Abstract：
BACKGROUND:Lipid lowering therapy with statins is beneficial because of improvement in lipoprotein concentrations and additional pleiotropic effects. However, less is known about the pleotropic effect of fibrates. AIM:To investigate the effects of fenofibrate therapy on inflammatory markers and serum paraoxonase activity in patients with combined hyperlipidemia in addition to their lipid lowering effects. METHODS:Fifty patients (18 women, 32 men, mean age 50+/-8.7 years) with a history of combined hyperlipidemia and coronary artery disease were enrolled into the study. Serum lipids, inflammatory markers (high sensitivity C-reactive protein (hs-CRP) and fibrinogen levels) and paraoxonase levels were determined before and after two months of 250 mg per day of fenofibrate treatment. RESULTS:Fenofibrate decreased plasma fibrinogen level by 41% (from 3.9+/-0.9 mg/dl to 2.3+/-0.48 mg/dl, p<0.0001) and hs-CRP level by 71% (from 1.28 mg/dl to 0.36 mg/dl; p<0.0001). Changes in hs-CRP levels were not correlated with the changes in lipid levels. Compared with baseline, serum paraoxonase level was significantly increased after fenofibrate treatment (from 200+/-77U/L to 232+/-82U/L; p<0.001). We found a significant correlation between changes in HDL cholesterol and paraoxonase activity after two months of treatment (r=0.46, p=0.018). CONCLUSION:This study demonstrates that beyond improving lipids and lipoprotein levels, fenofibrate treatment increases paraoxonase activity and decreases inflammatory markers in patients with combined hyperlipidemia.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Yesilbursa D,Serdar A,Saltan Y,Serdar Z,Heper Y,Guclu S,Cordan Jsubject
Has Abstractpub_date
2005-06-01 00:00:00pages
526-30issue
6eissn
0022-9032issn
1897-4279journal_volume
62pub_type
杂志文章abstract：BACKGROUND:Bisoprolol is one of the most widely used beta-blockers characterised by cardioselectivity, and it has no intrinsic sympathomimetic activity. It is commonly used in the treatment of coronary heart disease and heart failure. AIM:The aim of study was to assess the bioequivalence of the film-coated tablets con...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2016.0106
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Severe cardiovascular complications are among the most important causes of mortality in systemic lupus erythematosus (SLE) patients. AIM:To assess the usefulness of echocardiography, ECG, and coronary artery calcium scoring (CACS) in the detection of myocardial ischaemia in SLE patients compared to single p...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND AND AIM:Patency of infarct-related artery (IRA) before percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is associated with better outcomes. Little is known of the clinical or angiographic predictors of IRA recanalisation after administration of combined fibrinolytic the...
journal_title：Kardiologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Tako-tsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is a temporary left ventricular dysfunction characterised by acute retrosternal rest pain, ST - segment elevation, slight elevation of cardiac necrosis markers, preferential apical akinesia or hypokinesia with basal hypercontractility in echocardi...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Low-density lipoprotein cholesterol (LDL-C) is the independent risk factor for coronary artery disease. Diabetes mellitus (DM) is associated with poor outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary interventions (PCI). The relationship between L...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:Slow ventricular tachycardia (VT), which is below the detection rate of implantable cardioverter-defibrillator may cause haemodynamical instability, when pharmacological agents or antitachycardia pacing are unsuccessful, electrical cardioversion is necessary. We present another method of termination of slow VT by ICD,...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:The chain of survival is a set of most important factors affecting survival after an out-of-hospital cardiac arrest (OHCA). Recognising the difficulties in applying the chain is the key to improving outcomes. Early return of spontaneous circulation (ROSC) after a cardiac arrest is a fundamental factor for pa...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2016.0001
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Sotalol is a class III antiarrhythmic drug commonly used in various arrhythmia treatments. However, due to its potent potassium channel inhibition, it can prolong the QT interval and lead to malignant arrhythmias. Empagliflozin is an inhibitor of sodium‑glucose cotransporter 2 (SGLT2) and has a positive effe...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15666
更新日期：2021-01-25 00:00:00
abstract：:Endothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been proposed that the vasoconstrictor effects of endothelin are produced at the local vascular level, the current study was performed to test the hypothesis that plasma endothelin concentrations are elevated in p...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND AND AIM:The aim of this study is to evaluate the effect of epicardial adipose tissue (EAT) thickness on left ventricular diastolic functions in patients with normal coronary arteries (NCA) proven by angiography. METHODS:We selected study patients who were referred to coronary angiography due to typical ches...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2016.0139
