Abstract：
BACKGROUND:Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response. AIM:To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity. METHODS:In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later. RESULTS:Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9+/-26.6 to 94.5+/-20.8 mg/dl, p<0.005) in the atorvastatin group and by 9% in the diet alone group. Atorvastatin lowered plasma CRP from 5.16+/-1.9 to 2.88+/-1.06 mg/L (p<0.001) and MMP-9 activity from 64.3+/-28.1 to 35.4+/-20.0 ng/ml (p<0.0001). Atorvastatin-induced reductions in CRP and MMP-9 were greater than in the diet alone group. MMP-9 levels did not show significant changes in Group 2 after two months of diet. CONCLUSIONS:Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Ercan E,Tengiz I,Altuglu I,Sekuri C,Aliyev E,Ercan HE,Akin Msubject
Has Abstractpub_date
2004-05-01 00:00:00pages
454-8issue
5eissn
0022-9032issn
1897-4279journal_volume
60pub_type
临床试验,杂志文章,随机对照试验abstract：:Impedance cardiography (ICG) enables the non-invasive, reproducible, beat-to-beat estimation of stroke volume (SV) changes, and the measurement of the absolute values of the ejection time (ET) and pre-ejection period (PEP), which allows the indirect evaluation of cardiac contractility. The miniaturised, Holter-type im...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-01 00:00:00
abstract：:Ischaemic heart disease especially after previous myocardial infarction can predispose to the life-threatening ventricular arrhythmias. Late potentials (LP) are confirmed parameters predicting patients prone to sudden cardiac death in ventricular arrhythmias mechanism. Late potentials registered noninvasively from the...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A case of a 42-year old man with aortic valve endocarditis with peri-anular multi-chamber abscess formation and fistulous communication between right sinus of Valsalva and right ventricle, is presented. Transthoracic echocardiography revealed abnormal flow through the fistula confirmed at surgery. Intraoperatively the...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Although increased left atrial size (LA) has been long regarded as one of the factors negatively influencing the long-term maintenance of sinus rhythm (SR) following cardioversion (CV) of atrial fibrillation (AF), some reports suggested that CV might be effective also in patients with large LA.Aim. We sought...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：:The local coronary flow in 42 patients (mean age: 59 +/- 9 years) with ischemic heart disease was assessed by means of an 0.018" intracoronary Doppler guidewire. Study population was divided into two groups: group I--"normal vessels" (diameter stenosis < 30%) and group II--"stenosis vessels" (diameter stenosis > 60%)....
journal_title：Kardiologia polska
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
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更新日期：2020-12-23 00:00:00
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journal_title：Kardiologia polska
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2003-04-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15102
更新日期：2020-01-24 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.5603/KP.a2014.0166
更新日期：2015-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2019.0041
更新日期：2018-12-20 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:In patients with chronic stable coronary artery disease (CAD), well‑developed coronary collateral circulation (CCC) is known to reduce long‑term mortality. AIMS:The objective of this study was to determine the relationship of serum calprotectin (S100A8 / S100A9), angiopoietin‑1 (Ang‑1) and angiopoietin‑2 (A...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15023
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pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
doi：10.5603/KP.a2015.0177
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章,meta分析
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更新日期：2018-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
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pub_type： 杂志文章
doi：10.5603/KP.a2013.0316
更新日期：2014-01-01 00:00:00
abstract：:The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scienti...
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pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
