carcinoma (BLBC) is a distinct molecular subtype of breast carcinoma identified through gene expression profiling studies. OBJECTIVE:To provide the clinical background, the histologic profile, and the immunohistochemical profile of these tumors and discuss the current knowledge of their molecular signature and their implications on targeted molecular therapy. DATA SOURCES:Data were obtained from review of the pertinent peer-reviewed literature. CONCLUSIONS:Basal-like breast carcinomas are aggressive tumors with poor prognosis. Lack of targeted therapy makes their treatment a challenging task. Traditional chemotherapy is still associated with a high risk of relapse and death in a high percentage of patients. Platinum-based chemotherapy has been considered as a candidate for the treatment of BLBCs owing to their BRCA1 phenotype. Approximately 22% of patients treated with single-agent cisplatin show pathologic complete response, which is a comparable rate to that seen with nonplatinum agents. Antiangiogenic agents have been promising, but their currently demonstrated limited response is considered disappointing. Additionally, epidermal growth factor receptor was not shown to be a helpful target for BLBC. A recent study has shown that BLBC appears to be especially sensitive to MEK inhibitors, making it a promising therapeutic possibility. The list of new targets is still evolving and the "magic" therapeutic target is yet to be discovered.

journal_name

Arch Pathol Lab Med

authors

Leidy J,Khan A,Kandil D

doi

10.5858/arpa.2012-0439-RA

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

37-43

issue

1

eissn

0003-9985

issn

1543-2165

journal_volume

138

pub_type

杂志文章,评审
  • Evolution of liver disease in morbid obesity after small-intestinal bypass and its restoration. A case report.

    abstract::We studied a woman who underwent a jejunoileal bypass for the treatment of morbid obesity and in whom severe jaundice and hepatic failure developed six months later; these developments prompted restoration of the normal continuity of the small bowel. Four serial wedge biopsy specimens of the liver were taken during a ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Allam C,Bala'a M,Shamma'a M

    更新日期:1983-04-01 00:00:00

  • Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis.

    abstract:CONTEXT:Lesions associated with monoclonal light and heavy chains display a variety of glomerular, tubular interstitial, and vascular manifestations. While some of the entities are well recognized, including light and heavy chain deposition diseases, AL (light chain) and AH (heavy chain) amyloidosis, and light chain ("...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,多中心研究

    doi:10.5858/arpa.2013-0493-OA

    authors: Herrera GA

    更新日期:2014-10-01 00:00:00

  • Surgical pathology accessioning and management on a multiuser hard disk microcomputer system.

    abstract::We have developed an inexpensive, microcomputer-based, multiuser hard disk system for surgical pathology that uses a commercially available word processor and data base manager, linked together by several BASIC programs written by us. System functions include keyboard input of patient demographic data and specimen inf...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Talamo TS,Losos FJ 3rd

    更新日期:1985-01-01 00:00:00

  • The Medicare and Clinical Laboratories Improvement Act of 1967 proficiency testing requirements and its relationship to the private sector.

    abstract::The Health Care Financing Administration of the US Department of Health and Human Services is the federal agency that has the responsibility for the administration of the Medicare and Clinical Laboratories Improvement Act of 1967 programs, including the promulgation of standards for clinical laboratories. The Health C...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Edinger SE

    更新日期:1988-04-01 00:00:00

  • Metastatic angiosarcoma masquerading as diffuse pulmonary hemorrhage: clinicopathologic analysis of 7 new patients.

    abstract:CONTEXT:Diffuse pulmonary hemorrhage is an uncommon presenting manifestation of angiosarcoma. OBJECTIVE:To review the clinical, radiologic, and pathologic findings of patients with metastatic angiosarcoma who presented with diffuse pulmonary hemorrhage. DESIGN:Patients fulfilling inclusion criteria were identified fr...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<1562:MAMADP>2.0.CO;2

    authors: Adem C,Aubry MC,Tazelaar HD,Myers JL

    更新日期:2001-12-01 00:00:00

  • Paraproteins are a common cause of interferences with automated chemistry methods.

