Abstract：
BACKGROUND:Sotalol is a class III antiarrhythmic drug commonly used in various arrhythmia treatments. However, due to its potent potassium channel inhibition, it can prolong the QT interval and lead to malignant arrhythmias. Empagliflozin is an inhibitor of sodium‑glucose cotransporter 2 (SGLT2) and has a positive effect on cardiovascular outcomes. Since the effect of empagliflozin on the activation of potassium channels is unknown, there is no recommendation regarding the coadministration of these drugs. AIMS:The study aimed to evaluate the possible protective effects of empagliflozin on sotalol‑induced QT prolongation. METHODS:We randomized 24 rats into 4 groups. The control group received only physiological saline, the EMPA group, empagliflozin; the SOT group, sotalol; and the EMPA+SOT group, empagliflozin and sotalol. PR and QT intervals and heart rates were measured under anesthesia at baseline and at 1, 2, and 3 hours in lead II. RESULTS:In the SOT group, the QT and QTc intervals as well as T‑wave duration were statistically longer, whereas heart rates were lower than in the control group (P <0.001 for all parameters). Empagliflozin ameliorated sotalol‑induced QT and QTc prolongation in the EMPA+SOT group. The QT interval, T‑wave duration, and QTc interval were shorter, and the heart rate was greater than in the SOT group (P <0.001, P = 0.002, P <0.001, and P <0.001, respectively). CONCLUSION:Empagliflozin significantly ameliorates sotalol‑induced QT prolongation and could be used safely with sotalol in clinical practice. Future clinical trials might recommend the routine use of empagliflozin to prevent QTc prolongation in diabetic patients receiving sotalol.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Özgür Barış V,Dinçsoy B,Gedikli E,Erdemb Adoi
10.33963/KP.15666subject
Has Abstractpub_date
2021-01-25 00:00:00pages
53-57issue
1eissn
0022-9032issn
1897-4279journal_volume
79pub_type
杂志文章abstract：:We describe a case of an 85-year-old woman admitted to hospital because of syncope with palpitations. The patient had mistakenly taken sotalol 120 mg/d together with carvedilol 6.25 mg/d. On hospital admission, ECG showed sinus bradycardia 52 bpm with marked QT prolongation: QTc presented variability from beat to beat...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0330
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Data on the results of ablation for atrial fibrillation (AF) in Poland are scarce. AIMS:The aim of the study was to compare the efficacy of ablation index (AI)-guided pulmonary vein isolation (PVI) with that of conventional contact force-based PVI. METHODS:Consecutive patients undergoing PVI for the first ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15523
更新日期：2020-10-23 00:00:00
abstract：BACKGROUND:Out‑of‑hospital cardiac arrest (OHCA) is a severe medical condition. Prehospital care plays an essential role in patient survival. AIMS:First, the study aimed to evaluate cases of OHCA managed by cardiopulmonary resuscitation (CPR) attempts in Poland in 2018, including their frequency and patient outcomes i...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15241
更新日期：2020-05-25 00:00:00
abstract：:In patients with mitral valve prolapse syndrome (MVP) various electrophysiological abnormalities occur. There are convergent opinions concerning QT distance variability and the influence of autonomic nervous system on ventricular repolarization in this syndrome. In 38 MVP patients (group I) and 24 subjects without thi...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:In 75 patients 24-hour ecg monitoring value was compared with exercise test in diagnostics of postinfarction silent ischemia. Results compatibility of both comparing examinations was 79% with regard to only painless ischemia (p less than 0.001) and 91% to both estimated painless or painful episodes (p less than 0.001)...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) pandemic affects anticoagulation not only in those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but also in most patients who require daily anticoagulant therapy and are facing substantial limitations in medical care these days. Concomitant venous t...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15425
更新日期：2020-06-25 00:00:00
abstract：BACKGROUND:Anthracycline affects various cell lines, which may contribute to left ventricular (LV) dysfunction and vascular remodelling. AIM:To assess the complex influence of anthracycline chemotherapy on the echocardiographic parameters of LV systolic and diastolic function and indices of vascular function and struc...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0154
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Dual antiplatelet therapy reduces the risk of thrombotic complications after primary percutaneous coronary intervention (PCI). AIM:To assess whether inhibition of platelet function attenuates microvascular damage in patients with ST-segment elevation myocardial infarction (STEMI). METHODS:We studied 83 STE...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:In 17 patients aged 21-61 (mean 32) with WPW syndrome the transoseophageal stimulation was performed before and after intravenous administration of propranolol (0.1 mg/kg b.w.) and atropine (0.02 mg/kg b.w.). Pharmacological blockade of the autonomic nervous system resulted in statistically significant increase of hea...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:In patients with chronic stable coronary artery disease (CAD), well‑developed coronary collateral circulation (CCC) is known to reduce long‑term mortality. AIMS:The objective of this study was to determine the relationship of serum calprotectin (S100A8 / S100A9), angiopoietin‑1 (Ang‑1) and angiopoietin‑2 (A...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15023
更新日期：2019-12-19 00:00:00
abstract：:From the physiological point of view, carotid bodies are mainly responsible for the ventilatory response to hypoxia; however, they also take part in the regulation of sympathetic tone. According to preclinical data, these structures likely contribute to the development and progression of sympathetically mediated disea...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：10.5603/KP.a2018.0178
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Recanalisation of chronic total occlusion (CTO) of a coronary artery can be reflected by improvements in various clinical parameters. Revealing increased parasympathetic activity would constitute an additional argument for performing this procedure. AIM:To assess the effect of CTO recanalisation on barorefl...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2013.0356
更新日期：2014-01-01 00:00:00
