Influence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes.

Abstract:

BACKGROUND:Genetic C3435T polymorphism of the multidrug resistance gene-1 (MDR-1) limits oral bioavailability of clopidogrel and influences prognosis in patients with myocardial infarction. AIM:To assess the effects of C3435T polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes treated with percutaneous coronary intervention with stenting. METHODS:Ninety-eight patients were divided into subgroups according to closure time (CT) measured with the Platelet Function Analyzer-100 by means of collagen/adenosine diphosphate (CADP) and collagen/epinephrine (CEPI) cartridges. Patients with CADP-CT<130 s and patients with CEPI-CT

journal_name

Kardiol Pol

journal_title

Kardiologia polska

authors

Spiewak M,Małek ŁA,Kostrzewa G,Kisiel B,Serafin A,Filipiak KJ,Płoski R,Opolski G

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

827-34

issue

8

eissn

0022-9032

issn

1897-4279

pii

13112

journal_volume

67

pub_type

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