    abstract:CONTEXT:Previous studies have shown that paraproteins caused spurious results on individual analytes including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C). Studies demonstrating paraprotein interferences with multiple analytes measured by different analyzers have not been reported. OBJE...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2008)132[217:PAACCO]2.0.CO;2

    authors: Yang Y,Howanitz PJ,Howanitz JH,Gorfajn H,Wong K

    更新日期:2008-02-01 00:00:00

  • Demonstration of iron and thorium in autopsy tissues by X-ray microanalysis.

    abstract::We performed x-ray microanalysis of autopsy specimens using a scanning-transmission electron microscopy mode. Tissues were obtained at necropsy from a patient with history of angiography using thorium dioxide and from a patient with hemochromatosis. X-ray microanalysis confirmed the presence of thorium and iron in the...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Landas S,Turner JW,Moore KC,Mitros FA

    更新日期:1984-03-01 00:00:00

  • Mixed epithelial and stromal tumors of the kidney: an overview.

    abstract::Mixed epithelial and stromal tumor of the kidney is a recently recognized distinct neoplasm that should be distinguished from other renal neoplasms. These tumors are relatively rare with a female preponderance. Imaging studies are not diagnostic but reveal a solid or solid and cystic mass in most cases. Histopathologi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165-133.9.1483

    authors: Mohanty SK,Parwani AV

    更新日期:2009-09-01 00:00:00

  • Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance--it is time to appreciate the Azzopardi concept!

    abstract:CONTEXT:More than 25 years ago, John G. Azzopardi described a distinctive intraepithelial neoplastic breast lesion, which he designated "clinging carcinoma in situ"; he considered it as another variant of ductal carcinoma in situ, an early lesion that can easily be missed because the changes are mainly cytologic rather...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165-133.6.879

    authors: Moinfar F

    更新日期:2009-06-01 00:00:00

  • Independent learning in pathology. Does it work?

    abstract::The sophomore pathology course at the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, was substantially modified with the intention of promoting guided, independent learning. The emphasis has been shifted from lectures to other modalities of instruction. This article...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Raskova J,Martin EG,Trelstad RL,Shea SM

    更新日期:1989-02-01 00:00:00

  • Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.

    abstract::Calbindin-D28k is a highly conserved 28,000 (dalton) molecular-weight (Mr) calcium binding protein with broad tissue distribution, yet cell-type-specific expression predominantly in subpopulations of central and peripheral nervous system neurons, distal tubular cells of the kidney, and enteric neuroendocrine cells. A ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Katsetos CD,Jami MM,Krishna L,Jackson R,Patchefsky AS,Cooper HS

    更新日期:1994-06-01 00:00:00

  • Lung cancer genotype-based therapy and predictive biomarkers: present and future.

    abstract:CONTEXT:The advent of genotype-based therapy and predictive biomarkers for lung cancer has thrust the pathologist into the front lines of precision medicine for this deadly disease. OBJECTIVE:To provide the clinical background, current status, and future perspectives of molecular targeted therapy for lung cancer patie...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2012-0508-RA

    authors: Cagle PT,Allen TC

    更新日期:2012-12-01 00:00:00

  • Immunofluorescence for serodiagnosis of retrovirus infection.

    abstract::Indirect immunofluorescence antibody testing is a mainstay of retrovirus serodiagnosis in the public health community, affording quick, inexpensive, and clear results with significant advantages over Western blot testing. Limitations regarding training of personnel and availability of reagents will probably continue a...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Ascher MS,Wilber JC

    更新日期:1990-03-01 00:00:00

  • Frozen section and the surgical pathologist: a point of view.