abstract：:Precordial maps of R, S and Q waves were performed in 43 children with congenital and acquired cardiac defects, with cardiomyopathies and also in 55 healthy children. Two subgroups with the left and right ventricular hypertrophies were separated basing on a standard electrocardiogram. Multilead electrocardiogram (M60-...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Congenital abnormalities of the coronary arteries are found in 0.6-1.5% of patients in coronary angiographies and most of them are benign. Their presence may prolong the time of the examination which is important especially in patients with acute coronary syndromes (ACS). The incidence of coronary artery anomaly with ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0106
更新日期：2013-01-01 00:00:00
abstract：:Churg-Strauss syndrome is a rare systemic disease characterized by necrotising vasculitis and peripheral eosinophilia. Cardiac involvement is found in up to 64% of patients and is given a high rank among the causes of morbidity and mortality. We presented a case of 26 year-old male with Churg-Strauss syndrome and left...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:An individual assessment of global risk of death from cardiovascular diseases (CVD) should guide management, both life style changes and medical therapy, in order to decrease risk factors and improve prognosis. AIM:We assessed global risk in the Polish population and its relation to medical care, including ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:A case of a 49-year-old female with a history of two myocardial infarctions (MI) and ischaemic stroke is presented. The patient was admitted to the hospital due to a third acute MI. Laboratory investigations revealed resistance to activated protein C due to factor V Leiden mutation. Diagnosis and treatment of patients...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：:Percutaneous coronary intervention of chronic total occlusion (CTO) is one of the greatest challenges in coronary interventions. Retrograde wiring is suggested as a solution to improve the success rate of intervention for CTO. We experienced the coronary perforation during antegrade wiring at the CTO lesion and sealed...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:Normally the N-terminal domain of the LDL receptor (LDLR) binds to low-density lipoprotein through apolipoprotein B100. Mutations within the LDL receptor and/or apolipoprotein B-100 genes compromising this process may lead to congenital monogenic hypercholesterolaemias known as familial hypercholesterolaem...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:transient left ventricular ballooning syndrome (TLVBS) has been recently recognised as an acute disease mimicking myocardial infarction. AIM:we used greyscale and virtual histology (VH) intravascular ultrasound (IVUS) to study the presence and characteristics of atherosclerotic plaque in the left anterior d...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Subclinical hypothyroidism (SCH) is a common disorder which has adverse cardiovascular effects. Epicardial adipose tissue (EAT), a novel marker of cardiovascular risk, is increased in SCH. AIM:We aimed to investigate whether L-thyroxine treatment can reverse the thickening of EAT in SCH. METHODS:Forty-four...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2016.0053
更新日期：2016-01-01 00:00:00
abstract：:Authors presented intravitally diagnosed and well echocardiographically supplied documentary evidence for a huge thrombus positioned in the left atrioventricular ostium in a 52 years old woman within two months of Björk-Shiley mitral valve replacement because of a mitral valve disease. ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Primary percutaneous coronary intervention (PPCI) is regarded as the treatment of choice for ST elevation myocardial infarction (STEMI) patients. It has been emphasised that only experienced centres with round-the-clock cathlab facilities should perform PPCI. Some investigators have doubted whether PPCI perf...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND AND AIM:In this study, we aimed to evaluate myocardial functions in patients with diabetes mellitus (DM) and impaired glucose tolerance (IGT). We also aimed to investigate the relationship between B-type natriuretic peptide (BNP) levels and myocardial performance index (Tei index) in these patients. METHODS...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Arterial hypertension is one of the most common chronic diseases in the western world, affecting more than 25% of the adult population. AIM:The aim of this study was to assess changes in arterial blood pressure (BP) levels in hypertensive patients, after ablation of nerve terminals in renal arteries, using ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2017.0100
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Differences between men and women in the prevalence and clinical course of coronary artery disease (CAD) have been well documented. There are no data in literature on the differences between males and females in the incidence of post-infarction left ventricular (LV) wall motion abnormalities of akinesia/dysk...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Although increased left atrial size (LA) has been long regarded as one of the factors negatively influencing the long-term maintenance of sinus rhythm (SR) following cardioversion (CV) of atrial fibrillation (AF), some reports suggested that CV might be effective also in patients with large LA.Aim. We sought...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Patients hospitalized due to heart failure (HF) exacerbation tend to have a poor prognosis. Most previous studies were performed in large clinical centers and detailed analyses of HF patients hospitalized in district general hospitals are lacking. AIMS:The aim of this study was to assess the outcomes of pat...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15763
更新日期：2021-01-19 00:00:00
abstract：:A case of recurrent severe mitral regurgitation following blunt chest trauma with deceleration injury in a 61-year-old woman is presented. The patient had undergone previous CABG and mitral annuloplasty with the use of a flexible (Duran) ring. At reoperation, partial dehiscence of the annuloplasty ring, which had beco...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND AND AIM:The purpose of this study was to determine the role of dominant frequency (DF) and organised index (OI) in outcomes of pulmonary vein (PV) isolation for paroxysmal atrial fibrillation (AF). METHODS:OI and DF of electrograms in coronary vein (CS) during AF were obtained by frequency spectra analysis ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