更新日期：2017-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:Different types of disorders, varying in time, concerning atrio-ventricular (AV) conductivity may occur during myocardial infarction (MI). Similarly, angiography may reveal the dynamics within lesions of thrombosis in arteries. A case of 58 year-old man, who suffered from temporal AV block of all degrees, and what is ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia. Percutaneous left atrial appendage occlusion (LAAO) may be considered for stroke prophylaxis in patients with nonvalvular AF (NVAF), especially in contraindications for oral anticoagulants (OAC) or high risk of bleeding. The data a...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2017.0115
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Recent data from "real world" registries and some randomised trials concerning the safety and efficacy of drug-eluting stents (DES) in patients with acute ST-elevation myocardial infarction (STEMI) are equivocal. AIM:We sought to compare DES with bare-metal stents (BMS) in STEMI patients treated with primar...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-06-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:An imbalance between the activity of matrix metalloproteinases (MMPs), particularly gelatinases, and tissue inhibitors of metalloproteinases (TIMPs) is considered as one of the mechanisms leading to aortocoronary graft failure. AIM:We aimed to assess the variability in gelatinase expression in the walls of ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2019.0015
更新日期：2019-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2017.0021
更新日期：2017-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-01 00:00:00
abstract：:We report a case of a 19-year-old patient with double outlet right ventricle (RV) and recurrent giant RV outflow tract pseudoaneurysm, after multiple redo surgery. The patient underwent implantation of a 10 mm Amplatzer Septal Occluder to close the pseudoaneurysm. Postinterventional echocardiography revealed dislocati...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0264
更新日期：2013-01-01 00:00:00
abstract：:Lead-dependent infective endocarditis (LDIE) has emerged as a serious complication of electrotherapy in the era of advanced medical technology and is a growing problem due to greater patient longevity, limited electrode life-time, an increasing number of abandoned leads, and subclinical symptoms. We present a case of ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Atherothrombotic diseases (ATEs) and venous thromboembolism (VTE) have been traditionally considered to have a distinct pathogenesis. Today, a growing body of evidence on the pathophysiology of thrombus formation has convincingly proved that they share more mutual risk factors than previously recognized. It has been s...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：10.33963/KP.14804
更新日期：2019-04-18 00:00:00
abstract：:Between 1st January and 31st December 1987 126 consecutive patients underwent full myocardial revascularization using at least one internal mammary artery bypass grafting in Department of Cardiovascular Surgery of University of Freiburg. In 78 patients (75 males, 3 females) DSA was performed within 8 days after surger...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, as well as the density of nuclei of myocytes. The values of all histometric parameters correlated well with the LV weight up to 350 g. In heavier hearts thes...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Atherosclerosis of coronary and peripheral arteries occurs rarely in premenopausal women. It has been postulated that sex hormones protect the vascular wall. AIM:To evaluate whether ultrasound assessment of the changes in the wall of carotid arteries provides any useful information on the severity of athero...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Aborted myocardial infarction (abMI) is a type of acute coronary syndrome in which patients treated with reperfusion avoid the great burden of necrosis. Yet, no definition of abMI in patients undergoing primary percutaneous coronary intervention (pPCI) has been proposed so far. AIMS:This study aimed to iden...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15650
更新日期：2021-01-25 00:00:00
abstract：BACKGROUND:There are numerous data indicating a significant role of the sympathoadrenal system and the reninangiotensin- aldosterone system in the regulation of blood pressure and the pathogenesis of essential hypertension. However, the genetic background of essential hypertension remains unclear. AIM:To determine the...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:In this review authors describe the mechanisms and possibilities of attenuation of ischaemia reperfusion injury in the myocardium. They describe modified reperfusion (postconditioning) and discuss its use in basic and clinical research. The proposed effects of modified reperfusion on the reperfusion injury were also d...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-10-01 00:00:00
