Abstract:
BACKGROUND:Desmin plays one of the key roles in cardiomyocytes. The protein protects the integration of the cell and has the following actions: mechanical, structural and regulatory. Observed abnormalities of its activity have been associated with worsening of heart failure (HF). AIM:Evaluation of desmin activity detected with immunohistochemical (IHC) and immunofluorescent (IF) staining in cardiomyocytes in patients with chronic HF. METHODS:The study population comprised 37 patients (mean age 46.5+/-15.28 years, 83.8% males) with diagnosed HF of unknown aetiology, who underwent myocardial biopsy. Coronary angiography was performed to exclude presence of significant coronary artery disease. Heart failure was diagnosed based on clinical assessment and echocardiography showing left ventricular ejection fraction below 45%. RESULTS:The IHC and IF evaluation of cardiomyocyte desmin showed that these methods were consistent with respect to classification of 31 specimens (83.8%), while being discrepant in 6 (16.2%) cases. Desmin detection in myocardial biopsy specimens with IHC staining showed normal amounts of this protein in 11 (29.8%) cases, excess in 18 (48.6%) patients and deficiency in 8 (21.6%) cases, whereas in IF stained specimens respective values were 12 (32.4%), 15 (40.6%) and 10 (27%). No significant differences were found between all desmin groups (i.e. normal level, excessive and deficiency) evaluated with IHC and IF staining (p=0.39; p=0.25; p=0.31, respectively). CONCLUSIONS:The IHC and IF methods allow evaluation of desmin activity in cardiomyocytes and division into three types of expression. Both methods have high consistency. The IHC, which is the more available method, seems to be a sufficient assay.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Pawlak A,Gil RJ,Walczak E,Fidziańska Asubject
Has Abstractpub_date
2007-03-01 00:00:00pages
229-35; discussion 236issue
3eissn
0022-9032issn
1897-4279pii
7845journal_volume
65pub_type
杂志文章abstract:BACKGROUND:Although increased left atrial size (LA) has been long regarded as one of the factors negatively influencing the long-term maintenance of sinus rhythm (SR) following cardioversion (CV) of atrial fibrillation (AF), some reports suggested that CV might be effective also in patients with large LA.Aim. We sought...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response. AIM:To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the prote...
journal_title:Kardiologia polska
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Severe cardiovascular complications are among the most important causes of mortality in systemic lupus erythematosus (SLE) patients. AIM:To assess the usefulness of echocardiography, ECG, and coronary artery calcium scoring (CACS) in the detection of myocardial ischaemia in SLE patients compared to single p...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. AIM:We aimed to evaluate the relationship between nesfatin-1 levels and slow coronary flow (SCF). METHODS:A total of 60 consecutive patients with SCF and 60 consecutive patients with normal coronary flow (NCF) were enrol...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2017.0210
更新日期:2018-01-01 00:00:00
abstract::Of adult patients of the Cardiac Defects Clinic, National Institute of Cardiology (in Warsaw) we can distinguish several groups of patients with congenital heart defects among which those who were diagnosed after the age of 18 or those who despite of early and correct diagnosis, not underwent surgery on the childhood ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND AND AIM:In patients with mitral stenosis (MS) percutaneous mitral balloon valvuloplasty (PMBV) is used to im-prove symptoms and prognosis. Although there is some evidence for potential long-term benefits from PMBV in asymptomatic patients with mitral valve area (MVA) between 1.0 and 1.5 cm2, there are no fol...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2018.0036
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:This report comprises an analysis of results of examinations performed as a part of a cardiovascular disease prevention programme funded by the National Health Fund. AIM:To determine the relationship between body mass index (BMI) and blood pressure, blood glucose and lipid metabolism abnormalities in an eth...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The survival of out-of-hospital sudden cardiac arrest (OHSCA) in Europe still remains low. The State Medical Rescue System is composed of several elements. The efficacy of each of these elements may have an influence on the victim's survival. Until now, the incidence of return of spontaneous circulation (ROS...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2016.0181
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The relationship between menopause and hypertension has been a topic of investigation for several years. In the pathogenesis of hypertension after menopause, metabolic disturbances play an important role. AIM:To assess the relationship between adipocytokines and blood pressure, lipid and glucose metabolism ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Dual antiplatelet therapy reduces the risk of thrombotic complications after primary percutaneous coronary intervention (PCI). AIM:To assess whether inhibition of platelet function attenuates microvascular damage in patients with ST-segment elevation myocardial infarction (STEMI). METHODS:We studied 83 STE...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::A case of a 29-year-old woman 18 days after delivery with catastrophic antiphospholipid syndrome secondary (CAPS) due to undiagnosed systemic lupus erythematosus, leading to cardiogenic shock is reported. Laboratory evaluation revealed increased anticardiolipin antibodies, lupus anticoagulant, antinuclear antibody and...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Genetic C3435T polymorphism of the multidrug resistance gene-1 (MDR-1) limits oral bioavailability of clopidogrel and influences prognosis in patients with myocardial infarction. AIM:To assess the effects of C3435T polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes t...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
abstract:INTRODUCTION:Recurrent atrial fibrillation (AF) in the setting of haemodynamic disturbances requires frequently repeated cardioversions, which is associated with the risk of myocardial damage. It is thus necessary to identify methods which can minimise the cardioverter impulse energy. AIM:To define the defibrillation ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Although considerable data exist regarding the function of prosthetic heart valves (PHV) at rest, few data exist regarding the response to exercise. Thus, we studied by Doppler echocardiography 81 asymptomatic patients with PHV (46 mitral, 45 aortic) of varying type and 20 normal persons before and after symptom limit...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::A case of a 56-year-old man with constrictive pericarditis which was diagnosed and operated for the first time in 1996, is described. After that, the patient has been hospitalised for several times because of heart failure. On admission to the hospital, he complained of dyspnea on exertion and peripheral edema. Comput...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:In patients treated with permanent pacing, the electrode is typically placed in the right ventricular apex (RVA). Published data indicate that such electrode placement leads to an unfavourable ventricular depolarization pattern, while right ventricular outflow tract (RVOT) pacing seems to be more physiolog...