    abstract::Frozen section is a prominent point of intersection between surgeons and pathologists. It is regarded as the most definitive--but not the sole--form of intraoperative consultation. Its role in tissue triage, diagnosis, and intraoperative management should not be misconstrued as a shortcut to a definitive diagnosis. Al...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165-133.7.1135

    authors: Taxy JB

    更新日期:2009-07-01 00:00:00

  • Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.

    abstract:CONTEXT.—:Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management dif...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2018-0226-RA

    authors: Ronnett BM

    更新日期:2018-12-01 00:00:00

  • Metastatic foci of signet ring cell carcinoma in a tubular adenoma of the colon.

    abstract::We describe a case of adenomatous polyp of the colon that harbored small foci of signet ring cell carcinoma. The patient was a 64-year-old woman with end-stage renal disease and sepsis who underwent colonoscopy to evaluate the possibility of pseudomembranous colitis. A polyp was found incidentally in the right colon a...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2003)127<1509:MFOSRC>2.0.CO;2

    authors: Bismar TA,Maluf H,Wang HL

    更新日期:2003-11-01 00:00:00

  • Complete blood count indices in colorectal carcinoma.

    abstract::Since carcinomas of the colon or rectum are associated with blood loss, we wondered if complete blood count data were suggestive of iron deficiency in cases of colorectal carcinoma. The mean corpuscular volume and especially the red blood cell distribution width are thought to be more sensitive to early iron deficienc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Speights VO,Johnson MW,Stoltenberg PH,Rappaport ES,Helbert B,Riggs MW

    更新日期:1992-03-01 00:00:00

  • Pseudoneoplastic mimics of prostate and bladder carcinomas.

    abstract:CONTEXT:The differential diagnoses of prostatic carcinoma and bladder epithelial neoplasms include several histologic mimics that should be known to avoid misdiagnosis. OBJECTIVE:To discuss pseudoneoplastic lesions of the prostate and bladder that could potentially be confused with prostatic carcinoma and bladder epit...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165-134.3.427

    authors: Hameed O,Humphrey PA

    更新日期:2010-03-01 00:00:00

  • Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma.

    abstract::A 48-year-old Japanese woman died of multiple myeloma (lambda light-chain type) with chronic renal failure. Histological examination revealed deposition of a homogeneous substance and crystals in the kidneys and thyroid gland. The homogeneous substance was stained with Congo red after permanganate treatment but did no...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hirota S,Miyamoto M,Kasugai T,Kitamura Y,Morimura Y

    更新日期:1990-04-01 00:00:00

  • Abstract/Case Study Review Committee for the College of American Pathologists 2016 Annual Meeting (CAP16).

    abstract::The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP16 meeting. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2016-0240-AB

    authors:

    更新日期:2016-09-01 00:00:00

  • The role of the immunogenetics laboratory in marrow transplantation.

    abstract::Allogeneic marrow transplants from genotypically HLA-identical siblings have become lifesaving therapy for patients with various congenital and acquired diseases of the immune and hematopoietic systems. Unfortunately, less than 30% of patients in the United States have an HLA-identical sibling; therefore, many are den...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Anasetti C

    更新日期:1991-03-01 00:00:00

  • A simple and reliable rapid methenamine silver stain for Pneumocystis carinii and fungi.

    abstract::A modification to a rapid hot methenamine silver stain is described that shortens the silver staining step of the procedure to one to five minutes. It also eliminates the requirement to manipulate hot solutions. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Shimono LH,Hartman B

    更新日期:1986-09-01 00:00:00

  • Malignant lymphoma with primary presentation in the spleen. A study of 20 patients.

    abstract::We describe 20 adult patients with malignant lymphoma with primary presentation in the spleen. The most common presenting symptoms were fever, malaise, and weight loss. Physical examination revealed prominent splenomegaly without palpable lymphadenopathy. Small lymphocytic lymphoma was the most frequent histologic typ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Spier CM,Kjeldsberg CR,Eyre HJ,Behm FG

