Abstract：
BACKGROUND:An imbalance between the activity of matrix metalloproteinases (MMPs), particularly gelatinases, and tissue inhibitors of metalloproteinases (TIMPs) is considered as one of the mechanisms leading to aortocoronary graft failure. AIM:We aimed to assess the variability in gelatinase expression in the walls of aortocoronary conduits and to evaluate its impact on coronary artery bypass grafting (CABG) outcomes. METHODS:The study included 101 consecutive patients (61 men and 40 women) who underwent CABG. An immunohisto-chemical analysis of MMP-2, MMP-9, TIMP-1, and TIMP-2 expression was performed on the cross-sections of the internal thoracic artery (ITA), radial artery (RA), and saphenous vein (SV). The histological findings were compared between patients with SV graft disease (SVGD[+] group) and those without occlusions in the SV (SVGD[-] group). RESULTS:The median MMP and TIMP expression was the weakest in the ITA wall. MMP expression was comparable between the RA and SV cross-sections, whereas TIMP expression was stronger in the RA than in the SV wall (p < 0.05). In most SV segments, but not in the arteries, immunostaining intensity for MMP was comparable to or stronger than for TIMPs. In the veins harvested from the SVGD(+) group, MMP-2 and MMP-9 tissue expression was more pronounced than in the SVGD(-) group. TIMP levels were comparable between groups. CONCLUSIONS:Imbalance in the metalloproteinase-to-inhibitor tissue expression in the vessel wall might predispose to graft failure. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Perek B,Kowalska K,Nowicki M,Kempisty B,Puślecki M,Jankowski M,Jemielity M,Malińska Adoi
10.5603/KP.a2019.0015subject
Has Abstractpub_date
2019-01-01 00:00:00pages
217-224issue
2eissn
0022-9032issn
1897-4279pii
VM/OJS/KP/12935journal_volume
77pub_type
杂志文章abstract：BACKGROUND:Recent data from "real world" registries and some randomised trials concerning the safety and efficacy of drug-eluting stents (DES) in patients with acute ST-elevation myocardial infarction (STEMI) are equivocal. AIM:We sought to compare DES with bare-metal stents (BMS) in STEMI patients treated with primar...
journal_title：Kardiologia polska
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更新日期：2013-01-01 00:00:00
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journal_title：Kardiologia polska
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更新日期：2003-01-01 00:00:00
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journal_title：Kardiologia polska
pub_type： 杂志文章,meta分析,评审
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journal_title：Kardiologia polska
pub_type： 杂志文章
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journal_title：Kardiologia polska
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doi：
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journal_title：Kardiologia polska
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journal_title：Kardiologia polska
pub_type： 临床试验,杂志文章
doi：
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journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
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doi：
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doi：
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