journal_title:Kardiologia polska
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Differences between men and women in the prevalence and clinical course of coronary artery disease (CAD) have been well documented. There are no data in literature on the differences between males and females in the incidence of post-infarction left ventricular (LV) wall motion abnormalities of akinesia/dysk...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Endothelial dysfunction (ED) may indirectly influence the outcome of patients with coronary artery disease. AIM:To assess the influence of cardiac rehabilitation (CR) on endothelial function in patients after ST-segment elevation myocardial infarction (STEMI). METHODS:Twenty-nine patients scheduled for CR ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2015.0177
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Recent data from "real world" registries and some randomised trials concerning the safety and efficacy of drug-eluting stents (DES) in patients with acute ST-elevation myocardial infarction (STEMI) are equivocal. AIM:We sought to compare DES with bare-metal stents (BMS) in STEMI patients treated with primar...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Progress in non-invasive diagnostic techniques such as ultrasonography, computerised tomography or magnetic resonance caused a significant decrease in the use of diagnostic myocardial biopsy (DMB). However, recent advances in molecular biology and widening knowledge about the role of new biochemical markers ...
journal_title:Kardiologia polska
pub_type: 历史文章,杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Low-density lipoprotein cholesterol (LDL-C) is the independent risk factor for coronary artery disease. Diabetes mellitus (DM) is associated with poor outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary interventions (PCI). The relationship between L...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Patent foramen ovale (PFO) is a potential risk factor for ischaemic stroke in young individuals. An interventional method of secondary stroke prevention in PFO patients is its percutaneous closure. AIM:To assess safety and effectiveness (i.e. lack of residual shunt) of percutaneous PFO closure in patients w...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in developed countries. Despite the progress in diagnostics and treatment, it is expected that CVD will still be the main cause of death worldwide until at least 2030. From 1991 CVD mortality in Poland systematically decreased, but ...
journal_title:Kardiologia polska
pub_type: 杂志文章,多中心研究
doi:10.5603/KP.a2015.0235
更新日期:2016-01-01 00:00:00
abstract::Two extremely rare cases of adults with univentricular hearts of right ventricular morphology are presented. Pathogenesis and pathophysiology of univentricular circulation as well as anatomic variants, short information on prognosis and management are briefly discussed. Echocardiographic diagnosis of univentricular he...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Data on the results of ablation for atrial fibrillation (AF) in Poland are scarce. AIMS:The aim of the study was to compare the efficacy of ablation index (AI)-guided pulmonary vein isolation (PVI) with that of conventional contact force-based PVI. METHODS:Consecutive patients undergoing PVI for the first ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.33963/KP.15523
更新日期:2020-10-23 00:00:00
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journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::We present a case of a 70 year-old male with B-cell lymphoma of which the first clinical presentation was cardiac infiltration. The patient underwent full chemotherapy with complete tumour regression. Kardiol Pol 2011; 69, 10: 1063-1065. ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The evaluation of the left ventricular (LV) function is one of the most important elements of diagnosis in patients with cardiovascular (CV) diseases. A low LV ejection fraction (LVEF) is a strong and independent predictor of CV events. Traditionally, echocardiography characterises the LV systolic function b...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Lipid lowering therapy with statins is beneficial because of improvement in lipoprotein concentrations and additional pleiotropic effects. However, less is known about the pleotropic effect of fibrates. AIM:To investigate the effects of fenofibrate therapy on inflammatory markers and serum paraoxonase activ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00