    更新日期:1985-12-01 00:00:00

  • An unusual case of peripheral T-cell lymphoma with CD56 positivity and angiocentric, angiodestructive morphology arising in the ileum.

    abstract::Natural killer cell and cytotoxic T-cell lymphomas are frequently difficult to distinguish because they share many common features, and yet it is important to make an accurate diagnosis because their prognoses differ. We report an unusual case of a white man with a CD56-positive T-cell lymphoma in the ileum. The histo...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2005)129<527:AUCOPT>2.0.CO;2

    authors: Frank MC,Bono E,Sun T

    更新日期:2005-04-01 00:00:00

  • Recommended policies for uses of human tissue in research, education, and quality control. Ad Hoc Committee on Stored Tissue, College of American Pathologists.

    abstract::As recipients of tissue and medical specimens, pathologists and other medical specialists regard themselves as stewards of patient tissues and consider it their duty to protect the best interests of both the individual patient and the public. The stewardship of slides, blocks, and other materials includes providing, u...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(1999)123<0296:RPFUOH>2.0.CO;2

    authors: Grizzle W,Grody WW,Noll WW,Sobel ME,Stass SA,Trainer T,Travers H,Weedn V,Woodruff K

    更新日期:1999-04-01 00:00:00

  • Clinical and laboratory considerations of culture vs antigen assays for detection of Chlamydia trachomatis from genital specimens.

    abstract::Assays for Chlamydia trachomatis antigen are being increasingly used in lieu of traditional cell culture methods for detection of the organism in patient specimens. While results from these assays are available considerably earlier than are those from culture, the assays have been less sensitive and specific than cult...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Kellogg JA

    更新日期:1989-05-01 00:00:00

  • Defining Normal Healthy Term Newborn Automated Hematologic Reference Intervals at 24 Hours of Life.

    abstract:CONTEXT.—:Automated analyzers have advanced the field of clinical hematology, mandating updated complete blood count (CBC) reference intervals (RIs) to be clinically useful. Contemporary newborn CBC RI publications are mostly retrospective, which some authors have cited as one of their cardinal limitations and recommen...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2019-0444-OA

    authors: Ianni B,McDaniel H,Savilo E,Wade C,Micetic B,Johnson S,Gerkin R

    更新日期:2020-04-16 00:00:00

  • Interpretive criteria of the Western blot assay for serodiagnosis of human immunodeficiency virus type 1 infection.

    abstract::This project was designed to evaluate different criteria used in the interpretation of the human immunodeficiency virus type 1 (HIV-1) Western blot assay on a group of serum samples blinded to the examiner that were collected from individuals attending three different public health departments in central North Carolin...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: O'Gorman MR,Weber D,Landis SE,Schoenbach VJ,Mittal M,Folds JD

    更新日期:1991-01-01 00:00:00

  • Atypical Ductal Lesions of the Breast: Criteria, Significance, and Laboratory Updates.

    abstract:CONTEXT.—:Atypical ductal hyperplasia (ADH) is a challenging diagnosis defined by cytologic and architectural features that carries an increased risk of subsequent carcinoma when diagnosed in isolation. In addition, ADH may secondarily involve benign breast lesions, wherein it carries variable clinical significance. O...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2018-0221-RA

    authors: East EG,Carter CS,Kleer CG

    更新日期:2018-10-01 00:00:00

  • Teratoid hepatoblastoma with abundant neuroendocrine and squamous differentiation with extensive parenchymal metastasis.

    abstract::Teratoid hepatoblastoma is a rare histologic subtype accounting for 4% to 10% of all hepatoblastomas and is characterized by the presence of divergent differentiation, including squamous, mucinous, melanocytic, cartilaginous, osseous, skeletal muscle, and neural elements. It is postulated that the teratoid elements mi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0212-CR

    authors: Rabah R

    更新日期:2012-08-01 00:00:00